Human Gene UBE2V1 (ENST00000617119.4) Description and Page Index
  Description: Homo sapiens ubiquitin conjugating enzyme E2 V1 (UBE2V1), transcript variant 14, mRNA. (from RefSeq NM_001282576)
RefSeq Summary (NM_001282576): Ubiquitin-conjugating E2 enzyme variant proteins constitute a distinct subfamily within the E2 protein family. They have sequence similarity to other ubiquitin-conjugating enzymes but lack the conserved cysteine residue that is critical for the catalytic activity of E2s. The protein encoded by this gene is located in the nucleus and can cause transcriptional activation of the human FOS proto-oncogene. It is thought to be involved in the control of differentiation by altering cell cycle behavior. Alternatively spliced transcript variants encoding multiple isoforms have been described for this gene, and multiple pseudogenes of this gene have been identified. Co-transcription of this gene and the neighboring upstream gene generates a rare transcript (Kua-UEV), which encodes a fusion protein comprised of sequence sharing identity with each individual gene product. [provided by RefSeq, Apr 2012].
Gencode Transcript: ENST00000617119.4
Gencode Gene: ENSG00000244687.11
Transcript (Including UTRs)
   Position: hg38 chr20:50,081,124-50,113,198 Size: 32,075 Total Exon Count: 5 Strand: -
Coding Region
   Position: hg38 chr20:50,082,768-50,096,716 Size: 13,949 Coding Exon Count: 3 

Page IndexSequence and LinksCTDRNA-Seq ExpressionMicroarray ExpressionRNA Structure
Protein StructureOther SpeciesmRNA DescriptionsOther NamesMethods
Data last updated: 2019-09-04

-  Sequence and Links to Tools and Databases
Genomic Sequence (chr20:50,081,124-50,113,198)mRNA (may differ from genome)Protein (105 aa)
Gene SorterGenome BrowserOther Species FASTAGene interactionsTable SchemaBioGPS
CGAPEnsemblEntrez GeneExonPrimerGeneCardsHGNC

-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene           more ... click here to view the complete list

-  RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
  Highest median expression: 3.79 RPKM in Cells - EBV-transformed lymphocytes
Total median expression: 68.70 RPKM

View in GTEx track of Genome Browser    View at GTEx portal     View GTEx Body Map

+  Microarray Expression Data
  Press "+" in the title bar above to open this section.

-  mRNA Secondary Structure of 3' and 5' UTRs
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -160.50470-0.341 Picture PostScript Text
3' UTR -405.401644-0.247 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  InterPro Domains: Graphical view of domain structure
IPR019547 - KuaUb-conj-enz_UEV1
IPR000608 - UBQ-conjugat_E2
IPR016135 - UBQ-conjugating_enzyme/RWD

Pfam Domains:
PF10520 - B domain of TMEM189, localisation domain
PF00179 - Ubiquitin-conjugating enzyme

ModBase Predicted Comparative 3D Structure on G3V2F7
The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
Genome BrowserGenome BrowserNo orthologNo orthologNo orthologNo ortholog
Gene Details     
Gene Sorter     
Protein SequenceProtein Sequence    

