Human Gene ZNF518A (ENST00000624776.3) Description and Page Index
  Description: Homo sapiens zinc finger protein 518A (ZNF518A), transcript variant 11, mRNA. (from RefSeq NM_001330738)
RefSeq Summary (NM_001278525): The protein encoded by this gene is a member of the krueppel C2H2-type zinc finger protein family. The encoded protein contains five zinc fingers and is likely a nuclear transcriptional regulator. Numerous transcript variants encoding two different isoforms have been found for this gene. [provided by RefSeq, Aug 2016]. Sequence Note: This RefSeq record was created from transcript and genomic sequence data to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments. ##Evidence-Data-START## Transcript exon combination :: BC030967.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1965299, SAMEA1966682 [ECO:0000348] ##Evidence-Data-END##
Gencode Transcript: ENST00000624776.3
Gencode Gene: ENSG00000177853.14
Transcript (Including UTRs)
   Position: hg38 chr10:96,130,056-96,163,752 Size: 33,697 Total Exon Count: 6 Strand: +
Coding Region
   Position: hg38 chr10:96,156,323-96,160,774 Size: 4,452 Coding Exon Count: 1 

Page IndexSequence and LinksUniProtKB CommentsCTDMicroarray ExpressionRNA Structure
Protein StructureOther SpeciesGO AnnotationsmRNA DescriptionsOther NamesMethods
Data last updated: 2019-09-04

-  Sequence and Links to Tools and Databases
 
Genomic Sequence (chr10:96,130,056-96,163,752)mRNA (may differ from genome)Protein (1483 aa)
Gene SorterGenome BrowserOther Species FASTAGene interactionsTable SchemaBioGPS
CGAPEnsemblEntrez GeneExonPrimerGeneCardsHGNC
HPRDLynxMGIneXtProtOMIMPubMed
Stanford SOURCEUniProtKB

-  Comments and Description Text from UniProtKB
  ID: Z518A_HUMAN
DESCRIPTION: RecName: Full=Zinc finger protein 518A;
FUNCTION: May be involved in transcriptional regulation.
SUBCELLULAR LOCATION: Nucleus (Probable).
SIMILARITY: Belongs to the krueppel C2H2-type zinc-finger protein family.
SIMILARITY: Contains 5 C2H2-type zinc fingers.
SEQUENCE CAUTION: Sequence=AAH30967.1; Type=Miscellaneous discrepancy; Note=Contaminating sequence. Potential poly-A sequence; Sequence=BAA20793.2; Type=Erroneous initiation;

-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene

+  Microarray Expression Data
  Press "+" in the title bar above to open this section.

-  mRNA Secondary Structure of 3' and 5' UTRs
 
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -132.70564-0.235 Picture PostScript Text
3' UTR -676.402978-0.227 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  InterPro Domains: Graphical view of domain structure
IPR007087 - Znf_C2H2
IPR015880 - Znf_C2H2-like
IPR013087 - Znf_C2H2/integrase_DNA-bd

ModBase Predicted Comparative 3D Structure on Q6AHZ1
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The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
Genome BrowserGenome BrowserNo orthologNo orthologNo orthologNo ortholog
Gene Details     
Gene Sorter     
MGIRGD    
Protein SequenceProtein Sequence    
AlignmentAlignment    

-  Gene Ontology (GO) Annotations with Structured Vocabulary
  Molecular Function:
GO:0000981 RNA polymerase II transcription factor activity, sequence-specific DNA binding
GO:0003676 nucleic acid binding
GO:0003677 DNA binding
GO:0046872 metal ion binding

Biological Process:
GO:0006351 transcription, DNA-templated
GO:0006355 regulation of transcription, DNA-templated
GO:0006357 regulation of transcription from RNA polymerase II promoter

