Human Gene IQCH (ENST00000629425.2) Description and Page Index
  Description: Homo sapiens IQ motif containing H (IQCH), transcript variant 5, mRNA. (from RefSeq NM_001284349)
Gencode Transcript: ENST00000629425.2
Gencode Gene: ENSG00000103599.20
Transcript (Including UTRs)
   Position: hg38 chr15:67,254,848-67,374,168 Size: 119,321 Total Exon Count: 7 Strand: +
Coding Region
   Position: hg38 chr15:67,344,074-67,373,498 Size: 29,425 Coding Exon Count: 5 

Page IndexSequence and LinksUniProtKB CommentsCTDRNA-Seq ExpressionMicroarray Expression
RNA StructureProtein StructureOther SpeciesGO AnnotationsmRNA DescriptionsOther Names
Methods
Data last updated: 2019-09-04

-  Sequence and Links to Tools and Databases
 
Genomic Sequence (chr15:67,254,848-67,374,168)mRNA (may differ from genome)Protein (305 aa)
Gene SorterGenome BrowserOther Species FASTAGene interactionsTable SchemaBioGPS
CGAPEnsemblEntrez GeneExonPrimerGeneCardsHGNC
HPRDLynxMGIneXtProtOMIMPubMed
Stanford SOURCEUniProtKB

-  Comments and Description Text from UniProtKB
  ID: IQCH_HUMAN
DESCRIPTION: RecName: Full=IQ domain-containing protein H; AltName: Full=Testis development protein NYD-SP5;
FUNCTION: May play a regulatory role in spermatogenesis.
TISSUE SPECIFICITY: Expressed in fetal and adult testis, in germ cells but not somatic cells.
SIMILARITY: Contains 1 IQ domain.

-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene

-  RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
  Highest median expression: 4.03 RPKM in Testis
Total median expression: 13.04 RPKM



View in GTEx track of Genome Browser    View at GTEx portal     View GTEx Body Map

+  Microarray Expression Data
  Press "+" in the title bar above to open this section.

-  mRNA Secondary Structure of 3' and 5' UTRs
 
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -58.20234-0.249 Picture PostScript Text
3' UTR -155.80670-0.233 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  InterPro Domains: Graphical view of domain structure
IPR000048 - IQ_motif_EF-hand-BS

ModBase Predicted Comparative 3D Structure on Q86VS3
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The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
Genome BrowserGenome BrowserNo orthologNo orthologNo orthologNo ortholog
Gene Details     
Gene Sorter     
MGIRGD    
Protein SequenceProtein Sequence    
AlignmentAlignment    

-  Gene Ontology (GO) Annotations with Structured Vocabulary
  Molecular Function:
GO:0003674 molecular_function

Biological Process:
GO:0008150 biological_process

Cellular Component:
GO:0005575 cellular_component


-  Descriptions from all associated GenBank mRNAs
  AY014282 - Homo sapiens protein kinase NYD-SP5 mRNA, complete cds.
AK304303 - Homo sapiens cDNA FLJ57443 complete cds.
BC031041 - Homo sapiens IQ motif containing H, mRNA (cDNA clone IMAGE:5271948), complete cds.
AK292478 - Homo sapiens cDNA FLJ76950 complete cds, highly similar to Homo sapiens IQ motif containing H, transcript variant 1, mRNA.
BC048964 - Homo sapiens IQ motif containing H, mRNA (cDNA clone MGC:57142 IMAGE:5297681), complete cds.
BC039292 - Homo sapiens IQ motif containing H, mRNA (cDNA clone MGC:39471 IMAGE:5270043), complete cds.
AK022538 - Homo sapiens cDNA FLJ12476 fis, clone NT2RM1000978.
CU690588 - Synthetic construct Homo sapiens gateway clone IMAGE:100021065 5' read IQCH mRNA.
KJ899477 - Synthetic construct Homo sapiens clone ccsbBroadEn_08871 IQCH gene, encodes complete protein.
BC039463 - Homo sapiens IQ motif containing H, mRNA (cDNA clone IMAGE:5167355), with apparent retained intron.
JD519595 - Sequence 500619 from Patent EP1572962.
JD447827 - Sequence 428851 from Patent EP1572962.
JD202512 - Sequence 183536 from Patent EP1572962.
JD053132 - Sequence 34156 from Patent EP1572962.
JD177056 - Sequence 158080 from Patent EP1572962.
JD371553 - Sequence 352577 from Patent EP1572962.
JD509408 - Sequence 490432 from Patent EP1572962.
JD399351 - Sequence 380375 from Patent EP1572962.
KJ906304 - Synthetic construct Homo sapiens clone ccsbBroadEn_15974 IQCH gene, encodes complete protein.

-  Other Names for This Gene
  Alternate Gene Symbols: A8K8W3, C9JPR6, IQCH_HUMAN, NM_001284349, Q4G0S6, Q86VS3, Q8NEH9, Q9BWX2, Q9H9Y1, Q9UF88, uc002aqn.1, uc002aqn.2, uc002aqn.3
UCSC ID: uc002aqn.3
RefSeq Accession: NM_001284349
Protein: Q86VS3 (aka IQCH_HUMAN)
CCDS: CCDS76772.1

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.