Human Gene LRFN5 (ENST00000554120.5) Description and Page Index
  Description: Contains 1 LRRCT domain. (from UniProt G3V4N1)
RefSeq Summary (NM_001330106): This gene encodes a protein that belongs to the leucine-rich repeat and fibronectin type III domain-containing family of proteins. A similar protein in mouse, a glycosylated transmembrane protein, is thought to function in presynaptic differentiation. [provided by RefSeq, Sep 2016].
Gencode Transcript: ENST00000554120.5
Gencode Gene: ENSG00000165379.13
Transcript (Including UTRs)
   Position: hg38 chr14:41,608,415-41,904,549 Size: 296,135 Total Exon Count: 4 Strand: +
Coding Region
   Position: hg38 chr14:41,886,626-41,904,170 Size: 17,545 Coding Exon Count: 2 

Page IndexSequence and LinksUniProtKB CommentsCTDRNA-Seq ExpressionRNA Structure
Protein StructureOther SpeciesmRNA DescriptionsOther NamesMethods
Data last updated: 2019-09-04

-  Sequence and Links to Tools and Databases
 
Genomic Sequence (chr14:41,608,415-41,904,549)mRNA (may differ from genome)Protein (465 aa)
Gene SorterGenome BrowserOther Species FASTATable SchemaBioGPSCGAP
EnsemblExonPrimerGeneCardsHGNCLynxMGI
PubMedStanford SOURCEUniProtKB

-  Comments and Description Text from UniProtKB
  ID: G3V4N1_HUMAN
DESCRIPTION: SubName: Full=Leucine-rich repeat and fibronectin type-III domain-containing protein 5;
SIMILARITY: Contains 1 LRRCT domain.
SIMILARITY: Contains 1 LRRNT domain.
CAUTION: The sequence shown here is derived from an Ensembl automatic analysis pipeline and should be considered as preliminary data.

-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene

-  RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
  Highest median expression: 5.89 RPKM in Brain - Frontal Cortex (BA9)
Total median expression: 55.74 RPKM



View in GTEx track of Genome Browser    View at GTEx portal     View GTEx Body Map

-  mRNA Secondary Structure of 3' and 5' UTRs
 
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -106.20344-0.309 Picture PostScript Text
3' UTR -66.10379-0.174 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  InterPro Domains: Graphical view of domain structure
IPR000483 - Cys-rich_flank_reg_C
IPR007110 - Ig-like
IPR013783 - Ig-like_fold
IPR013098 - Ig_I-set
IPR003598 - Ig_sub2
IPR001611 - Leu-rich_rpt
IPR003591 - Leu-rich_rpt_typical-subtyp
IPR000372 - LRR-contain_N

Pfam Domains:
PF07679 - Immunoglobulin I-set domain

ModBase Predicted Comparative 3D Structure on G3V4N1
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-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
Genome BrowserGenome BrowserNo orthologNo orthologNo orthologNo ortholog
Gene Details     
Gene Sorter     
MGIRGD    
Protein SequenceProtein Sequence    
AlignmentAlignment    

-  Descriptions from all associated GenBank mRNAs
  AK096627 - Homo sapiens cDNA FLJ39308 fis, clone OCBBF2013285, highly similar to Leucine-rich repeat and fibronectin type-III domain-containing protein 5 precursor.
BC043165 - Homo sapiens leucine rich repeat and fibronectin type III domain containing 5, mRNA (cDNA clone MGC:44144 IMAGE:5286818), complete cds.
AK055365 - Homo sapiens cDNA FLJ30803 fis, clone FEBRA2001245, weakly similar to NAG14.
AK299632 - Homo sapiens cDNA FLJ56792 complete cds, highly similar to Leucine-rich repeat and fibronectin type-III domain-containing protein 5 precursor.
AL832129 - Homo sapiens mRNA; cDNA DKFZp686G0210 (from clone DKFZp686G0210).
JD263547 - Sequence 244571 from Patent EP1572962.
JD419038 - Sequence 400062 from Patent EP1572962.
JD168174 - Sequence 149198 from Patent EP1572962.
JD167506 - Sequence 148530 from Patent EP1572962.
JD104933 - Sequence 85957 from Patent EP1572962.
CU692142 - Synthetic construct Homo sapiens gateway clone IMAGE:100020979 5' read LRFN5 mRNA.
JF432391 - Synthetic construct Homo sapiens clone IMAGE:100073593 leucine rich repeat and fibronectin type III domain containing 5 (LRFN5) gene, encodes complete protein.

-  Other Names for This Gene
  Alternate Gene Symbols: BC043165, G3V4N1, G3V4N1_HUMAN, uc059bbo.1
UCSC ID: uc059bbo.1
RefSeq Accession: NM_001330106
Protein: G3V4N1 CCDS: CCDS81800.1

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.