Human Gene DHRS2 (ENST00000611765.4) Description and Page Index
Description: Displays NADPH-dependent dicarbonyl reductase activity in vitro with 3,4-Hexanedione, 2,3-Heptanedione and 1-Phenyl-1,2- propanedione as substrates. No reductase activity is displayed in vitro with steroids, retinoids and sugars as substrates. May inhibit cell replication. (from UniProt Q13268) RefSeq Summary (NM_182908): This gene encodes a member of the short-chain dehydrogenases/reductases (SDR) family, which has over 46,000 members. Members of this family are enzymes that metabolize many different compounds, such as steroid hormones, prostaglandins, retinoids, lipids and xenobiotics. Alternative promoter use and alternative splicing results in multiple transcript variants. [provided by RefSeq, Feb 2017]. Gencode Transcript: ENST00000611765.4 Gencode Gene: ENSG00000100867.14 Transcript (Including UTRs) Position: hg38 chr14:23,638,816-23,645,637 Size: 6,822 Total Exon Count: 8 Strand: + Coding Region Position: hg38 chr14:23,638,865-23,645,302 Size: 6,438 Coding Exon Count: 8
ID:DHRS2_HUMAN DESCRIPTION: RecName: Full=Dehydrogenase/reductase SDR family member 2; EC=1.1.1.-; AltName: Full=Dicarbonyl reductase HEP27; AltName: Full=Protein D; FUNCTION: Displays NADPH-dependent dicarbonyl reductase activity in vitro with 3,4-Hexanedione, 2,3-Heptanedione and 1-Phenyl-1,2- propanedione as substrates. No reductase activity is displayed in vitro with steroids, retinoids and sugars as substrates. May inhibit cell replication. BIOPHYSICOCHEMICAL PROPERTIES: Kinetic parameters: KM=0.3 mM for 1-Phenyl-1,2-propanedione; KM=1.1 mM for 2,3-Heptanedione; KM=0.8 mM for 3,4-Hexanedione; Vmax=0.52 mmol/min/mg enzyme with 1-Phenyl-1,2-propanedione as substrate; Vmax=0.64 mmol/min/mg enzyme with 2,3-Heptanedione as substrate; Vmax=0.35 mmol/min/mg enzyme with 3,4-Hexanedione as substrate; SUBCELLULAR LOCATION: Nucleus. SIMILARITY: Belongs to the short-chain dehydrogenases/reductases (SDR) family. SEQUENCE CAUTION: Sequence=AAA82048.1; Type=Erroneous initiation; Sequence=AAG33703.1; Type=Erroneous initiation; Sequence=AAH07339.2; Type=Erroneous initiation; Sequence=BAD96577.1; Type=Erroneous initiation;
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on Q13268
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.