Human Gene HNRNPUL1 (ENST00000593587.5) Description and Page Index
Description: Homo sapiens heterogeneous nuclear ribonucleoprotein U like 1 (HNRNPUL1), transcript variant 7, mRNA. (from RefSeq NM_001321211) RefSeq Summary (NM_001321211): This gene encodes a nuclear RNA-binding protein of the heterogeneous nuclear ribonucleoprotein (hnRNP) family. This protein binds specifically to adenovirus early-1B-55kDa oncoprotein. It may play an important role in nucleocytoplasmic RNA transport, and its function is modulated by early-1B-55kDa in adenovirus-infected cells. [provided by RefSeq, Mar 2016]. Sequence Note: This RefSeq record was created from transcript and genomic sequence data to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AK290729.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA2142586, SAMEA2142853 [ECO:0000348] ##Evidence-Data-END## Gencode Transcript: ENST00000593587.5 Gencode Gene: ENSG00000105323.17 Transcript (Including UTRs) Position: hg38 chr19:41,265,079-41,306,925 Size: 41,847 Total Exon Count: 15 Strand: + Coding Region Position: hg38 chr19:41,268,228-41,306,565 Size: 38,338 Coding Exon Count: 14
ID:HNRL1_HUMAN DESCRIPTION: RecName: Full=Heterogeneous nuclear ribonucleoprotein U-like protein 1; AltName: Full=Adenovirus early region 1B-associated protein 5; AltName: Full=E1B-55 kDa-associated protein 5; Short=E1B-AP5; FUNCTION: Acts as a basic transcriptional regulator. Represses basic transcription driven by several virus and cellular promoters. When associated with BRD7, activates transcription of glucocorticoid-responsive promoter in the absence of ligand- stimulation. Plays also a role in mRNA processing and transport. Binds avidly to poly(G) and poly(C) RNA homopolymers in vitro. SUBUNIT: Interacts with the adenovirus type 5 (Ad5) E1B-55 kDa, BRD7, PRMT2, TP53 and NXF1. Associates with histones and BRD7. INTERACTION: P04637:TP53; NbExp=11; IntAct=EBI-1018153, EBI-366083; SUBCELLULAR LOCATION: Nucleus. DOMAIN: The RGG-box domain is methylated. PTM: Methylated. MISCELLANEOUS: Its methylation is enhanced in the late phase of adenoviral infection. SIMILARITY: Contains 1 B30.2/SPRY domain. SIMILARITY: Contains 1 SAP domain.
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on Q9BUJ2
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.