Human Gene CCNA2 (ENST00000618014.1) Description and Page Index
Description: Essential for the control of the cell cycle at the G1/S (start) and the G2/M (mitosis) transitions. (from UniProt P20248) RefSeq Summary (NM_001237): The protein encoded by this gene belongs to the highly conserved cyclin family, whose members function as regulators of the cell cycle. This protein binds and activates cyclin-dependent kinase 2 and thus promotes transition through G1/S and G2/M. [provided by RefSeq, Aug 2016]. Sequence Note: This RefSeq record was created from transcript and genomic sequence data to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: SRR1163657.111004.1, SRR1163658.202233.1 [ECO:0000332] RNAseq introns :: mixed/partial sample support SAMEA1965299, SAMEA1966682 [ECO:0000350] ##Evidence-Data-END## ##RefSeq-Attributes-START## MANE Ensembl match :: ENST00000274026.10/ ENSP00000274026.5 RefSeq Select criteria :: based on single protein-coding transcript ##RefSeq-Attributes-END## Gencode Transcript: ENST00000618014.1 Gencode Gene: ENSG00000145386.10 Transcript (Including UTRs) Position: hg38 chr4:121,816,445-121,823,933 Size: 7,489 Total Exon Count: 8 Strand: - Coding Region Position: hg38 chr4:121,817,638-121,823,628 Size: 5,991 Coding Exon Count: 8
ID:CCNA2_HUMAN DESCRIPTION: RecName: Full=Cyclin-A2; Short=Cyclin-A; FUNCTION: Essential for the control of the cell cycle at the G1/S (start) and the G2/M (mitosis) transitions. SUBUNIT: Interacts with the CDK1 and CDK2 protein kinases to form a serine/threonine kinase holoenzyme complex. The cyclin subunit imparts substrate specificity to the complex. When associated with CDK2 (but not with CDK1), interacts with SCAPER. INTERACTION: P24941:CDK2; NbExp=16; IntAct=EBI-457097, EBI-375096; P38936:CDKN1A; NbExp=2; IntAct=EBI-457097, EBI-375077; P46527:CDKN1B; NbExp=12; IntAct=EBI-457097, EBI-519280; Q96PU4:UHRF2; NbExp=2; IntAct=EBI-457097, EBI-625304; SUBCELLULAR LOCATION: Nucleus. Cytoplasm. Note=Cytoplasmic when associated with SCAPER. DEVELOPMENTAL STAGE: Accumulates steadily during G2 and is abruptly destroyed at mitosis. PTM: Polyubiquitinated via 'Lys-11'-linked ubiquitin by the anaphase-promoting complex (APC/C), leading to its degradation by the proteasome. Deubiquitinated and stabilized by USP37 enables entry into S phase (By similarity). SIMILARITY: Belongs to the cyclin family. Cyclin AB subfamily. WEB RESOURCE: Name=NIEHS-SNPs; URL="http://egp.gs.washington.edu/data/ccna2/";
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on P20248
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.