Human Gene NOMO2 (ENST00000543392.5) Description and Page Index
  Description: May antagonize Nodal signaling and subsequent organization of axial structures during mesodermal patterning, via its interaction with NCLN (By similarity). (from UniProt Q5JPE7)
RefSeq Summary (NM_001004060): This gene encodes a protein originally thought to be related to the collagenase gene family. This gene is one of three highly similar genes in a region of duplication located on the p arm of chromosome 16. These three genes encode closely related proteins that may have the same function. The protein encoded by one of these genes has been identified as part of a protein complex that participates in the Nodal signaling pathway during vertebrate development. Mutations in ABCC6, which is located nearby, rather than mutations in this gene are associated with pseudoxanthoma elasticum (PXE). Two transcripts encoding different isoforms have been described. [provided by RefSeq, Jul 2008].
Gencode Transcript: ENST00000543392.5
Gencode Gene: ENSG00000185164.14
Transcript (Including UTRs)
   Position: hg38 chr16:18,499,936-18,562,074 Size: 62,139 Total Exon Count: 31 Strand: -
Coding Region
   Position: hg38 chr16:18,499,970-18,551,446 Size: 51,477 Coding Exon Count: 28 

Page IndexSequence and LinksUniProtKB CommentsMalaCardsCTDRNA-Seq Expression
Microarray ExpressionRNA StructureProtein StructureOther SpeciesGO AnnotationsmRNA Descriptions
Other NamesMethods
Data last updated: 2019-09-04

-  Sequence and Links to Tools and Databases
 
Genomic Sequence (chr16:18,499,936-18,562,074)mRNA (may differ from genome)Protein (1100 aa)
Gene SorterGenome BrowserOther Species FASTAGene interactionsTable SchemaBioGPS
CGAPEnsemblExonPrimerGeneCardsHGNCLynx
MGIneXtProtPubMedReactomeStanford SOURCEUniProtKB

-  Comments and Description Text from UniProtKB
  ID: NOMO2_HUMAN
DESCRIPTION: RecName: Full=Nodal modulator 2; AltName: Full=pM5 protein 2; Flags: Precursor;
FUNCTION: May antagonize Nodal signaling and subsequent organization of axial structures during mesodermal patterning, via its interaction with NCLN (By similarity).
SUBUNIT: Forms a complex with NCLN and TMEM147, resulting in a stabilization of the 3 proteins, which are otherwise quickly degraded by the proteasome.
SUBCELLULAR LOCATION: Endoplasmic reticulum membrane; Single-pass membrane protein.
TISSUE SPECIFICITY: Highly expressed in pancreas and skeletal muscle and, at lower levels, in heart.
CAUTION: There are 3 copies of the NOMO gene on chromosome 16p12- p13: NOMO1 (AC Q15155), NOMO2 and NOMO3 (AC P69849). All 3 are extremely similar, which makes their individual characterization difficult. Thus, most experiments probably do not discriminate between the different members. The results reported in other entries may therefore apply for this protein.

-  MalaCards Disease Associations
  MalaCards Gene Search: NOMO2
Diseases sorted by gene-association score: pseudoxanthoma elasticum (4), superficial urinary bladder cancer (2)

-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene

-  RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
  Highest median expression: 7.11 RPKM in Cells - Transformed fibroblasts
Total median expression: 140.26 RPKM



View in GTEx track of Genome Browser    View at GTEx portal     View GTEx Body Map

+  Microarray Expression Data
  Press "+" in the title bar above to open this section.

