Human Gene NOMO2 (ENST00000543392.5) Description and Page Index
Description: May antagonize Nodal signaling and subsequent organization of axial structures during mesodermal patterning, via its interaction with NCLN (By similarity). (from UniProt Q5JPE7) RefSeq Summary (NM_001004060): This gene encodes a protein originally thought to be related to the collagenase gene family. This gene is one of three highly similar genes in a region of duplication located on the p arm of chromosome 16. These three genes encode closely related proteins that may have the same function. The protein encoded by one of these genes has been identified as part of a protein complex that participates in the Nodal signaling pathway during vertebrate development. Mutations in ABCC6, which is located nearby, rather than mutations in this gene are associated with pseudoxanthoma elasticum (PXE). Two transcripts encoding different isoforms have been described. [provided by RefSeq, Jul 2008]. Gencode Transcript: ENST00000543392.5 Gencode Gene: ENSG00000185164.14 Transcript (Including UTRs) Position: hg38 chr16:18,499,936-18,562,074 Size: 62,139 Total Exon Count: 31 Strand: - Coding Region Position: hg38 chr16:18,499,970-18,551,446 Size: 51,477 Coding Exon Count: 28
ID:NOMO2_HUMAN DESCRIPTION: RecName: Full=Nodal modulator 2; AltName: Full=pM5 protein 2; Flags: Precursor; FUNCTION: May antagonize Nodal signaling and subsequent organization of axial structures during mesodermal patterning, via its interaction with NCLN (By similarity). SUBUNIT: Forms a complex with NCLN and TMEM147, resulting in a stabilization of the 3 proteins, which are otherwise quickly degraded by the proteasome. SUBCELLULAR LOCATION: Endoplasmic reticulum membrane; Single-pass membrane protein. TISSUE SPECIFICITY: Highly expressed in pancreas and skeletal muscle and, at lower levels, in heart. CAUTION: There are 3 copies of the NOMO gene on chromosome 16p12- p13: NOMO1 (AC Q15155), NOMO2 and NOMO3 (AC P69849). All 3 are extremely similar, which makes their individual characterization difficult. Thus, most experiments probably do not discriminate between the different members. The results reported in other entries may therefore apply for this protein.
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on Q5JPE7
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.