Human Gene ZNF282 (ENST00000610704.5) Description and Page Index
  Description: Homo sapiens zinc finger protein 282 (ZNF282), transcript variant 1, mRNA. (from RefSeq NM_003575)
Gencode Transcript: ENST00000610704.5
Gencode Gene: ENSG00000170265.12
Transcript (Including UTRs)
   Position: hg38 chr7:149,195,546-149,226,238 Size: 30,693 Total Exon Count: 8 Strand: +
Coding Region
   Position: hg38 chr7:149,195,590-149,224,647 Size: 29,058 Coding Exon Count: 8 

Page IndexSequence and LinksUniProtKB CommentsCTDMicroarray ExpressionRNA Structure
Protein StructureOther SpeciesGO AnnotationsmRNA DescriptionsPathwaysOther Names
Methods
Data last updated: 2019-09-04

-  Sequence and Links to Tools and Databases
 
Genomic Sequence (chr7:149,195,546-149,226,238)mRNA (may differ from genome)Protein (671 aa)
Gene SorterGenome BrowserOther Species FASTAGene interactionsTable SchemaBioGPS
CGAPEnsemblEntrez GeneExonPrimerGeneCardsHGNC
HPRDLynxMGIneXtProtOMIMPubMed
ReactomeStanford SOURCEUniProtKB

-  Comments and Description Text from UniProtKB
  ID: ZN282_HUMAN
DESCRIPTION: RecName: Full=Zinc finger protein 282; AltName: Full=HTLV-I U5RE-binding protein 1; Short=HUB-1;
FUNCTION: Binds to the U5 repressive element (U5RE) of the human T cell leukemia virus type I long terminal repeat. It recognizes the 5'-TCCACCCC-3' sequence as a core motif and exerts a strong repressive effect on HTLV-I LTR-mediated expression.
SUBCELLULAR LOCATION: Nucleus (Probable).
TISSUE SPECIFICITY: Ubiquitous.
SIMILARITY: Belongs to the krueppel C2H2-type zinc-finger protein family.
SIMILARITY: Contains 5 C2H2-type zinc fingers.
SIMILARITY: Contains 1 KRAB domain.
SEQUENCE CAUTION: Sequence=BAA24380.1; Type=Erroneous initiation;

-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene

+  Microarray Expression Data
  Press "+" in the title bar above to open this section.

-  mRNA Secondary Structure of 3' and 5' UTRs
 
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -10.5044-0.239 Picture PostScript Text
3' UTR -682.501591-0.429 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  InterPro Domains: Graphical view of domain structure
IPR022137 - DUF3669_Znf
IPR001909 - Krueppel-associated_box
IPR007087 - Znf_C2H2
IPR015880 - Znf_C2H2-like
IPR013087 - Znf_C2H2/integrase_DNA-bd

Pfam Domains:
PF12417 - Zinc finger protein
PF01352 - KRAB box

ModBase Predicted Comparative 3D Structure on Q9UDV7
FrontTopSide
The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
Genome BrowserGenome BrowserNo orthologNo orthologNo orthologNo ortholog
Gene Details     
Gene Sorter     
MGIRGD    
Protein SequenceProtein Sequence    
AlignmentAlignment    

-  Gene Ontology (GO) Annotations with Structured Vocabulary
  Molecular Function:
GO:0000981 RNA polymerase II transcription factor activity, sequence-specific DNA binding
GO:0003676 nucleic acid binding
GO:0003677 DNA binding
GO:0008270 zinc ion binding
GO:0046872 metal ion binding

Biological Process:
GO:0006351 transcription, DNA-templated
GO:0006355 regulation of transcription, DNA-templated
GO:0006357 regulation of transcription from RNA polymerase II promoter
GO:0045892 negative regulation of transcription, DNA-templated

