Human Gene FBXO33 (ENST00000554190.1) Description and Page Index
  Description: The sequence shown here is derived from an Ensembl automatic analysis pipeline and should be considered as preliminary data. (from UniProt G3V3J7)
RefSeq Summary (NM_203301): This locus represents an member of the F-box gene family. The encoded protein contains an F-box motif and a domain that might form a structure similar to a leucine-rich repeat found in placental RNAse inhibitor. This locus may be associated with copy number variation of UGT2B17 (GeneID 7367), which has been associated with susceptibility to osteoporosis.[provided by RefSeq, Sep 2010]. Sequence Note: This RefSeq record was created from transcript and genomic sequence data to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments. ##Evidence-Data-START## Transcript exon combination :: BC053537.1, SRR1803617.83451.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA2148874, SAMEA2467147 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## RefSeq Select criteria :: based on single protein-coding transcript ##RefSeq-Attributes-END##
Gencode Transcript: ENST00000554190.1
Gencode Gene: ENSG00000165355.7
Transcript (Including UTRs)
   Position: hg38 chr14:39,399,566-39,431,875 Size: 32,310 Total Exon Count: 2 Strand: -
Coding Region
   Position: hg38 chr14:39,399,733-39,431,778 Size: 32,046 Coding Exon Count: 2 

Page IndexSequence and LinksUniProtKB CommentsMalaCardsCTDRNA-Seq Expression
RNA StructureProtein StructureOther SpeciesmRNA DescriptionsOther NamesMethods
Data last updated: 2019-09-04

-  Sequence and Links to Tools and Databases
 
Genomic Sequence (chr14:39,399,566-39,431,875)mRNA (may differ from genome)Protein (89 aa)
Gene SorterGenome BrowserOther Species FASTAGene interactionsTable SchemaBioGPS
CGAPEnsemblExonPrimerGeneCardsHGNCLynx
MGIPubMedStanford SOURCEUniProtKB

-  Comments and Description Text from UniProtKB
  ID: G3V3J7_HUMAN
DESCRIPTION: SubName: Full=F-box only protein 33;
CAUTION: The sequence shown here is derived from an Ensembl automatic analysis pipeline and should be considered as preliminary data.

-  MalaCards Disease Associations
  MalaCards Gene Search: FBXO33
Diseases sorted by gene-association score: attention deficit-hyperactivity disorder (1)

-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene           more ... click here to view the complete list

-  RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
  Highest median expression: 11.35 RPKM in Cells - EBV-transformed lymphocytes
Total median expression: 232.48 RPKM



View in GTEx track of Genome Browser    View at GTEx portal     View GTEx Body Map

-  mRNA Secondary Structure of 3' and 5' UTRs
 
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -37.9097-0.391 Picture PostScript Text
3' UTR -46.30167-0.277 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  ModBase Predicted Comparative 3D Structure on G3V3J7
FrontTopSide
The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
Genome BrowserGenome BrowserNo orthologNo orthologNo orthologNo ortholog
Gene Details     
Gene Sorter     
MGIRGD    
Protein SequenceProtein Sequence    
AlignmentAlignment    

-  Descriptions from all associated GenBank mRNAs
  LF384852 - JP 2014500723-A/192355: Polycomb-Associated Non-Coding RNAs.
MA620429 - JP 2018138019-A/192355: Polycomb-Associated Non-Coding RNAs.
BC053537 - Homo sapiens F-box protein 33, mRNA (cDNA clone MGC:61678 IMAGE:5181903), complete cds.
BC042535 - Homo sapiens F-box protein 33, mRNA (cDNA clone IMAGE:4751694), partial cds.
BC030611 - Homo sapiens cDNA clone IMAGE:4827474, containing frame-shift errors.
BC068566 - Homo sapiens F-box protein 33, mRNA (cDNA clone MGC:87518 IMAGE:5270962), complete cds.
AK294140 - Homo sapiens cDNA FLJ50090 complete cds, highly similar to F-box only protein 33.
BX248772 - human full-length cDNA 5-PRIME end of clone CS0DI052YH07 of Placenta of Homo sapiens (human).

-  Other Names for This Gene
  Alternate Gene Symbols: BC068566, G3V3J7, G3V3J7_HUMAN, uc059bbb.1
UCSC ID: uc059bbb.1
RefSeq Accession: NM_203301
Protein: G3V3J7

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.