Human Gene PNN (ENST00000556530.1) Description and Page Index
  Description: The sequence shown here is derived from an Ensembl automatic analysis pipeline and should be considered as preliminary data. (from UniProt G3V5F0)
Gencode Transcript: ENST00000556530.1
Gencode Gene: ENSG00000100941.9
Transcript (Including UTRs)
   Position: hg38 chr14:39,175,230-39,177,708 Size: 2,479 Total Exon Count: 4 Strand: +
Coding Region
   Position: hg38 chr14:39,175,280-39,177,511 Size: 2,232 Coding Exon Count: 4 

Page IndexSequence and LinksUniProtKB CommentsMalaCardsCTDRNA-Seq Expression
Microarray ExpressionRNA StructureProtein StructureOther SpeciesmRNA DescriptionsOther Names
Methods
Data last updated: 2019-09-04

-  Sequence and Links to Tools and Databases
 
Genomic Sequence (chr14:39,175,230-39,177,708)mRNA (may differ from genome)Protein (117 aa)
Gene SorterGenome BrowserOther Species FASTAGene interactionsTable SchemaBioGPS
CGAPEnsemblExonPrimerGeneCardsHGNCLynx
MGIPubMedStanford SOURCEUniProtKBWikipedia

-  Comments and Description Text from UniProtKB
  ID: G3V5F0_HUMAN
DESCRIPTION: SubName: Full=Pinin;
CAUTION: The sequence shown here is derived from an Ensembl automatic analysis pipeline and should be considered as preliminary data.

-  MalaCards Disease Associations
  MalaCards Gene Search: PNN
Diseases sorted by gene-association score: melanoma metastasis (7), premenstrual tension (2), epileptic encephalopathy, childhood-onset (1)

-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene
  • D013749 Tetrachlorodibenzodioxin
  • D001564 Benzo(a)pyrene
  • C049325 1,2-dithiol-3-thione
  • C532162 2-(1H-indazol-4-yl)-6-(4-methanesulfonylpiperazin-1-ylmethyl)-4-morpholin-4-ylthieno(3,2-d)pyrimidine
  • C030370 2-methoxy-5-(2',3',4'-trimethoxyphenyl)tropone
  • C518576 2-methylbutyric acid 4-((1,3)dioxan-5-ylmethoxyimino)-8-(2-(4-hydroxy-6-oxo-tetrahydropyran-2-yl)ethyl -7-methyl-6-oxo-1,2,3,4,6,7,8,8a-octahydronaphthyl)heptanoate
  • D015123 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide
  • D000082 Acetaminophen
  • D016604 Aflatoxin B1
  • D002737 Chloroprene
          more ... click here to view the complete list

-  RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
  Highest median expression: 86.51 RPKM in Cells - EBV-transformed lymphocytes
Total median expression: 2536.90 RPKM



View in GTEx track of Genome Browser    View at GTEx portal     View GTEx Body Map

+  Microarray Expression Data
  Press "+" in the title bar above to open this section.

-  mRNA Secondary Structure of 3' and 5' UTRs
 
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -13.3050-0.266 Picture PostScript Text
3' UTR -42.90197-0.218 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  InterPro Domains: Graphical view of domain structure
IPR006787 - Pinin_SDK_N

Pfam Domains:
PF04697 - pinin/SDK conserved region

ModBase Predicted Comparative 3D Structure on G3V5F0
FrontTopSide
The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
Genome BrowserGenome BrowserNo orthologNo orthologNo orthologNo ortholog
Gene Details     
Gene Sorter     
MGIRGD    
Protein SequenceProtein Sequence    
AlignmentAlignment    

-  Descriptions from all associated GenBank mRNAs
  AK292579 - Homo sapiens cDNA FLJ75071 complete cds, highly similar to Homo sapiens pinin, desmosome associated protein (PNN), mRNA.
AF112222 - UNVERIFIED: Homo sapiens nuclear protein SDK3 mRNA, complete cds.
AK223612 - Homo sapiens mRNA for pinin, desmosome associated protein variant, clone: FCC133C12.
U77718 - Human desmosome associated protein pinin mRNA, complete cds.
BC062602 - Homo sapiens pinin, desmosome associated protein, mRNA (cDNA clone MGC:70809 IMAGE:5491466), complete cds.
KJ897351 - Synthetic construct Homo sapiens clone ccsbBroadEn_06745 PNN gene, encodes complete protein.
Y09703 - H.sapiens mRNA for MEMA protein.
Y10351 - H.sapiens mRNA for nuclear protein SDK3, partial.
AK303136 - Homo sapiens cDNA FLJ56911 complete cds, highly similar to Pinin.

-  Other Names for This Gene
  Alternate Gene Symbols: AF112222, G3V5F0, G3V5F0_HUMAN, uc059bam.1
UCSC ID: uc059bam.1
RefSeq Accession: NM_002687
Protein: G3V5F0

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.