Human Gene CD226 (ENST00000581982.5) Description and Page Index
Description: Homo sapiens CD226 molecule (CD226), transcript variant 3, mRNA. (from RefSeq NM_001303619) RefSeq Summary (NM_001303619): This gene encodes a glycoprotein expressed on the surface of NK cells, platelets, monocytes and a subset of T cells. It is a member of the Ig-superfamily containing 2 Ig-like domains of the V-set. The protein mediates cellular adhesion of platelets and megakaryocytic cells to vascular endothelial cells. The protein also plays a role in megakaryocytic cell maturation. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2015]. Gencode Transcript: ENST00000581982.5 Gencode Gene: ENSG00000150637.9 Transcript (Including UTRs) Position: hg38 chr18:69,862,956-69,956,924 Size: 93,969 Total Exon Count: 5 Strand: - Coding Region Position: hg38 chr18:69,864,314-69,895,962 Size: 31,649 Coding Exon Count: 4
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on J3QR77
The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.
Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.