ID:PAMR1_HUMAN DESCRIPTION: RecName: Full=Inactive serine protease PAMR1; AltName: Full=Peptidase domain-containing protein associated with muscle regeneration 1; AltName: Full=Regeneration-associated muscle protease homolog; Flags: Precursor; FUNCTION: May play a role in regeneration of skeletal muscle (By similarity). SUBCELLULAR LOCATION: Secreted (Potential). INDUCTION: Strongly down-regulated in muscle cell lines derived from biopsies of 5 Duchenne muscular dystrophy (DMD) patients compared to a normal muscle cell line. SIMILARITY: Belongs to the peptidase S1 family. SIMILARITY: Contains 1 CUB domain. SIMILARITY: Contains 1 EGF-like domain. SIMILARITY: Contains 1 peptidase S1 domain. SIMILARITY: Contains 2 Sushi (CCP/SCR) domains. CAUTION: Although related to peptidase S1 family, lacks the conserved active Ser residue in position 665 which is replaced by a Thr, suggesting that it has no protease activity. SEQUENCE CAUTION: Sequence=AAQ15224.1; Type=Frameshift; Positions=334;
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on Q6UXH9
The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.
Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.