Human Gene UBE2V1 (ENST00000617119.4) Description and Page Index
Description: Homo sapiens ubiquitin conjugating enzyme E2 V1 (UBE2V1), transcript variant 14, mRNA. (from RefSeq NM_001282576) RefSeq Summary (NM_001282576): Ubiquitin-conjugating E2 enzyme variant proteins constitute a distinct subfamily within the E2 protein family. They have sequence similarity to other ubiquitin-conjugating enzymes but lack the conserved cysteine residue that is critical for the catalytic activity of E2s. The protein encoded by this gene is located in the nucleus and can cause transcriptional activation of the human FOS proto-oncogene. It is thought to be involved in the control of differentiation by altering cell cycle behavior. Alternatively spliced transcript variants encoding multiple isoforms have been described for this gene, and multiple pseudogenes of this gene have been identified. Co-transcription of this gene and the neighboring upstream gene generates a rare transcript (Kua-UEV), which encodes a fusion protein comprised of sequence sharing identity with each individual gene product. [provided by RefSeq, Apr 2012]. Gencode Transcript: ENST00000617119.4 Gencode Gene: ENSG00000244687.11 Transcript (Including UTRs) Position: hg38 chr20:50,081,124-50,113,198 Size: 32,075 Total Exon Count: 5 Strand: - Coding Region Position: hg38 chr20:50,082,768-50,096,716 Size: 13,949 Coding Exon Count: 3
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
Pfam Domains: PF10520 - B domain of TMEM189, localisation domain PF00179 - Ubiquitin-conjugating enzyme
ModBase Predicted Comparative 3D Structure on G3V2F7
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.