Human Gene DHRS2 (ENST00000611765.4) Description and Page Index
  Description: Displays NADPH-dependent dicarbonyl reductase activity in vitro with 3,4-Hexanedione, 2,3-Heptanedione and 1-Phenyl-1,2- propanedione as substrates. No reductase activity is displayed in vitro with steroids, retinoids and sugars as substrates. May inhibit cell replication. (from UniProt Q13268)
RefSeq Summary (NM_182908): This gene encodes a member of the short-chain dehydrogenases/reductases (SDR) family, which has over 46,000 members. Members of this family are enzymes that metabolize many different compounds, such as steroid hormones, prostaglandins, retinoids, lipids and xenobiotics. Alternative promoter use and alternative splicing results in multiple transcript variants. [provided by RefSeq, Feb 2017].
Gencode Transcript: ENST00000611765.4
Gencode Gene: ENSG00000100867.14
Transcript (Including UTRs)
   Position: hg38 chr14:23,638,816-23,645,637 Size: 6,822 Total Exon Count: 8 Strand: +
Coding Region
   Position: hg38 chr14:23,638,865-23,645,302 Size: 6,438 Coding Exon Count: 8 

Page IndexSequence and LinksUniProtKB CommentsCTDRNA-Seq ExpressionMicroarray Expression
RNA StructureProtein StructureOther SpeciesGO AnnotationsmRNA DescriptionsOther Names
Data last updated: 2019-09-04

-  Sequence and Links to Tools and Databases
Genomic Sequence (chr14:23,638,816-23,645,637)mRNA (may differ from genome)Protein (300 aa)
Gene SorterGenome BrowserOther Species FASTAGene interactionsTable SchemaBioGPS
LynxMGIneXtProtPubMedStanford SOURCEUniProtKB

-  Comments and Description Text from UniProtKB
DESCRIPTION: RecName: Full=Dehydrogenase/reductase SDR family member 2; EC=1.1.1.-; AltName: Full=Dicarbonyl reductase HEP27; AltName: Full=Protein D;
FUNCTION: Displays NADPH-dependent dicarbonyl reductase activity in vitro with 3,4-Hexanedione, 2,3-Heptanedione and 1-Phenyl-1,2- propanedione as substrates. No reductase activity is displayed in vitro with steroids, retinoids and sugars as substrates. May inhibit cell replication.
BIOPHYSICOCHEMICAL PROPERTIES: Kinetic parameters: KM=0.3 mM for 1-Phenyl-1,2-propanedione; KM=1.1 mM for 2,3-Heptanedione; KM=0.8 mM for 3,4-Hexanedione; Vmax=0.52 mmol/min/mg enzyme with 1-Phenyl-1,2-propanedione as substrate; Vmax=0.64 mmol/min/mg enzyme with 2,3-Heptanedione as substrate; Vmax=0.35 mmol/min/mg enzyme with 3,4-Hexanedione as substrate;
SIMILARITY: Belongs to the short-chain dehydrogenases/reductases (SDR) family.
SEQUENCE CAUTION: Sequence=AAA82048.1; Type=Erroneous initiation; Sequence=AAG33703.1; Type=Erroneous initiation; Sequence=AAH07339.2; Type=Erroneous initiation; Sequence=BAD96577.1; Type=Erroneous initiation;

-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene
  • C100349 1-phenyl-1,2-propanedione
  • C029497 2,3-bis(3'-hydroxybenzyl)butyrolactone
  • C049584 2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine
  • C036990 2-amino-3,8-dimethylimidazo(4,5-f)quinoxaline
  • D015124 8-Bromo Cyclic Adenosine Monophosphate
  • D000082 Acetaminophen
  • D016604 Aflatoxin B1
  • D000638 Amiodarone
  • D017638 Asbestos, Crocidolite
  • D001564 Benzo(a)pyrene
          more ... click here to view the complete list

-  RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
  Highest median expression: 263.63 RPKM in Bladder
Total median expression: 294.52 RPKM

View in GTEx track of Genome Browser    View at GTEx portal     View GTEx Body Map

+  Microarray Expression Data
  Press "+" in the title bar above to open this section.

