Human Gene TNPO2 (ENST00000588216.5) Description and Page Index
  Description: Homo sapiens transportin 2 (TNPO2), transcript variant 3, mRNA. (from RefSeq NM_001136195)
Gencode Transcript: ENST00000588216.5
Gencode Gene: ENSG00000105576.15
Transcript (Including UTRs)
   Position: hg38 chr19:12,701,327-12,724,011 Size: 22,685 Total Exon Count: 25 Strand: -
Coding Region
   Position: hg38 chr19:12,701,346-12,720,977 Size: 19,632 Coding Exon Count: 23 

Page IndexSequence and LinksUniProtKB CommentsCTDRNA-Seq ExpressionMicroarray Expression
RNA StructureProtein StructureOther SpeciesGO AnnotationsmRNA DescriptionsOther Names
Data last updated: 2019-09-04

-  Sequence and Links to Tools and Databases
Genomic Sequence (chr19:12,701,327-12,724,011)mRNA (may differ from genome)Protein (887 aa)
Gene SorterGenome BrowserOther Species FASTAGene interactionsTable SchemaBioGPS
CGAPEnsemblEntrez GeneExonPrimerGeneCardsHGNC
Stanford SOURCEUniProtKBWikipedia

-  Comments and Description Text from UniProtKB
DESCRIPTION: RecName: Full=Transportin-2; AltName: Full=Karyopherin beta-2b;
FUNCTION: Probably functions in nuclear protein import as nuclear transport receptor. Serves as receptor for nuclear localization signals (NLS) in cargo substrates. Is thought to mediate docking of the importin/substrate complex to the nuclear pore complex (NPC) through binding to nucleoporin and the complex is subsequently translocated through the pore by an energy requiring, Ran-dependent mechanism. At the nucleoplasmic side of the NPC, Ran binds to the importin, the importin/substrate complex dissociates and importin is re-exported from the nucleus to the cytoplasm where GTP hydrolysis releases Ran. The directionality of nuclear import is thought to be conferred by an asymmetric distribution of the GTP- and GDP-bound forms of Ran between the cytoplasm and nucleus (By similarity).
SUBCELLULAR LOCATION: Cytoplasm (By similarity). Nucleus (By similarity).
SIMILARITY: Belongs to the importin beta family.
SIMILARITY: Contains 13 HEAT repeats.
SIMILARITY: Contains 1 importin N-terminal domain.

-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene           more ... click here to view the complete list

-  RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
  Highest median expression: 38.50 RPKM in Brain - Cortex
Total median expression: 991.52 RPKM

View in GTEx track of Genome Browser    View at GTEx portal     View GTEx Body Map

+  Microarray Expression Data
  Press "+" in the title bar above to open this section.

-  mRNA Secondary Structure of 3' and 5' UTRs
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -120.60373-0.323 Picture PostScript Text
3' UTR -1.1019-0.058 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  InterPro Domains: Graphical view of domain structure
IPR011989 - ARM-like
IPR016024 - ARM-type_fold
IPR000357 - HEAT
IPR001494 - Importin-beta_N

Pfam Domains:
PF02985 - HEAT repeat
PF03810 - Importin-beta N-terminal domain

ModBase Predicted Comparative 3D Structure on O14787
The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
Genome BrowserGenome BrowserNo orthologNo orthologNo orthologNo ortholog
Gene Details     
Gene Sorter     
Protein SequenceProtein Sequence    

-  Gene Ontology (GO) Annotations with Structured Vocabulary
  Molecular Function:
GO:0005515 protein binding
GO:0008139 nuclear localization sequence binding
GO:0008536 Ran GTPase binding
GO:0008565 protein transporter activity

Biological Process:
GO:0000060 protein import into nucleus, translocation
GO:0006607 NLS-bearing protein import into nucleus
GO:0006610 ribosomal protein import into nucleus
GO:0006886 intracellular protein transport
GO:0015031 protein transport

Cellular Component:
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0031965 nuclear membrane
GO:0034399 nuclear periphery