Cellular Component:
GO:0005634 nucleus


-  Descriptions from all associated GenBank mRNAs
  LF211320 - JP 2014500723-A/18823: Polycomb-Associated Non-Coding RNAs.
MA446897 - JP 2018138019-A/18823: Polycomb-Associated Non-Coding RNAs.
CR627437 - Homo sapiens mRNA; cDNA DKFZp781O2147 (from clone DKFZp781O2147).
BC109045 - Homo sapiens zinc finger protein 518A, mRNA (cDNA clone MGC:125707 IMAGE:40028941), complete cds.
BC109046 - Homo sapiens zinc finger protein 518A, mRNA (cDNA clone MGC:125710 IMAGE:40028950), complete cds.
AK095317 - Homo sapiens cDNA FLJ37998 fis, clone CTONG2012001.
BC030967 - Homo sapiens zinc finger protein 518A, mRNA (cDNA clone IMAGE:4693182), partial cds.
LF345595 - JP 2014500723-A/153098: Polycomb-Associated Non-Coding RNAs.
MA581172 - JP 2018138019-A/153098: Polycomb-Associated Non-Coding RNAs.
AB002333 - Homo sapiens mRNA for KIAA0335 gene.
JD312907 - Sequence 293931 from Patent EP1572962.
JD362263 - Sequence 343287 from Patent EP1572962.
JD186351 - Sequence 167375 from Patent EP1572962.
JD254816 - Sequence 235840 from Patent EP1572962.
JD160565 - Sequence 141589 from Patent EP1572962.
JD280970 - Sequence 261994 from Patent EP1572962.
JD550760 - Sequence 531784 from Patent EP1572962.
JD565895 - Sequence 546919 from Patent EP1572962.
AB384462 - Synthetic construct DNA, clone: pF1KA0335, Homo sapiens ZNF518 gene for zinc finger protein 518, complete cds, without stop codon, in Flexi system.
LF345598 - JP 2014500723-A/153101: Polycomb-Associated Non-Coding RNAs.
MA581175 - JP 2018138019-A/153101: Polycomb-Associated Non-Coding RNAs.
LF345599 - JP 2014500723-A/153102: Polycomb-Associated Non-Coding RNAs.
MA581176 - JP 2018138019-A/153102: Polycomb-Associated Non-Coding RNAs.
LF345600 - JP 2014500723-A/153103: Polycomb-Associated Non-Coding RNAs.
MA581177 - JP 2018138019-A/153103: Polycomb-Associated Non-Coding RNAs.
LF345601 - JP 2014500723-A/153104: Polycomb-Associated Non-Coding RNAs.
MA581178 - JP 2018138019-A/153104: Polycomb-Associated Non-Coding RNAs.
KJ902030 - Synthetic construct Homo sapiens clone ccsbBroadEn_11424 ZNF518A gene, encodes complete protein.
LF345602 - JP 2014500723-A/153105: Polycomb-Associated Non-Coding RNAs.
MA581179 - JP 2018138019-A/153105: Polycomb-Associated Non-Coding RNAs.
LF345603 - JP 2014500723-A/153106: Polycomb-Associated Non-Coding RNAs.
MA581180 - JP 2018138019-A/153106: Polycomb-Associated Non-Coding RNAs.
JD482131 - Sequence 463155 from Patent EP1572962.
LF345604 - JP 2014500723-A/153107: Polycomb-Associated Non-Coding RNAs.
MA581181 - JP 2018138019-A/153107: Polycomb-Associated Non-Coding RNAs.
JD245615 - Sequence 226639 from Patent EP1572962.
JD047317 - Sequence 28341 from Patent EP1572962.
JD420519 - Sequence 401543 from Patent EP1572962.
JD359864 - Sequence 340888 from Patent EP1572962.
JD196748 - Sequence 177772 from Patent EP1572962.
LF345605 - JP 2014500723-A/153108: Polycomb-Associated Non-Coding RNAs.
MA581182 - JP 2018138019-A/153108: Polycomb-Associated Non-Coding RNAs.
JD538772 - Sequence 519796 from Patent EP1572962.
JD434643 - Sequence 415667 from Patent EP1572962.
JD303347 - Sequence 284371 from Patent EP1572962.
JD327472 - Sequence 308496 from Patent EP1572962.
JD313984 - Sequence 295008 from Patent EP1572962.
JD479381 - Sequence 460405 from Patent EP1572962.
JD120016 - Sequence 101040 from Patent EP1572962.
JD521654 - Sequence 502678 from Patent EP1572962.
JD214333 - Sequence 195357 from Patent EP1572962.
JD495677 - Sequence 476701 from Patent EP1572962.
JD284094 - Sequence 265118 from Patent EP1572962.
LF345606 - JP 2014500723-A/153109: Polycomb-Associated Non-Coding RNAs.
MA581183 - JP 2018138019-A/153109: Polycomb-Associated Non-Coding RNAs.
JD449227 - Sequence 430251 from Patent EP1572962.
JD067948 - Sequence 48972 from Patent EP1572962.
JD368487 - Sequence 349511 from Patent EP1572962.
JD419916 - Sequence 400940 from Patent EP1572962.
JD052144 - Sequence 33168 from Patent EP1572962.
JD363018 - Sequence 344042 from Patent EP1572962.
JD359471 - Sequence 340495 from Patent EP1572962.
JD175550 - Sequence 156574 from Patent EP1572962.
JD456333 - Sequence 437357 from Patent EP1572962.
JD149120 - Sequence 130144 from Patent EP1572962.

-  Other Names for This Gene
  Alternate Gene Symbols: A0PJI5, KIAA0335, NM_001330738, O15044, Q32MP4, Q6AHZ1, uc031wpn.1, uc031wpn.2, Z518A_HUMAN, ZNF518
UCSC ID: uc031wpn.2
RefSeq Accession: NM_001278525
Protein: Q6AHZ1 (aka Z518A_HUMAN)
CCDS: CCDS73170.1

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.