Human Gene SYNJ2 (ENST00000640338.1) Description and Page Index
Description: Inositol 5-phosphatase which may be involved in distinct membrane trafficking and signal transduction pathways. May mediate the inhibitory effect of Rac1 on endocytosis. (from UniProt O15056) RefSeq Summary (NM_003898): The gene is a member of the inositol-polyphosphate 5-phosphatase family. The encoded protein interacts with the ras-related C3 botulinum toxin substrate 1, which causes translocation of the encoded protein to the plasma membrane where it inhibits clathrin-mediated endocytosis. Alternative splicing results in multiple transcript variants. [provided by RefSeq, May 2010]. Gencode Transcript: ENST00000640338.1 Gencode Gene: ENSG00000078269.15 Transcript (Including UTRs) Position: hg38 chr6:157,981,954-158,094,094 Size: 112,141 Total Exon Count: 27 Strand: + Coding Region Position: hg38 chr6:157,981,962-158,094,010 Size: 112,049 Coding Exon Count: 27
ID:SYNJ2_HUMAN DESCRIPTION: RecName: Full=Synaptojanin-2; EC=188.8.131.52; AltName: Full=Synaptic inositol 1,4,5-trisphosphate 5-phosphatase 2; FUNCTION: Inositol 5-phosphatase which may be involved in distinct membrane trafficking and signal transduction pathways. May mediate the inhibitory effect of Rac1 on endocytosis. CATALYTIC ACTIVITY: 1-phosphatidyl-1D-myo-inositol 4,5- bisphosphate + H(2)O = 1-phosphatidyl-1D-myo-inositol 4-phosphate + phosphate. SUBUNIT: Binds to GRB2. Isoform 2A binds to SYNJ2BP/OMP25. Isoform 2B2 C-terminal proline-rich region binds to a variety of SH3 domain-containing proteins including SH3GL1, SH3GL2, SH3GL3 and GRB2. INTERACTION: P62993:GRB2; NbExp=2; IntAct=EBI-310513, EBI-401755; P16333:NCK1; NbExp=3; IntAct=EBI-310513, EBI-389883; SUBCELLULAR LOCATION: Membrane (By similarity). Note=Predominantly associated with the particulate fractions (By similarity). SIMILARITY: Belongs to the synaptojanin family. SIMILARITY: In the central section; belongs to the inositol 1,4,5- trisphosphate 5-phosphatase family. SIMILARITY: Contains 1 RRM (RNA recognition motif) domain. SIMILARITY: Contains 1 SAC domain. SEQUENCE CAUTION: Sequence=AAH43277.1; Type=Erroneous initiation;
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on O15056
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.