-  Descriptions from all associated GenBank mRNAs
  AK056183 - Homo sapiens cDNA FLJ31621 fis, clone NT2RI2003205, highly similar to Transportin-2.
LF208193 - JP 2014500723-A/15696: Polycomb-Associated Non-Coding RNAs.
MA443770 - JP 2018138019-A/15696: Polycomb-Associated Non-Coding RNAs.
BC072420 - Homo sapiens transportin 2, mRNA (cDNA clone MGC:90166 IMAGE:6184325), complete cds.
AB210011 - Homo sapiens mRNA for TNPO2 variant protein, clone: fh13310.
AK299485 - Homo sapiens cDNA FLJ54538 complete cds, highly similar to Transportin-2.
AF019039 - Homo sapiens transportin2 mRNA, complete cds.
AF007748 - Homo sapiens karyopherin beta2b homolog mRNA, complete cds.
KJ898764 - Synthetic construct Homo sapiens clone ccsbBroadEn_08158 TNPO2 gene, encodes complete protein.
AB384365 - Synthetic construct DNA, clone: pF1KSDB0027, Homo sapiens TNPO2 gene for transportin-2, complete cds, without stop codon, in Flexi system.
BC018314 - Homo sapiens transportin 2, mRNA (cDNA clone IMAGE:4154236), partial cds.
BC063679 - Homo sapiens transportin 2, mRNA (cDNA clone IMAGE:4358892), **** WARNING: chimeric clone ****.
LF208194 - JP 2014500723-A/15697: Polycomb-Associated Non-Coding RNAs.
MA443771 - JP 2018138019-A/15697: Polycomb-Associated Non-Coding RNAs.
AK307632 - Homo sapiens cDNA, FLJ97580.
LF373398 - JP 2014500723-A/180901: Polycomb-Associated Non-Coding RNAs.
MA608975 - JP 2018138019-A/180901: Polycomb-Associated Non-Coding RNAs.
AK022217 - Homo sapiens cDNA FLJ12155 fis, clone MAMMA1000472.
LF373396 - JP 2014500723-A/180899: Polycomb-Associated Non-Coding RNAs.
MA608973 - JP 2018138019-A/180899: Polycomb-Associated Non-Coding RNAs.
DQ597131 - Homo sapiens piRNA piR-35197, complete sequence.
LF373394 - JP 2014500723-A/180897: Polycomb-Associated Non-Coding RNAs.
MA608971 - JP 2018138019-A/180897: Polycomb-Associated Non-Coding RNAs.
LF373393 - JP 2014500723-A/180896: Polycomb-Associated Non-Coding RNAs.
MA608970 - JP 2018138019-A/180896: Polycomb-Associated Non-Coding RNAs.
LF373392 - JP 2014500723-A/180895: Polycomb-Associated Non-Coding RNAs.
MA608969 - JP 2018138019-A/180895: Polycomb-Associated Non-Coding RNAs.
LF373391 - JP 2014500723-A/180894: Polycomb-Associated Non-Coding RNAs.
MA608968 - JP 2018138019-A/180894: Polycomb-Associated Non-Coding RNAs.
DQ583614 - Homo sapiens piRNA piR-50726, complete sequence.
LF373390 - JP 2014500723-A/180893: Polycomb-Associated Non-Coding RNAs.
MA608967 - JP 2018138019-A/180893: Polycomb-Associated Non-Coding RNAs.
LF373389 - JP 2014500723-A/180892: Polycomb-Associated Non-Coding RNAs.
MA608966 - JP 2018138019-A/180892: Polycomb-Associated Non-Coding RNAs.
LF373387 - JP 2014500723-A/180890: Polycomb-Associated Non-Coding RNAs.
MA608964 - JP 2018138019-A/180890: Polycomb-Associated Non-Coding RNAs.
LF373386 - JP 2014500723-A/180889: Polycomb-Associated Non-Coding RNAs.
MA608963 - JP 2018138019-A/180889: Polycomb-Associated Non-Coding RNAs.
DQ575753 - Homo sapiens piRNA piR-43865, complete sequence.
LF373385 - JP 2014500723-A/180888: Polycomb-Associated Non-Coding RNAs.
MA608962 - JP 2018138019-A/180888: Polycomb-Associated Non-Coding RNAs.
CU687228 - Synthetic construct Homo sapiens gateway clone IMAGE:100023241 5' read TNPO2 mRNA.
DQ598577 - Homo sapiens piRNA piR-36643, complete sequence.
DQ573763 - Homo sapiens piRNA piR-41875, complete sequence.
LF373383 - JP 2014500723-A/180886: Polycomb-Associated Non-Coding RNAs.
MA608960 - JP 2018138019-A/180886: Polycomb-Associated Non-Coding RNAs.
JD297924 - Sequence 278948 from Patent EP1572962.
JD182422 - Sequence 163446 from Patent EP1572962.
JD361833 - Sequence 342857 from Patent EP1572962.
JD059281 - Sequence 40305 from Patent EP1572962.

-  Other Names for This Gene
  Alternate Gene Symbols: NM_001136195, O14655, O14787, Q6IN77, TNPO2_HUMAN, uc060ubq.1
UCSC ID: uc060ubq.1
RefSeq Accession: NM_001136195
Protein: O14787 (aka TNPO2_HUMAN or TNP2_HUMAN)
CCDS: CCDS45991.1, CCDS45992.1

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.