Human Gene NDUFB5 (ENST00000611971.4) Description and Page Index
  Description: Homo sapiens NADH:ubiquinone oxidoreductase subunit B5 (NDUFB5), transcript variant 3, mRNA. (from RefSeq NM_001199958)
RefSeq Summary (NM_001199958): The protein encoded by this gene is a subunit of the multisubunit NADH:ubiquinone oxidoreductase (complex I). Mammalian complex I is composed of 45 different subunits. It locates at the mitochondrial inner membrane. This protein has NADH dehydrogenase activity and oxidoreductase activity. It transfers electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone. Three transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jan 2011].
Gencode Transcript: ENST00000611971.4
Gencode Gene: ENSG00000136521.13
Transcript (Including UTRs)
   Position: hg38 chr3:179,604,787-179,624,499 Size: 19,713 Total Exon Count: 5 Strand: +
Coding Region
   Position: hg38 chr3:179,604,816-179,623,985 Size: 19,170 Coding Exon Count: 5 

Page IndexSequence and LinksCTDRNA-Seq ExpressionMicroarray ExpressionRNA Structure
Other SpeciesmRNA DescriptionsPathwaysOther NamesMethods
Data last updated: 2019-09-04

-  Sequence and Links to Tools and Databases
 
Genomic Sequence (chr3:179,604,787-179,624,499)mRNA (may differ from genome)Protein (135 aa)
Gene SorterGenome BrowserOther Species FASTAGene interactionsTable SchemaBioGPS
CGAPEnsemblEntrez GeneExonPrimerGeneCardsHGNC
LynxMGIOMIMPubMedStanford SOURCEUniProtKB
Wikipedia

-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene           more ... click here to view the complete list

-  RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
  Highest median expression: 26.98 RPKM in Heart - Left Ventricle
Total median expression: 622.39 RPKM



View in GTEx track of Genome Browser    View at GTEx portal     View GTEx Body Map

+  Microarray Expression Data
  Press "+" in the title bar above to open this section.

-  mRNA Secondary Structure of 3' and 5' UTRs
 
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -1.6029-0.055 Picture PostScript Text
3' UTR -103.20514-0.201 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
Genome BrowserGenome BrowserNo orthologNo orthologNo orthologNo ortholog
Gene Details     
Gene Sorter     
MGIRGD    
Protein SequenceProtein Sequence    
AlignmentAlignment    

-  Descriptions from all associated GenBank mRNAs
  BX648034 - Homo sapiens mRNA; cDNA DKFZp686N02262 (from clone DKFZp686N02262).
BC005271 - Homo sapiens NADH dehydrogenase (ubiquinone) 1 beta subcomplex, 5, 16kDa, mRNA (cDNA clone MGC:12314 IMAGE:3997377), complete cds.
BC009796 - Homo sapiens NADH dehydrogenase (ubiquinone) 1 beta subcomplex, 5, 16kDa, mRNA (cDNA clone MGC:13617 IMAGE:4284776), complete cds.
JD026494 - Sequence 7518 from Patent EP1572962.
AK313822 - Homo sapiens cDNA, FLJ94443, highly similar to Homo sapiens NADH dehydrogenase (ubiquinone) 1 beta subcomplex, 5, 16kDa (NDUFB5), mRNA.
BC093071 - Homo sapiens NADH dehydrogenase (ubiquinone) 1 beta subcomplex, 5, 16kDa, mRNA (cDNA clone MGC:111204 IMAGE:30325282), complete cds.
AF047181 - Homo sapiens NADH-ubiquinone oxidoreductase subunit CI-SGDH mRNA, complete cds.
JD024279 - Sequence 5303 from Patent EP1572962.
BC017909 - Homo sapiens NADH dehydrogenase (ubiquinone) 1 beta subcomplex, 5, 16kDa, mRNA (cDNA clone IMAGE:4278928), complete cds.
JD034164 - Sequence 15188 from Patent EP1572962.
JD034163 - Sequence 15187 from Patent EP1572962.
HQ448677 - Synthetic construct Homo sapiens clone IMAGE:100072119; CCSB006438_01 NADH dehydrogenase (ubiquinone) 1 beta subcomplex, 5, 16kDa (NDUFB5) gene, encodes complete protein.
KJ891677 - Synthetic construct Homo sapiens clone ccsbBroadEn_01071 NDUFB5 gene, encodes complete protein.
CU679497 - Synthetic construct Homo sapiens gateway clone IMAGE:100018003 5' read NDUFB5 mRNA.
JD306192 - Sequence 287216 from Patent EP1572962.
JD501825 - Sequence 482849 from Patent EP1572962.
JD036481 - Sequence 17505 from Patent EP1572962.
JD357366 - Sequence 338390 from Patent EP1572962.
JD445888 - Sequence 426912 from Patent EP1572962.
JD484330 - Sequence 465354 from Patent EP1572962.

-  Biochemical and Signaling Pathways
  KEGG - Kyoto Encyclopedia of Genes and Genomes
hsa00190 - Oxidative phosphorylation
hsa01100 - Metabolic pathways
hsa05010 - Alzheimer's disease
hsa05012 - Parkinson's disease
hsa05016 - Huntington's disease

-  Other Names for This Gene
  Alternate Gene Symbols: A0A087WYD0, NM_001199958, uc021xhu.1, uc021xhu.2
UCSC ID: uc021xhu.2
RefSeq Accession: NM_001199958
CCDS: CCDS75054.1

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.