-  mRNA Secondary Structure of 3' and 5' UTRs
 
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -175.30428-0.410 Picture PostScript Text
3' UTR -1.6034-0.047 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  InterPro Domains: Graphical view of domain structure
IPR013784 - Carb-bd-like_fold
IPR008969 - CarboxyPept-like_regulatory
IPR014766 - CarboxyPept_regulatory_dom
IPR013783 - Ig-like_fold

ModBase Predicted Comparative 3D Structure on Q5JPE7
FrontTopSide
The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
Genome BrowserGenome BrowserNo orthologNo orthologNo orthologNo ortholog
Gene Details     
Gene Sorter     
MGIRGD    
Protein SequenceProtein Sequence    
AlignmentAlignment    

-  Gene Ontology (GO) Annotations with Structured Vocabulary
  Molecular Function:
GO:0005515 protein binding
GO:0030246 carbohydrate binding

Cellular Component:
GO:0005783 endoplasmic reticulum
GO:0005789 endoplasmic reticulum membrane
GO:0016020 membrane
GO:0016021 integral component of membrane
GO:0032991 macromolecular complex


-  Descriptions from all associated GenBank mRNAs
  LF384271 - JP 2014500723-A/191774: Polycomb-Associated Non-Coding RNAs.
MA619848 - JP 2018138019-A/191774: Polycomb-Associated Non-Coding RNAs.
BC006531 - Homo sapiens NODAL modulator 3, mRNA (cDNA clone IMAGE:3841946), partial cds.
BC041131 - Homo sapiens NODAL modulator 2, mRNA (cDNA clone MGC:47607 IMAGE:5757234), complete cds.
AK027144 - Homo sapiens cDNA: FLJ23491 fis, clone LNG00825, highly similar to HSPM5 Human mRNA for pM5 protein.
BC013837 - Homo sapiens NODAL modulator 3, mRNA (cDNA clone IMAGE:4154260).
AL832855 - Homo sapiens mRNA; cDNA DKFZp667N0525 (from clone DKFZp667N0525).
BC028389 - Homo sapiens NODAL modulator 2, mRNA (cDNA clone MGC:33249 IMAGE:4824724), complete cds.
LF367972 - JP 2014500723-A/175475: Polycomb-Associated Non-Coding RNAs.
MA603549 - JP 2018138019-A/175475: Polycomb-Associated Non-Coding RNAs.
JD207815 - Sequence 188839 from Patent EP1572962.
JD485962 - Sequence 466986 from Patent EP1572962.
AK225803 - Homo sapiens mRNA for nodal modulator 2 isoform 2 variant, clone: FCC130D11.
BC156526 - Synthetic construct Homo sapiens clone IMAGE:100063136, MGC:190703 NODAL modulator 3 (NOMO3) mRNA, encodes complete protein.
KJ904286 - Synthetic construct Homo sapiens clone ccsbBroadEn_13680 NOMO3 gene, encodes complete protein.
LF367970 - JP 2014500723-A/175473: Polycomb-Associated Non-Coding RNAs.
MA603547 - JP 2018138019-A/175473: Polycomb-Associated Non-Coding RNAs.
AB463143 - Synthetic construct DNA, clone: pF1KB1226, Homo sapiens NOMO2 gene for NODAL modulator 2, without stop codon, in Flexi system.
LF367968 - JP 2014500723-A/175471: Polycomb-Associated Non-Coding RNAs.
MA603545 - JP 2018138019-A/175471: Polycomb-Associated Non-Coding RNAs.
LF367967 - JP 2014500723-A/175470: Polycomb-Associated Non-Coding RNAs.
MA603544 - JP 2018138019-A/175470: Polycomb-Associated Non-Coding RNAs.
LF367966 - JP 2014500723-A/175469: Polycomb-Associated Non-Coding RNAs.
MA603543 - JP 2018138019-A/175469: Polycomb-Associated Non-Coding RNAs.
LF367965 - JP 2014500723-A/175468: Polycomb-Associated Non-Coding RNAs.
