Human Gene DMAC2L (ENST00000554204.6) Description and Page Index
  Description: The sequence shown here is derived from an Ensembl automatic analysis pipeline and should be considered as preliminary data. (from UniProt G3V446)
RefSeq Summary (NM_001003803): This gene encodes a subunit of mitochondrial ATP synthase. Mitochondrial ATP synthase catalyzes ATP synthesis, utilizing an electrochemical gradient of protons across the inner membrane during oxidative phosphorylation. ATP synthase is composed of two linked multi-subunit complexes: the soluble catalytic core, F1, and the membrane-spanning component, Fo, comprising the proton channel. This gene encodes the subunit s, also known as factor B, of the proton channel. This subunit is necessary for the energy transduction activity of the ATP synthase complexes. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Jul 2008].
Gencode Transcript: ENST00000554204.6
Gencode Gene: ENSG00000125375.15
Transcript (Including UTRs)
   Position: hg38 chr14:50,312,329-50,326,226 Size: 13,898 Total Exon Count: 5 Strand: +
Coding Region
   Position: hg38 chr14:50,313,021-50,325,723 Size: 12,703 Coding Exon Count: 5 

Page IndexSequence and LinksUniProtKB CommentsRNA-Seq ExpressionMicroarray ExpressionRNA Structure
Protein StructureOther SpeciesmRNA DescriptionsOther NamesMethods
Data last updated: 2019-09-04

-  Sequence and Links to Tools and Databases
 
Genomic Sequence (chr14:50,312,329-50,326,226)mRNA (may differ from genome)Protein (215 aa)
Gene SorterGenome BrowserOther Species FASTATable SchemaBioGPSEnsembl
ExonPrimerGeneCardsMGIPubMedStanford SOURCEUniProtKB
Wikipedia

-  Comments and Description Text from UniProtKB
  ID: G3V446_HUMAN
DESCRIPTION: SubName: Full=ATP synthase subunit s, mitochondrial;
CAUTION: The sequence shown here is derived from an Ensembl automatic analysis pipeline and should be considered as preliminary data.

-  RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
  Highest median expression: 15.21 RPKM in Testis
Total median expression: 196.69 RPKM



View in GTEx track of Genome Browser    View at GTEx portal     View GTEx Body Map

+  Microarray Expression Data
  Press "+" in the title bar above to open this section.

-  mRNA Secondary Structure of 3' and 5' UTRs
 
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -279.70692-0.404 Picture PostScript Text
3' UTR -133.30503-0.265 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  ModBase Predicted Comparative 3D Structure on G3V446
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The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
Genome BrowserGenome BrowserNo orthologNo orthologNo orthologNo ortholog
Gene Details     
Gene Sorter     
MGIRGDEnsembl   
Protein SequenceProtein Sequence    
AlignmentAlignment    

-  Descriptions from all associated GenBank mRNAs
  AF390029 - Homo sapiens ATP synthase coupling factor B-like 1 mRNA, complete cds; nuclear gene for mitochondrial product.
BC011549 - Homo sapiens ATP synthase, H+ transporting, mitochondrial F0 complex, subunit s (factor B), mRNA (cDNA clone MGC:19945 IMAGE:4554461), complete cds.
JD173500 - Sequence 154524 from Patent EP1572962.
AF052186 - Homo sapiens clone 24431 mRNA sequence.
U79253 - Human clone 23893 mRNA, complete cds.
JD467238 - Sequence 448262 from Patent EP1572962.
JD459326 - Sequence 440350 from Patent EP1572962.
BC087851 - Homo sapiens ATP synthase, H+ transporting, mitochondrial F0 complex, subunit s (factor B), mRNA (cDNA clone IMAGE:30399343).
JD124746 - Sequence 105770 from Patent EP1572962.
JD128753 - Sequence 109777 from Patent EP1572962.
JD405737 - Sequence 386761 from Patent EP1572962.
AK290008 - Homo sapiens cDNA FLJ77027 complete cds, highly similar to Homo sapiens mitochondrial ATP synthase regulatory component factor B (ATPW) mRNA.
JD139909 - Sequence 120933 from Patent EP1572962.
JD149838 - Sequence 130862 from Patent EP1572962.
JD059194 - Sequence 40218 from Patent EP1572962.
JD526547 - Sequence 507571 from Patent EP1572962.
AY052377 - Homo sapiens mitochondrial ATP synthase regulatory component factor B (ATPW) mRNA, complete cds; nuclear gene for mitochondrial product.
JD040859 - Sequence 21883 from Patent EP1572962.
JD552637 - Sequence 533661 from Patent EP1572962.
CU679952 - Synthetic construct Homo sapiens gateway clone IMAGE:100018526 5' read ATP5S mRNA.
KJ898661 - Synthetic construct Homo sapiens clone ccsbBroadEn_08055 ATP5S gene, encodes complete protein.
DQ572161 - Homo sapiens piRNA piR-40273, complete sequence.
JD144716 - Sequence 125740 from Patent EP1572962.

-  Other Names for This Gene
  Alternate Gene Symbols: ATP5S, BC011549, G3V446, G3V446_HUMAN, uc059bir.1, uc059bir.2
UCSC ID: uc059bir.2
RefSeq Accession: NM_001003803
Protein: G3V446 CCDS: CCDS32075.1

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.