Human Gene BID (ENST00000615414.4) Description and Page Index
Description: Homo sapiens BH3 interacting domain death agonist (BID), transcript variant 7, mRNA. (from RefSeq NM_001244572) RefSeq Summary (NM_001244572): This gene encodes a death agonist that heterodimerizes with either agonist BAX or antagonist BCL2, and thus regulate apoptosis. The encoded protein is a member of the BCL-2 family of cell death regulators. It is a mediator of mitochondrial damage induced by caspase-8 (CASP8); CASP8 cleaves this encoded protein, and the COOH-terminal part translocates to mitochondria where it triggers cytochrome c release. Multiple alternatively spliced transcript variants have been found, but the full-length nature of some variants has not been defined. [provided by RefSeq, Jan 2020]. Gencode Transcript: ENST00000615414.4 Gencode Gene: ENSG00000015475.18 Transcript (Including UTRs) Position: hg38 chr22:17,734,142-17,774,042 Size: 39,901 Total Exon Count: 4 Strand: - Coding Region Position: hg38 chr22:17,735,580-17,739,423 Size: 3,844 Coding Exon Count: 3
ID:BID_HUMAN DESCRIPTION: RecName: Full=BH3-interacting domain death agonist; AltName: Full=p22 BID; Short=BID; Contains: RecName: Full=BH3-interacting domain death agonist p15; AltName: Full=p15 BID; Contains: RecName: Full=BH3-interacting domain death agonist p13; AltName: Full=p13 BID; Contains: RecName: Full=BH3-interacting domain death agonist p11; AltName: Full=p11 BID; FUNCTION: The major proteolytic product p15 BID allows the release of cytochrome c (By similarity). Isoform 1, isoform 2 and isoform 4 induce ICE-like proteases and apoptosis. Isoform 3 does not induce apoptosis. Counters the protective effect of Bcl-2. SUBUNIT: Forms heterodimers either with the pro-apoptotic protein BAX or the anti-apoptotic protein Bcl-2 (By similarity). p15 BID interacts with ITCH. INTERACTION: Q07812:BAX; NbExp=14; IntAct=EBI-519672, EBI-516580; P10415:BCL2; NbExp=8; IntAct=EBI-519672, EBI-77694; Q07440:Bcl2a1 (xeno); NbExp=3; IntAct=EBI-519672, EBI-707754; Q07817-1:BCL2L1; NbExp=6; IntAct=EBI-519672, EBI-287195; Q92843:BCL2L2; NbExp=5; IntAct=EBI-519672, EBI-707714; Q03135:CAV1; NbExp=3; IntAct=EBI-519672, EBI-603614; SUBCELLULAR LOCATION: Cytoplasm (By similarity). Mitochondrion membrane (By similarity). Note=When uncleaved, it is predominantly cytoplasmic. SUBCELLULAR LOCATION: BH3-interacting domain death agonist p15: Mitochondrion membrane (By similarity). Note=Translocates to mitochondria as an integral membrane protein (By similarity). SUBCELLULAR LOCATION: BH3-interacting domain death agonist p13: Mitochondrion membrane (By similarity). Note=Associated with the mitochondrial membrane (By similarity). SUBCELLULAR LOCATION: Isoform 1: Cytoplasm. SUBCELLULAR LOCATION: Isoform 3: Cytoplasm. SUBCELLULAR LOCATION: Isoform 2: Mitochondrion membrane. Note=A significant proportion of isoform 2 localizes to mitochondria, it may be cleaved constitutively. TISSUE SPECIFICITY: Isoform 2 and isoform 3 are expressed in spleen, bone marrow, cerebral and cerebellar cortex. Isoform 2 is expressed in spleen, pancreas and placenta (at protein level). Isoform 3 is expressed in lung, pancreas and spleen (at protein level). Isoform 4 is expressed in lung and pancreas (at protein level). DOMAIN: Intact BH3 motif is required by BIK, BID, BAK, BAD and BAX for their pro-apoptotic activity and for their interaction with anti-apoptotic members of the Bcl-2 family. PTM: TNF-alpha induces a caspase-mediated cleavage of p22 BID into a major p15 and minor p13 and p11 products (By similarity). PTM: Phosphorylated upon DNA damage, probably by ATM or ATR. PTM: p15 BID is ubiquitinated by ITCH; ubiquitination results in proteasome-dependent degradation. SEQUENCE CAUTION: Sequence=AAH22072.2; Type=Erroneous initiation; WEB RESOURCE: Name=NIEHS-SNPs; URL="http://egp.gs.washington.edu/data/bid/";
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on P55957
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
Biological Process: GO:0001836 release of cytochrome c from mitochondria GO:0006626 protein targeting to mitochondrion GO:0006915 apoptotic process GO:0006919 activation of cysteine-type endopeptidase activity involved in apoptotic process GO:0008625 extrinsic apoptotic signaling pathway via death domain receptors GO:0008637 apoptotic mitochondrial changes GO:0010918 positive regulation of mitochondrial membrane potential GO:0032459 regulation of protein oligomerization GO:0032461 positive regulation of protein oligomerization GO:0032464 positive regulation of protein homooligomerization GO:0042127 regulation of cell proliferation GO:0042770 signal transduction in response to DNA damage GO:0042775 mitochondrial ATP synthesis coupled electron transport GO:0042981 regulation of apoptotic process GO:0043065 positive regulation of apoptotic process GO:0043066 negative regulation of apoptotic process GO:0051260 protein homooligomerization GO:0051402 neuron apoptotic process GO:0090150 establishment of protein localization to membrane GO:0090200 positive regulation of release of cytochrome c from mitochondria GO:0097191 extrinsic apoptotic signaling pathway GO:0097284 hepatocyte apoptotic process GO:0097345 mitochondrial outer membrane permeabilization GO:1900740 positive regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway GO:1901030 positive regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway GO:1902108 regulation of mitochondrial membrane permeability involved in apoptotic process GO:1902230 negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage GO:2000045 regulation of G1/S transition of mitotic cell cycle GO:2000271 positive regulation of fibroblast apoptotic process GO:2001235 positive regulation of apoptotic signaling pathway GO:2001238 positive regulation of extrinsic apoptotic signaling pathway GO:2001244 positive regulation of intrinsic apoptotic signaling pathway