Human Gene ABCG4 (ENST00000615496.4) Description and Page Index
Description: Homo sapiens ATP binding cassette subfamily G member 4 (ABCG4), transcript variant 2, mRNA. (from RefSeq NM_001142505) RefSeq Summary (NM_001142505): The protein encoded by this gene is a member of the ATP-binding cassette (ABC) transporter superfamily. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). The encoded protein is a member of the White subfamily and plays an important role in cellular cholesterol homeostasis. This protein functions as either a homodimer or as a heterodimer with another ABC subfamily protein such as ABCG1. [provided by RefSeq, Jan 2017]. Gencode Transcript: ENST00000615496.4 Gencode Gene: ENSG00000172350.10 Transcript (Including UTRs) Position: hg38 chr11:119,149,513-119,161,436 Size: 11,924 Total Exon Count: 15 Strand: + Coding Region Position: hg38 chr11:119,149,966-119,161,106 Size: 11,141 Coding Exon Count: 14
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on Q9H172
The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.
Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.