Human Gene ADAM10 (ENST00000561288.1) Description and Page Index
Description: The sequence shown here is derived from an Ensembl automatic analysis pipeline and should be considered as preliminary data. (from UniProt H0YK32) RefSeq Summary (NM_001320570): Members of the ADAM family are cell surface proteins with a unique structure possessing both potential adhesion and protease domains. This gene encodes and ADAM family member that cleaves many proteins including TNF-alpha and E-cadherin. Alternate splicing results in multiple transcript variants encoding different proteins that may undergo similar processing. [provided by RefSeq, Feb 2016]. Gencode Transcript: ENST00000561288.1 Gencode Gene: ENSG00000137845.15 Transcript (Including UTRs) Position: hg38 chr15:58,597,164-58,749,707 Size: 152,544 Total Exon Count: 2 Strand: - Coding Region Position: hg38 chr15:58,597,457-58,749,534 Size: 152,078 Coding Exon Count: 2
ID:H0YK32_HUMAN DESCRIPTION: SubName: Full=Disintegrin and metalloproteinase domain-containing protein 10; CAUTION: The sequence shown here is derived from an Ensembl automatic analysis pipeline and should be considered as preliminary data.
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
Protein Domain and Structure Information
ModBase Predicted Comparative 3D Structure on H0YK32
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
Descriptions from all associated GenBank mRNAs
LF384563 - JP 2014500723-A/192066: Polycomb-Associated Non-Coding RNAs. MA620140 - JP 2018138019-A/192066: Polycomb-Associated Non-Coding RNAs. BC055087 - Homo sapiens ADAM metallopeptidase domain 10, mRNA (cDNA clone IMAGE:4698521). BC104659 - Homo sapiens ADAM metallopeptidase domain 10, mRNA (cDNA clone IMAGE:4657963). AF009615 - Homo sapiens ADAM10 (ADAM10) mRNA, complete cds. BC143935 - Homo sapiens cDNA clone IMAGE:9052453. BC126253 - Homo sapiens ADAM metallopeptidase domain 10, mRNA (cDNA clone MGC:161531 IMAGE:8991969), complete cds. AK300472 - Homo sapiens cDNA FLJ57594 complete cds, highly similar to ADAM 10 precursor (EC 188.8.131.52) (Adisintegrin and metalloproteinase domain 10). AK023460 - Homo sapiens cDNA FLJ13398 fis, clone PLACE1001377, highly similar to Homo sapiens ADAM10 (ADAM10) mRNA. Z48579 - H.sapiens mRNA for disintegrin-metalloprotease (partial). JD234401 - Sequence 215425 from Patent EP1572962. JD298749 - Sequence 279773 from Patent EP1572962. JD539542 - Sequence 520566 from Patent EP1572962. LF377596 - JP 2014500723-A/185099: Polycomb-Associated Non-Coding RNAs. MA613173 - JP 2018138019-A/185099: Polycomb-Associated Non-Coding RNAs. JD165758 - Sequence 146782 from Patent EP1572962. JD474820 - Sequence 455844 from Patent EP1572962. JD448147 - Sequence 429171 from Patent EP1572962. LF377556 - JP 2014500723-A/185059: Polycomb-Associated Non-Coding RNAs. MA613133 - JP 2018138019-A/185059: Polycomb-Associated Non-Coding RNAs. JD290092 - Sequence 271116 from Patent EP1572962. JD391229 - Sequence 372253 from Patent EP1572962. JD053650 - Sequence 34674 from Patent EP1572962. JD540904 - Sequence 521928 from Patent EP1572962. JD419798 - Sequence 400822 from Patent EP1572962. JD409854 - Sequence 390878 from Patent EP1572962.
Biochemical and Signaling Pathways
KEGG - Kyoto Encyclopedia of Genes and Genomes hsa05010 - Alzheimer's disease hsa05120 - Epithelial cell signaling in Helicobacter pylori infection
BioCarta from NCI Cancer Genome Anatomy Project h_appPathway - Generation of amyloid b-peptide by PS1