Cellular Component:
GO:0005622 intracellular
GO:0005634 nucleus


-  Descriptions from all associated GenBank mRNAs
  D30612 - Homo sapiens mRNA for repressor protein, partial cds.
LF384106 - JP 2014500723-A/191609: Polycomb-Associated Non-Coding RNAs.
MA619683 - JP 2018138019-A/191609: Polycomb-Associated Non-Coding RNAs.
AK299280 - Homo sapiens cDNA FLJ54307 complete cds, highly similar to Zinc finger protein 282.
BC073805 - Homo sapiens zinc finger protein 282, mRNA (cDNA clone MGC:88828 IMAGE:6645861), complete cds.
JD039990 - Sequence 21014 from Patent EP1572962.
AK316282 - Homo sapiens cDNA, FLJ79181 complete cds, highly similar to Zinc finger protein 282.
AB587508 - Synthetic construct DNA, clone: pF1KB9774, Homo sapiens ZNF282 gene for zinc finger protein 282, without stop codon, in Flexi system.
BC055287 - Homo sapiens zinc finger protein 282, mRNA (cDNA clone IMAGE:6188941), partial cds.
BC041704 - Homo sapiens, Similar to expressed sequence AI449432, clone IMAGE:5502132, mRNA, partial cds.
AY927505 - Homo sapiens mRNA sequence.
BC031686 - Homo sapiens zinc finger protein 282, mRNA (cDNA clone IMAGE:4932317), partial cds.
JD240423 - Sequence 221447 from Patent EP1572962.
AY927504 - Homo sapiens mRNA sequence.
LF362180 - JP 2014500723-A/169683: Polycomb-Associated Non-Coding RNAs.
MA597757 - JP 2018138019-A/169683: Polycomb-Associated Non-Coding RNAs.
LF362181 - JP 2014500723-A/169684: Polycomb-Associated Non-Coding RNAs.
MA597758 - JP 2018138019-A/169684: Polycomb-Associated Non-Coding RNAs.
JD053522 - Sequence 34546 from Patent EP1572962.
JD095009 - Sequence 76033 from Patent EP1572962.
JD040182 - Sequence 21206 from Patent EP1572962.
JD396360 - Sequence 377384 from Patent EP1572962.
JD463696 - Sequence 444720 from Patent EP1572962.
JD371907 - Sequence 352931 from Patent EP1572962.
JD322030 - Sequence 303054 from Patent EP1572962.
JD398513 - Sequence 379537 from Patent EP1572962.
JD216248 - Sequence 197272 from Patent EP1572962.
JD503396 - Sequence 484420 from Patent EP1572962.
JD214589 - Sequence 195613 from Patent EP1572962.
JD135450 - Sequence 116474 from Patent EP1572962.
JD418981 - Sequence 400005 from Patent EP1572962.
JD076902 - Sequence 57926 from Patent EP1572962.
JD427178 - Sequence 408202 from Patent EP1572962.
JD262365 - Sequence 243389 from Patent EP1572962.
JD251300 - Sequence 232324 from Patent EP1572962.
BC009542 - Homo sapiens cDNA clone IMAGE:3895779.
JD507603 - Sequence 488627 from Patent EP1572962.
JD443618 - Sequence 424642 from Patent EP1572962.
JD465245 - Sequence 446269 from Patent EP1572962.
JD137486 - Sequence 118510 from Patent EP1572962.
JD541641 - Sequence 522665 from Patent EP1572962.
JD369683 - Sequence 350707 from Patent EP1572962.

-  Biochemical and Signaling Pathways
  Reactome (by CSHL, EBI, and GO)

Protein Q9UDV7 (Reactome details) participates in the following event(s):

R-HSA-975040 KRAB-ZNF / KAP Interaction
R-HSA-212436 Generic Transcription Pathway
R-HSA-73857 RNA Polymerase II Transcription
R-HSA-74160 Gene expression (Transcription)

-  Other Names for This Gene
  Alternate Gene Symbols: HUB1, NM_003575, O43691, Q6DKK0, Q9UDV7, uc033apc.1, uc033apc.2, ZN282_HUMAN
UCSC ID: uc033apc.2
RefSeq Accession: NM_003575
Protein: Q9UDV7 (aka ZN282_HUMAN or Z282_HUMAN)
CCDS: CCDS5895.1

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.