-  Descriptions from all associated GenBank mRNAs
  U49278 - Homo sapiens UEV-1 (UBE2V) mRNA, partial cds.
BX647511 - Homo sapiens mRNA; cDNA DKFZp686I21199 (from clone DKFZp686I21199).
BX648147 - Homo sapiens mRNA; cDNA DKFZp686G1080 (from clone DKFZp686G1080).
U97279 - Homo sapiens UEV-1 (UBE2V) alternatively spliced incompletely processed mRNA, partial cds.
AL110132 - Homo sapiens mRNA; cDNA DKFZp564H192 (from clone DKFZp564H192).
JD557645 - Sequence 538669 from Patent EP1572962.
AF049671 - Homo sapiens clone CIR1 cell immortalization-related mRNA sequence.
U39360 - Homo sapiens DNA-binding protein (CROC-1A) mRNA, complete cds.
U39361 - Homo sapiens DNA-binding protein (CROC-1B) mRNA, complete cds.
BC008944 - Homo sapiens ubiquitin-conjugating enzyme E2 variant 1, mRNA (cDNA clone IMAGE:2960953), partial cds.
BC000468 - Homo sapiens ubiquitin-conjugating enzyme E2 variant 1, mRNA (cDNA clone MGC:8586 IMAGE:2961017), complete cds.
JD273306 - Sequence 254330 from Patent EP1572962.
JD101605 - Sequence 82629 from Patent EP1572962.
JD315254 - Sequence 296278 from Patent EP1572962.
JD558001 - Sequence 539025 from Patent EP1572962.
JD272684 - Sequence 253708 from Patent EP1572962.
JD299451 - Sequence 280475 from Patent EP1572962.
DQ598317 - Homo sapiens piRNA piR-36383, complete sequence.
JD269185 - Sequence 250209 from Patent EP1572962.
JD133135 - Sequence 114159 from Patent EP1572962.
JD104747 - Sequence 85771 from Patent EP1572962.
JD192643 - Sequence 173667 from Patent EP1572962.
JD247296 - Sequence 228320 from Patent EP1572962.
JD413564 - Sequence 394588 from Patent EP1572962.
JD324264 - Sequence 305288 from Patent EP1572962.
JD240731 - Sequence 221755 from Patent EP1572962.
JD083928 - Sequence 64952 from Patent EP1572962.
JD110278 - Sequence 91302 from Patent EP1572962.
JD202857 - Sequence 183881 from Patent EP1572962.
JD377384 - Sequence 358408 from Patent EP1572962.
JD320567 - Sequence 301591 from Patent EP1572962.
JD391827 - Sequence 372851 from Patent EP1572962.
JD433549 - Sequence 414573 from Patent EP1572962.
JD272706 - Sequence 253730 from Patent EP1572962.
JD403675 - Sequence 384699 from Patent EP1572962.
JD253152 - Sequence 234176 from Patent EP1572962.
JD297643 - Sequence 278667 from Patent EP1572962.
JD218720 - Sequence 199744 from Patent EP1572962.
JD054937 - Sequence 35961 from Patent EP1572962.
JD498860 - Sequence 479884 from Patent EP1572962.
JD498861 - Sequence 479885 from Patent EP1572962.
JD241200 - Sequence 222224 from Patent EP1572962.
JD460143 - Sequence 441167 from Patent EP1572962.
JD261094 - Sequence 242118 from Patent EP1572962.
JD228794 - Sequence 209818 from Patent EP1572962.
JD488233 - Sequence 469257 from Patent EP1572962.
JD268228 - Sequence 249252 from Patent EP1572962.
JD061124 - Sequence 42148 from Patent EP1572962.
BC005215 - Homo sapiens cDNA clone IMAGE:3996506.
U97280 - Homo sapiens UEV1Bs (UBE2V) mRNA, alternatively spliced, partial cds.
AY008273 - Homo sapiens TRAF6-regulated IKK activator 1 beta Uev1A mRNA, complete cds.
U97281 - Homo sapiens UEV1As (UBE2V) mRNA, alternatively spliced, complete cds.
AK314754 - Homo sapiens cDNA, FLJ95620.
BT007382 - Homo sapiens ubiquitin-conjugating enzyme E2 variant 1 mRNA, complete cds.
CU674232 - Synthetic construct Homo sapiens gateway clone IMAGE:100017928 5' read UBE2V1 mRNA.
HQ448675 - Synthetic construct Homo sapiens clone IMAGE:100072117; CCSB004673_01 ubiquitin-conjugating enzyme E2 variant 1 (UBE2V1) gene, encodes complete protein.
KJ892347 - Synthetic construct Homo sapiens clone ccsbBroadEn_01741 UBE2V1 gene, encodes complete protein.
BC172339 - Synthetic construct Homo sapiens clone IMAGE:100069033, MGC:199044 TMEM189-UBE2V1 readthrough transcript (TMEM189-UBE2V1) mRNA, encodes complete protein.
AB587452 - Synthetic construct DNA, clone: pF1KB7917, Homo sapiens TMEM189-UBE2V1 gene for TMEM189-UBE2V1 readthrough, without stop codon, in Flexi system.

-  Other Names for This Gene
  Alternate Gene Symbols: G3V2F7, G3V2F7_HUMAN, hCG_2044781, NM_001282576, TMEM189, TMEM189-UBE2V1, uc031rue.1
UCSC ID: uc031rue.1
RefSeq Accession: NM_001282576
Protein: G3V2F7 CCDS: CCDS74740.1

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.