Human Gene CD226 (ENST00000581982.5) Description and Page Index
  Description: Homo sapiens CD226 molecule (CD226), transcript variant 3, mRNA. (from RefSeq NM_001303619)
RefSeq Summary (NM_001303619): This gene encodes a glycoprotein expressed on the surface of NK cells, platelets, monocytes and a subset of T cells. It is a member of the Ig-superfamily containing 2 Ig-like domains of the V-set. The protein mediates cellular adhesion of platelets and megakaryocytic cells to vascular endothelial cells. The protein also plays a role in megakaryocytic cell maturation. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2015].
Gencode Transcript: ENST00000581982.5
Gencode Gene: ENSG00000150637.9
Transcript (Including UTRs)
   Position: hg38 chr18:69,862,956-69,956,924 Size: 93,969 Total Exon Count: 5 Strand: -
Coding Region
   Position: hg38 chr18:69,864,314-69,895,962 Size: 31,649 Coding Exon Count: 4 

Page IndexSequence and LinksUniProtKB CommentsMalaCardsCTDRNA-Seq Expression
Microarray ExpressionRNA StructureProtein StructureOther SpeciesGO AnnotationsmRNA Descriptions
PathwaysOther NamesMethods
Data last updated: 2019-09-04

-  Sequence and Links to Tools and Databases
Genomic Sequence (chr18:69,862,956-69,956,924)mRNA (may differ from genome)Protein (181 aa)
Gene SorterGenome BrowserOther Species FASTAGene interactionsTable SchemaBioGPS
CGAPEnsemblEntrez GeneExonPrimerGeneCardsHGNC

-  Comments and Description Text from UniProtKB
DESCRIPTION: SubName: Full=CD226 antigen;
CAUTION: The sequence shown here is derived from an Ensembl automatic analysis pipeline and should be considered as preliminary data.

-  MalaCards Disease Associations
  MalaCards Gene Search: CD226
Diseases sorted by gene-association score: ovarian cystic teratoma (11), mature teratoma of the ovary (10), refractory celiac disease (7), lymphoproliferative syndrome, x-linked, 1 (6), wegener granulomatosis (2)

-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene           more ... click here to view the complete list

-  RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
  Highest median expression: 35.01 RPKM in Cells - EBV-transformed lymphocytes
Total median expression: 45.85 RPKM

View in GTEx track of Genome Browser    View at GTEx portal     View GTEx Body Map

+  Microarray Expression Data
  Press "+" in the title bar above to open this section.

-  mRNA Secondary Structure of 3' and 5' UTRs
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -75.60253-0.299 Picture PostScript Text
3' UTR -342.201358-0.252 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  InterPro Domains: Graphical view of domain structure
IPR013783 - Ig-like_fold

ModBase Predicted Comparative 3D Structure on J3QR77
The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
No orthologGenome BrowserNo orthologNo orthologNo orthologNo ortholog
Gene Details     
Gene Sorter     
 Protein Sequence    

-  Gene Ontology (GO) Annotations with Structured Vocabulary
  Cellular Component:
GO:0016020 membrane
GO:0016021 integral component of membrane

-  Descriptions from all associated GenBank mRNAs
  GU935335 - Homo sapiens CD226 antigen Delta 12 nt mutant (CD226) mRNA, complete sequence, alternatively spliced.
GU935336 - Homo sapiens CD226 antigen Delta exon 2-3 (CD226) mRNA, complete sequence, alternatively spliced.
U56102 - Human adhesion molecule DNAM-1 mRNA, complete cds.
JD172534 - Sequence 153558 from Patent EP1572962.
JD208260 - Sequence 189284 from Patent EP1572962.
JD224237 - Sequence 205261 from Patent EP1572962.
JD440941 - Sequence 421965 from Patent EP1572962.
JD353256 - Sequence 334280 from Patent EP1572962.
JD493294 - Sequence 474318 from Patent EP1572962.
JD304667 - Sequence 285691 from Patent EP1572962.
JD501876 - Sequence 482900 from Patent EP1572962.
JD181541 - Sequence 162565 from Patent EP1572962.
JD206161 - Sequence 187185 from Patent EP1572962.
JD077171 - Sequence 58195 from Patent EP1572962.
JD077810 - Sequence 58834 from Patent EP1572962.
JD444371 - Sequence 425395 from Patent EP1572962.
JD453181 - Sequence 434205 from Patent EP1572962.
JD131566 - Sequence 112590 from Patent EP1572962.
JD355967 - Sequence 336991 from Patent EP1572962.
JD507687 - Sequence 488711 from Patent EP1572962.
AJ537553 - Homo sapiens mRNA for DNAM-1 protein.
BC074787 - Homo sapiens CD226 molecule, mRNA (cDNA clone MGC:104109 IMAGE:30915562), complete cds.
AK313199 - Homo sapiens cDNA, FLJ93698, highly similar to Homo sapiens CD226 antigen (CD226), mRNA.
KJ898272 - Synthetic construct Homo sapiens clone ccsbBroadEn_07666 CD226 gene, encodes complete protein.
JD205508 - Sequence 186532 from Patent EP1572962.
JD215814 - Sequence 196838 from Patent EP1572962.
JD343129 - Sequence 324153 from Patent EP1572962.
JD445469 - Sequence 426493 from Patent EP1572962.
JD472794 - Sequence 453818 from Patent EP1572962.
JD410994 - Sequence 392018 from Patent EP1572962.
JD461993 - Sequence 443017 from Patent EP1572962.
JD520424 - Sequence 501448 from Patent EP1572962.

-  Biochemical and Signaling Pathways
  KEGG - Kyoto Encyclopedia of Genes and Genomes
hsa04514 - Cell adhesion molecules (CAMs)

-  Other Names for This Gene
  Alternate Gene Symbols: J3QR77, J3QR77_HUMAN, NM_001303619, uc021uli.1, uc021uli.2, uc021uli.3
UCSC ID: uc021uli.3
RefSeq Accession: NM_001303619
Protein: J3QR77 CCDS: CCDS77197.1

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.