Human Gene KIZ (ENST00000616848.4) Description and Page Index
Description: Homo sapiens kizuna centrosomal protein (KIZ), transcript variant 3, mRNA. (from RefSeq NM_001163023) RefSeq Summary (NM_001163023): The protein encoded by this gene localizes to centrosomes, strengthening and stabilizing the pericentriolar region prior to spindle formation. The encoded protein usually remains with the mother centrosome after centrosomal duplication. Sevral transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Feb 2013]. ##Evidence-Data-START## Transcript exon combination :: SRR3476690.304899.1, AK293166.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1966682, SAMEA1968189 [ECO:0000348] ##Evidence-Data-END## Gencode Transcript: ENST00000616848.4 Gencode Gene: ENSG00000088970.16 Transcript (Including UTRs) Position: hg38 chr20:21,126,052-21,246,618 Size: 120,567 Total Exon Count: 11 Strand: + Coding Region Position: hg38 chr20:21,132,154-21,246,576 Size: 114,423 Coding Exon Count: 10
ID:KIZ_HUMAN DESCRIPTION: RecName: Full=Centrosomal protein kizuna; AltName: Full=Polo-like kinase 1 substrate 1; FUNCTION: Centrosomal protein required for establishing a robust mitotic centrosome architecture that can endure the forces that converge on the centrosomes during spindle formation. Required for stabilizing the expanded pericentriolar material around the centriole. SUBUNIT: Interacts with AKAP9, CEP72, ODF2, PCNT and TUBGCP2. SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton, centrosome. Note=Localizes to centrosomes throughout the cell cycle. After centrosome duplication, it usually remains associated only with the mother centrosome, containing the older mature centriole and particles surrounding it. During prophase, additional particles accumulate around both separating centrosomes. Does not accumulate at the microtubule minus ends, but instead localizes to the centrosomes and centrosome-surrounding area in a microtubule- independent and dependent manner, respectively. PTM: Phosphorylation at Thr-379 by PLK1 is not needed for centrosomal localization or pericentriolar material expansion but is indispensable for spindle-pole stabilization. MISCELLANEOUS: Kizuna means 'bonds' in Japanese. SIMILARITY: Belongs to the kizuna family. SEQUENCE CAUTION: Sequence=AAF67652.1; Type=Frameshift; Positions=283; Sequence=AAH39296.1; Type=Frameshift; Positions=279; Sequence=AAP97689.1; Type=Frameshift; Positions=198; Sequence=BAG59066.1; Type=Erroneous initiation;
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on Q2M2Z5
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.