-  mRNA Secondary Structure of 3' and 5' UTRs
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -4.9049-0.100 Picture PostScript Text
3' UTR -100.70335-0.301 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  InterPro Domains: Graphical view of domain structure
IPR002198 - DH_sc/Rdtase_SDR
IPR002347 - Glc/ribitol_DH
IPR016040 - NAD(P)-bd_dom
IPR020904 - Sc_DH/Rdtase_CS

ModBase Predicted Comparative 3D Structure on Q13268
The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
Genome BrowserGenome BrowserNo orthologNo orthologNo orthologNo ortholog
Gene Details     
Gene Sorter     
Protein SequenceProtein Sequence    

-  Gene Ontology (GO) Annotations with Structured Vocabulary
  Molecular Function:
GO:0004090 carbonyl reductase (NADPH) activity
GO:0005515 protein binding
GO:0016491 oxidoreductase activity

Biological Process:
GO:0008207 C21-steroid hormone metabolic process
GO:0008285 negative regulation of cell proliferation
GO:0009636 response to toxic substance
GO:0034599 cellular response to oxidative stress
GO:0043011 myeloid dendritic cell differentiation
GO:0043066 negative regulation of apoptotic process
GO:0055114 oxidation-reduction process

Cellular Component:
GO:0005634 nucleus
GO:0005635 nuclear envelope
GO:0005737 cytoplasm
GO:0005739 mitochondrion
GO:0005759 mitochondrial matrix

-  Descriptions from all associated GenBank mRNAs
  CU678196 - Synthetic construct Homo sapiens gateway clone IMAGE:100022445 5' read DHRS2 mRNA.
AK309975 - Homo sapiens cDNA, FLJ17017.
AK222857 - Homo sapiens mRNA for dehydrogenase/reductase (SDR family) member 2 isoform 2 variant, clone: HEP13658.
AK309945 - Homo sapiens cDNA, FLJ99986.
BC002786 - Homo sapiens dehydrogenase/reductase (SDR family) member 2, mRNA (cDNA clone MGC:3575 IMAGE:3614599), complete cds.
U31875 - Human Hep27 protein mRNA, complete cds.
AB209653 - Homo sapiens mRNA for dehydrogenase/reductase (SDR family) member 2 isoform 2 variant protein.
JD497417 - Sequence 478441 from Patent EP1572962.
JD287764 - Sequence 268788 from Patent EP1572962.
JD333808 - Sequence 314832 from Patent EP1572962.
HQ448428 - Synthetic construct Homo sapiens clone IMAGE:100071856; CCSB013424_02 dehydrogenase/reductase (SDR family) member 2 (DHRS2) gene, encodes complete protein.
KJ892957 - Synthetic construct Homo sapiens clone ccsbBroadEn_02351 DHRS2 gene, encodes complete protein.
BC007339 - Homo sapiens dehydrogenase/reductase (SDR family) member 2, mRNA (cDNA clone IMAGE:3833714), partial cds.
CU675623 - Synthetic construct Homo sapiens gateway clone IMAGE:100018632 5' read DHRS2 mRNA.
KJ902074 - Synthetic construct Homo sapiens clone ccsbBroadEn_11468 DHRS2 gene, encodes complete protein.
AK092834 - Homo sapiens cDNA FLJ35515 fis, clone SPLEN2000630, highly similar to HEP27 PROTEIN.
AK000345 - Homo sapiens cDNA FLJ20338 fis, clone HEP12179.
JD217656 - Sequence 198680 from Patent EP1572962.
JD388088 - Sequence 369112 from Patent EP1572962.
JD565478 - Sequence 546502 from Patent EP1572962.
JD213810 - Sequence 194834 from Patent EP1572962.

-  Other Names for This Gene
  Alternate Gene Symbols: BC002786, DHRS2_HUMAN, Q13268, Q53GS4, Q7Z789, Q9H2R2, uc058ztm.1
UCSC ID: uc058ztm.1
RefSeq Accession: NM_182908
Protein: Q13268 (aka DHRS2_HUMAN or DHS2_HUMAN)
CCDS: CCDS41927.1

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.