MA603542 - JP 2018138019-A/175468: Polycomb-Associated Non-Coding RNAs.
LF367964 - JP 2014500723-A/175467: Polycomb-Associated Non-Coding RNAs.
MA603541 - JP 2018138019-A/175467: Polycomb-Associated Non-Coding RNAs.
LF367963 - JP 2014500723-A/175466: Polycomb-Associated Non-Coding RNAs.
MA603540 - JP 2018138019-A/175466: Polycomb-Associated Non-Coding RNAs.
LF367961 - JP 2014500723-A/175464: Polycomb-Associated Non-Coding RNAs.
MA603538 - JP 2018138019-A/175464: Polycomb-Associated Non-Coding RNAs.
LF367960 - JP 2014500723-A/175463: Polycomb-Associated Non-Coding RNAs.
MA603537 - JP 2018138019-A/175463: Polycomb-Associated Non-Coding RNAs.
LF367959 - JP 2014500723-A/175462: Polycomb-Associated Non-Coding RNAs.
MA603536 - JP 2018138019-A/175462: Polycomb-Associated Non-Coding RNAs.
LF367957 - JP 2014500723-A/175460: Polycomb-Associated Non-Coding RNAs.
MA603534 - JP 2018138019-A/175460: Polycomb-Associated Non-Coding RNAs.
LF367956 - JP 2014500723-A/175459: Polycomb-Associated Non-Coding RNAs.
MA603533 - JP 2018138019-A/175459: Polycomb-Associated Non-Coding RNAs.
LF367955 - JP 2014500723-A/175458: Polycomb-Associated Non-Coding RNAs.
MA603532 - JP 2018138019-A/175458: Polycomb-Associated Non-Coding RNAs.
LF367954 - JP 2014500723-A/175457: Polycomb-Associated Non-Coding RNAs.
MA603531 - JP 2018138019-A/175457: Polycomb-Associated Non-Coding RNAs.
LF367952 - JP 2014500723-A/175455: Polycomb-Associated Non-Coding RNAs.
MA603529 - JP 2018138019-A/175455: Polycomb-Associated Non-Coding RNAs.
LF367951 - JP 2014500723-A/175454: Polycomb-Associated Non-Coding RNAs.
MA603528 - JP 2018138019-A/175454: Polycomb-Associated Non-Coding RNAs.
LF367950 - JP 2014500723-A/175453: Polycomb-Associated Non-Coding RNAs.
MA603527 - JP 2018138019-A/175453: Polycomb-Associated Non-Coding RNAs.
LF367949 - JP 2014500723-A/175452: Polycomb-Associated Non-Coding RNAs.
MA603526 - JP 2018138019-A/175452: Polycomb-Associated Non-Coding RNAs.
LF367948 - JP 2014500723-A/175451: Polycomb-Associated Non-Coding RNAs.
MA603525 - JP 2018138019-A/175451: Polycomb-Associated Non-Coding RNAs.
LF367946 - JP 2014500723-A/175449: Polycomb-Associated Non-Coding RNAs.
MA603523 - JP 2018138019-A/175449: Polycomb-Associated Non-Coding RNAs.
LF367945 - JP 2014500723-A/175448: Polycomb-Associated Non-Coding RNAs.
MA603522 - JP 2018138019-A/175448: Polycomb-Associated Non-Coding RNAs.
LF367943 - JP 2014500723-A/175446: Polycomb-Associated Non-Coding RNAs.
MA603520 - JP 2018138019-A/175446: Polycomb-Associated Non-Coding RNAs.
LF367942 - JP 2014500723-A/175445: Polycomb-Associated Non-Coding RNAs.
MA603519 - JP 2018138019-A/175445: Polycomb-Associated Non-Coding RNAs.
LF367940 - JP 2014500723-A/175443: Polycomb-Associated Non-Coding RNAs.
MA603517 - JP 2018138019-A/175443: Polycomb-Associated Non-Coding RNAs.
LF367932 - JP 2014500723-A/175435: Polycomb-Associated Non-Coding RNAs.
MA603509 - JP 2018138019-A/175435: Polycomb-Associated Non-Coding RNAs.

-  Other Names for This Gene
  Alternate Gene Symbols: BC028389, NOMO2_HUMAN, Q5JPE7, uc032dtl.1, uc032dtl.2
UCSC ID: uc032dtl.2
RefSeq Accession: NM_001004060
Protein: Q5JPE7 (aka NOMO2_HUMAN)

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.