Human Gene CYP2C8 (ENST00000623108.3) Description and Page Index
  Description: Homo sapiens cytochrome P450 family 2 subfamily C member 8 (CYP2C8), transcript variant 2, mRNA. (from RefSeq NM_001198853)
RefSeq Summary (NM_001198853): This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This protein localizes to the endoplasmic reticulum and its expression is induced by phenobarbital. The enzyme is known to metabolize many xenobiotics, including the anticonvulsive drug mephenytoin, benzo(a)pyrene, 7-ethyoxycoumarin, and the anti-cancer drug taxol. This gene is located within a cluster of cytochrome P450 genes on chromosome 10q24. Several transcript variants encoding a few different isoforms have been found for this gene. [provided by RefSeq, Nov 2010].
Gencode Transcript: ENST00000623108.3
Gencode Gene: ENSG00000138115.14
Transcript (Including UTRs)
   Position: hg38 chr10:95,036,772-95,069,497 Size: 32,726 Total Exon Count: 9 Strand: -
Coding Region
   Position: hg38 chr10:95,037,128-95,067,649 Size: 30,522 Coding Exon Count: 8 

Page IndexSequence and LinksUniProtKB CommentsMalaCardsCTDRNA-Seq Expression
Microarray ExpressionRNA StructureProtein StructureOther SpeciesGO AnnotationsmRNA Descriptions
PathwaysOther NamesMethods
Data last updated: 2019-09-04

-  Sequence and Links to Tools and Databases
Genomic Sequence (chr10:95,036,772-95,069,497)mRNA (may differ from genome)Protein (420 aa)
Gene SorterGenome BrowserOther Species FASTAGene interactionsTable SchemaBioGPS
CGAPEnsemblEntrez GeneExonPrimerGeneCardsHGNC

-  Comments and Description Text from UniProtKB
DESCRIPTION: SubName: Full=cDNA FLJ59467, highly similar to Cytochrome P450 2C8 (EC;
SIMILARITY: Belongs to the cytochrome P450 family.

-  MalaCards Disease Associations
  MalaCards Gene Search: CYP2C8
Diseases sorted by gene-association score: cyp2c8-related altered drug metabolism* (500), osteonecrosis of the jaw (18), osteonecrosis (6)
* = Manually curated disease association

-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene           more ... click here to view the complete list

-  RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
  Highest median expression: 430.31 RPKM in Liver
Total median expression: 482.41 RPKM

View in GTEx track of Genome Browser    View at GTEx portal     View GTEx Body Map

+  Microarray Expression Data
  Press "+" in the title bar above to open this section.

-  mRNA Secondary Structure of 3' and 5' UTRs
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -83.80343-0.244 Picture PostScript Text
3' UTR -60.40356-0.170 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  InterPro Domains: Graphical view of domain structure
IPR001128 - Cyt_P450
IPR017972 - Cyt_P450_CS
IPR002401 - Cyt_P450_E_grp-I

Pfam Domains:
PF00067 - Cytochrome P450

ModBase Predicted Comparative 3D Structure on B7Z1F5
The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
No orthologNo orthologNo orthologNo orthologNo orthologNo ortholog

-  Gene Ontology (GO) Annotations with Structured Vocabulary
  Molecular Function:
GO:0004497 monooxygenase activity
GO:0005506 iron ion binding
GO:0016491 oxidoreductase activity
GO:0016705 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen
GO:0020037 heme binding
GO:0046872 metal ion binding

Biological Process:
GO:0055114 oxidation-reduction process

-  Descriptions from all associated GenBank mRNAs
  M21941 - Human cytochrome P-450 S-mephenytoin 4-hydroxylase (P-450mp) mRNA, 3' end, clone MP-20.
M17397 - Human cytochrome P-450 1 functional form mRNA, complete cds.
M17398 - Human cytochrome P-450 1 mRNA, complete cds, clone Hp1-2.
AK293327 - Homo sapiens cDNA FLJ59467 complete cds, highly similar to Cytochrome P450 2C8 (EC
X51535 - Homo sapiens mRNA for cytochrome P-450 HPH.
Y00498 - H. sapiens mRNA for IIC2.
M21942 - Human cytochrome P-450 S-mephenytoin 4-hydroxylase (P-450mp) mRNA, 3' end, clone MP-12.
BC020596 - Homo sapiens cytochrome P450, family 2, subfamily C, polypeptide 8, mRNA (cDNA clone MGC:22146 IMAGE:4767198), complete cds.
AK303813 - Homo sapiens cDNA FLJ56839 complete cds, highly similar to Cytochrome P450 2C8 (EC
AK292753 - Homo sapiens cDNA FLJ75368 complete cds, highly similar to Homo sapiens cytochrome P450, family 2, subfamily C, polypeptide 8, transcript variant Hp1-1, mRNA.
JD515503 - Sequence 496527 from Patent EP1572962.
JD205196 - Sequence 186220 from Patent EP1572962.
AK315823 - Homo sapiens cDNA, FLJ79472 complete cds, highly similar to Cytochrome P450 2C8 (EC
AK293328 - Homo sapiens cDNA FLJ59468 complete cds, highly similar to Cytochrome P450 2C8 (EC
JD335574 - Sequence 316598 from Patent EP1572962.
JD086173 - Sequence 67197 from Patent EP1572962.
E10639 - Human cDNA encoding cytochrome P4502C8.
E10862 - cDNA encoding human cytochrome P450.
E10863 - cDNA encoding human cytochrome P450.
E10864 - cDNA encoding human cytochrome P450.
DQ891400 - Synthetic construct clone IMAGE:100004030; FLH176591.01X; RZPDo839F01122D cytochrome P450, family 2, subfamily C, polypeptide 8 (CYP2C8) gene, encodes complete protein.
DQ894579 - Synthetic construct Homo sapiens clone IMAGE:100009039; FLH176587.01L; RZPDo839F01121D cytochrome P450, family 2, subfamily C, polypeptide 8 (CYP2C8) gene, encodes complete protein.
JD053467 - Sequence 34491 from Patent EP1572962.
JD156499 - Sequence 137523 from Patent EP1572962.
JD535710 - Sequence 516734 from Patent EP1572962.
AK298401 - Homo sapiens cDNA FLJ56820 complete cds, highly similar to Cytochrome P450 2C8 (EC
JD343531 - Sequence 324555 from Patent EP1572962.

-  Biochemical and Signaling Pathways
  KEGG - Kyoto Encyclopedia of Genes and Genomes
hsa00590 - Arachidonic acid metabolism
hsa00591 - Linoleic acid metabolism
hsa00830 - Retinol metabolism
hsa00980 - Metabolism of xenobiotics by cytochrome P450
hsa00982 - Drug metabolism - cytochrome P450
hsa01100 - Metabolic pathways

-  Other Names for This Gene
  Alternate Gene Symbols: B7Z1F5, B7Z1F5_HUMAN, NM_001198853, uc010qoa.1, uc010qoa.2
UCSC ID: uc010qoa.2
RefSeq Accession: NM_001198853
Protein: B7Z1F5 CCDS: CCDS73166.1

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.