Human Gene LRFN5 (ENST00000554120.5) Description and Page Index
  Description: Contains 1 LRRCT domain. (from UniProt G3V4N1)
RefSeq Summary (NM_001330106): This gene encodes a protein that belongs to the leucine-rich repeat and fibronectin type III domain-containing family of proteins. A similar protein in mouse, a glycosylated transmembrane protein, is thought to function in presynaptic differentiation. [provided by RefSeq, Sep 2016].
Gencode Transcript: ENST00000554120.5
Gencode Gene: ENSG00000165379.13
Transcript (Including UTRs)
   Position: hg38 chr14:41,608,415-41,904,549 Size: 296,135 Total Exon Count: 4 Strand: +
Coding Region
   Position: hg38 chr14:41,886,626-41,904,170 Size: 17,545 Coding Exon Count: 2 

Page IndexSequence and LinksUniProtKB CommentsCTDRNA-Seq ExpressionRNA Structure
Protein StructureOther SpeciesmRNA DescriptionsOther NamesMethods
Data last updated: 2019-09-04

-  Sequence and Links to Tools and Databases
Genomic Sequence (chr14:41,608,415-41,904,549)mRNA (may differ from genome)Protein (465 aa)
Gene SorterGenome BrowserOther Species FASTATable SchemaBioGPSCGAP
PubMedStanford SOURCEUniProtKB

-  Comments and Description Text from UniProtKB
DESCRIPTION: SubName: Full=Leucine-rich repeat and fibronectin type-III domain-containing protein 5;
SIMILARITY: Contains 1 LRRCT domain.
SIMILARITY: Contains 1 LRRNT domain.
CAUTION: The sequence shown here is derived from an Ensembl automatic analysis pipeline and should be considered as preliminary data.

-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene

-  RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
  Highest median expression: 5.89 RPKM in Brain - Frontal Cortex (BA9)
Total median expression: 55.74 RPKM

View in GTEx track of Genome Browser    View at GTEx portal     View GTEx Body Map

-  mRNA Secondary Structure of 3' and 5' UTRs
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -106.20344-0.309 Picture PostScript Text
3' UTR -66.10379-0.174 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  InterPro Domains: Graphical view of domain structure
IPR000483 - Cys-rich_flank_reg_C
IPR007110 - Ig-like
IPR013783 - Ig-like_fold
IPR013098 - Ig_I-set
IPR003598 - Ig_sub2
IPR001611 - Leu-rich_rpt
IPR003591 - Leu-rich_rpt_typical-subtyp
IPR000372 - LRR-contain_N

Pfam Domains:
PF07679 - Immunoglobulin I-set domain

ModBase Predicted Comparative 3D Structure on G3V4N1
The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
Genome BrowserGenome BrowserNo orthologNo orthologNo orthologNo ortholog
Gene Details     
Gene Sorter     
Protein SequenceProtein Sequence    

-  Descriptions from all associated GenBank mRNAs
  AK096627 - Homo sapiens cDNA FLJ39308 fis, clone OCBBF2013285, highly similar to Leucine-rich repeat and fibronectin type-III domain-containing protein 5 precursor.
BC043165 - Homo sapiens leucine rich repeat and fibronectin type III domain containing 5, mRNA (cDNA clone MGC:44144 IMAGE:5286818), complete cds.
AK055365 - Homo sapiens cDNA FLJ30803 fis, clone FEBRA2001245, weakly similar to NAG14.
AK299632 - Homo sapiens cDNA FLJ56792 complete cds, highly similar to Leucine-rich repeat and fibronectin type-III domain-containing protein 5 precursor.
AL832129 - Homo sapiens mRNA; cDNA DKFZp686G0210 (from clone DKFZp686G0210).
JD263547 - Sequence 244571 from Patent EP1572962.
JD419038 - Sequence 400062 from Patent EP1572962.
JD168174 - Sequence 149198 from Patent EP1572962.
JD167506 - Sequence 148530 from Patent EP1572962.
JD104933 - Sequence 85957 from Patent EP1572962.
CU692142 - Synthetic construct Homo sapiens gateway clone IMAGE:100020979 5' read LRFN5 mRNA.
JF432391 - Synthetic construct Homo sapiens clone IMAGE:100073593 leucine rich repeat and fibronectin type III domain containing 5 (LRFN5) gene, encodes complete protein.

-  Other Names for This Gene
  Alternate Gene Symbols: BC043165, G3V4N1, G3V4N1_HUMAN, uc059bbo.1
UCSC ID: uc059bbo.1
RefSeq Accession: NM_001330106
Protein: G3V4N1 CCDS: CCDS81800.1

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.