Human Gene CDC16 (ENST00000628084.2) Description and Page Index
  Description: cell division cycle 16 (from HGNC CDC16)
RefSeq Summary (NM_003903): The protein encoded by this gene functions as a protein ubiquitin ligase and is a component of the multiprotein APC complex. The APC complex is a cyclin degradation system that governs exit from mitosis by targeting cell cycle proteins for degredation by the 26S proteasome. Each component protein of the APC complex is highly conserved among eukaryotic organisms. This protein, and other APC complex proteins, contain a tetratricopeptide repeat (TPR) domain; a protein domain that is often involved in protein-protein interactions and the assembly of multiprotein complexes. Multiple alternatively spliced transcript variants, encoding distinct proteins, have been identified. [provided by RefSeq, Jan 2016].
Gencode Transcript: ENST00000628084.2
Gencode Gene: ENSG00000130177.16
Transcript (Including UTRs)
   Position: hg38 chr13:114,234,887-114,272,675 Size: 37,789 Total Exon Count: 18 Strand: +
Coding Region
   Position: hg38 chr13:114,239,392-114,272,443 Size: 33,052 Coding Exon Count: 13 

Page IndexSequence and LinksCTDRNA-Seq ExpressionMicroarray ExpressionRNA Structure
Protein StructureOther SpeciesmRNA DescriptionsPathwaysOther NamesMethods
Data last updated: 2019-09-04

-  Sequence and Links to Tools and Databases
Genomic Sequence (chr13:114,234,887-114,272,675)mRNA (may differ from genome)Protein (475 aa)
Gene SorterGenome BrowserOther Species FASTAGene interactionsTable SchemaBioGPS
MGImyGene2PubMedStanford SOURCEUniProtKBWikipedia

-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene           more ... click here to view the complete list

-  RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
  Highest median expression: 30.29 RPKM in Testis
Total median expression: 1057.21 RPKM

View in GTEx track of Genome Browser    View at GTEx portal     View GTEx Body Map

+  Microarray Expression Data
  Press "+" in the title bar above to open this section.

-  mRNA Secondary Structure of 3' and 5' UTRs
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -198.10480-0.413 Picture PostScript Text
3' UTR -35.40150-0.236 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  InterPro Domains: Graphical view of domain structure
IPR013026 - TPR-contain_dom
IPR011990 - TPR-like_helical
IPR019734 - TPR_repeat

Pfam Domains:
PF13181 - Tetratricopeptide repeat

ModBase Predicted Comparative 3D Structure on Q5T8C6
The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
Genome BrowserGenome BrowserNo orthologNo orthologNo orthologNo ortholog
Gene Details     
Gene Sorter     
Protein SequenceProtein Sequence    

-  Descriptions from all associated GenBank mRNAs
  AK296424 - Homo sapiens cDNA FLJ56731 complete cds, highly similar to Cell division cycle protein 16 homolog.
BC017244 - Homo sapiens cell division cycle 16 homolog (S. cerevisiae), mRNA (cDNA clone MGC:29445 IMAGE:4877392), complete cds.
BC010875 - Homo sapiens cell division cycle 16 homolog (S. cerevisiae), mRNA (cDNA clone MGC:9971 IMAGE:3879150), complete cds.
JD211271 - Sequence 192295 from Patent EP1572962.
JD100826 - Sequence 81850 from Patent EP1572962.
AK315302 - Homo sapiens cDNA, FLJ96326, highly similar to Homo sapiens CDC16 cell division cycle 16 homolog (S. cerevisiae) (CDC16), mRNA.
JD196411 - Sequence 177435 from Patent EP1572962.
U18291 - Human CDC16Hs mRNA, complete cds.
AB590520 - Synthetic construct DNA, clone: pFN21AE2030, Homo sapiens CDC16 gene for cell division cycle 16 homolog, without stop codon, in Flexi system.
AF164598 - Homo sapiens cell division control protein 16 (CDC16) mRNA, complete cds.
CU677877 - Synthetic construct Homo sapiens gateway clone IMAGE:100023415 5' read CDC16 mRNA.
KJ897929 - Synthetic construct Homo sapiens clone ccsbBroadEn_07323 CDC16 gene, encodes complete protein.
AB209850 - Homo sapiens mRNA for CDC16 homolog protein.
HQ257896 - Synthetic construct Homo sapiens clone IMAGE:100072205 Unknown protein gene, encodes complete protein.
KJ901922 - Synthetic construct Homo sapiens clone ccsbBroadEn_11316 CDC16 gene, encodes complete protein.
BC050575 - Homo sapiens cDNA clone IMAGE:5735063, **** WARNING: chimeric clone ****.
AK095082 - Homo sapiens cDNA FLJ37763 fis, clone BRHIP2024398, highly similar to Human CDC16Hs mRNA.
JD053853 - Sequence 34877 from Patent EP1572962.

-  Biochemical and Signaling Pathways
  KEGG - Kyoto Encyclopedia of Genes and Genomes
hsa04110 - Cell cycle
hsa04114 - Oocyte meiosis
hsa04120 - Ubiquitin mediated proteolysis
hsa04914 - Progesterone-mediated oocyte maturation

-  Other Names for This Gene
  Alternate Gene Symbols: BC017244, Q5T8C6, Q5T8C6_HUMAN, RP11-569D9.4-001, uc058yoz.1
UCSC ID: uc058yoz.1
RefSeq Accession: NM_003903
Protein: Q5T8C6

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.