Human Gene ADAM10 (ENST00000561288.1) Description and Page Index
  Description: The sequence shown here is derived from an Ensembl automatic analysis pipeline and should be considered as preliminary data. (from UniProt H0YK32)
RefSeq Summary (NM_001320570): Members of the ADAM family are cell surface proteins with a unique structure possessing both potential adhesion and protease domains. This gene encodes and ADAM family member that cleaves many proteins including TNF-alpha and E-cadherin. Alternate splicing results in multiple transcript variants encoding different proteins that may undergo similar processing. [provided by RefSeq, Feb 2016].
Gencode Transcript: ENST00000561288.1
Gencode Gene: ENSG00000137845.15
Transcript (Including UTRs)
   Position: hg38 chr15:58,597,164-58,749,707 Size: 152,544 Total Exon Count: 2 Strand: -
Coding Region
   Position: hg38 chr15:58,597,457-58,749,534 Size: 152,078 Coding Exon Count: 2 

Page IndexSequence and LinksUniProtKB CommentsMalaCardsCTDRNA-Seq Expression
Microarray ExpressionRNA StructureProtein StructureOther SpeciesmRNA DescriptionsPathways
Other NamesMethods
Data last updated: 2019-09-04

-  Sequence and Links to Tools and Databases
Genomic Sequence (chr15:58,597,164-58,749,707)mRNA (may differ from genome)Protein (38 aa)
Gene SorterGenome BrowserOther Species FASTAGene interactionsTable SchemaBioGPS
MGImyGene2PubMedStanford SOURCEUniProtKBWikipedia

-  Comments and Description Text from UniProtKB
DESCRIPTION: SubName: Full=Disintegrin and metalloproteinase domain-containing protein 10;
CAUTION: The sequence shown here is derived from an Ensembl automatic analysis pipeline and should be considered as preliminary data.

-  MalaCards Disease Associations
  MalaCards Gene Search: ADAM10
Diseases sorted by gene-association score: reticulate acropigmentation of kitamura* (1696), alzheimer disease 18* (904), dowling-degos disease* (422), alzheimer disease (16), prion disease (8), scrapie (6)
* = Manually curated disease association

-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene           more ... click here to view the complete list

-  RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
  Highest median expression: 23.07 RPKM in Cells - Transformed fibroblasts
Total median expression: 495.98 RPKM

View in GTEx track of Genome Browser    View at GTEx portal     View GTEx Body Map

+  Microarray Expression Data
  Press "+" in the title bar above to open this section.

-  mRNA Secondary Structure of 3' and 5' UTRs
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -82.60173-0.477 Picture PostScript Text
3' UTR -59.20293-0.202 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  ModBase Predicted Comparative 3D Structure on H0YK32
The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
No orthologNo orthologNo orthologNo orthologNo orthologNo ortholog

-  Descriptions from all associated GenBank mRNAs
  LF384563 - JP 2014500723-A/192066: Polycomb-Associated Non-Coding RNAs.
MA620140 - JP 2018138019-A/192066: Polycomb-Associated Non-Coding RNAs.
BC055087 - Homo sapiens ADAM metallopeptidase domain 10, mRNA (cDNA clone IMAGE:4698521).
BC104659 - Homo sapiens ADAM metallopeptidase domain 10, mRNA (cDNA clone IMAGE:4657963).
AF009615 - Homo sapiens ADAM10 (ADAM10) mRNA, complete cds.
BC143935 - Homo sapiens cDNA clone IMAGE:9052453.
BC126253 - Homo sapiens ADAM metallopeptidase domain 10, mRNA (cDNA clone MGC:161531 IMAGE:8991969), complete cds.
AK300472 - Homo sapiens cDNA FLJ57594 complete cds, highly similar to ADAM 10 precursor (EC (Adisintegrin and metalloproteinase domain 10).
AK023460 - Homo sapiens cDNA FLJ13398 fis, clone PLACE1001377, highly similar to Homo sapiens ADAM10 (ADAM10) mRNA.
Z48579 - H.sapiens mRNA for disintegrin-metalloprotease (partial).
JD234401 - Sequence 215425 from Patent EP1572962.
JD298749 - Sequence 279773 from Patent EP1572962.
JD539542 - Sequence 520566 from Patent EP1572962.
LF377596 - JP 2014500723-A/185099: Polycomb-Associated Non-Coding RNAs.
MA613173 - JP 2018138019-A/185099: Polycomb-Associated Non-Coding RNAs.
JD165758 - Sequence 146782 from Patent EP1572962.
JD474820 - Sequence 455844 from Patent EP1572962.
JD448147 - Sequence 429171 from Patent EP1572962.
LF377556 - JP 2014500723-A/185059: Polycomb-Associated Non-Coding RNAs.
MA613133 - JP 2018138019-A/185059: Polycomb-Associated Non-Coding RNAs.
JD290092 - Sequence 271116 from Patent EP1572962.
JD391229 - Sequence 372253 from Patent EP1572962.
JD053650 - Sequence 34674 from Patent EP1572962.
JD540904 - Sequence 521928 from Patent EP1572962.
JD419798 - Sequence 400822 from Patent EP1572962.
JD409854 - Sequence 390878 from Patent EP1572962.

-  Biochemical and Signaling Pathways
  KEGG - Kyoto Encyclopedia of Genes and Genomes
hsa05010 - Alzheimer's disease
hsa05120 - Epithelial cell signaling in Helicobacter pylori infection

BioCarta from NCI Cancer Genome Anatomy Project
h_appPathway - Generation of amyloid b-peptide by PS1

-  Other Names for This Gene
  Alternate Gene Symbols: AF009615, H0YK32, H0YK32_HUMAN, uc059jrp.1
UCSC ID: uc059jrp.1
RefSeq Accession: NM_001320570
Protein: H0YK32

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.