Human Gene AAGAB (ENST00000542650.5) Description and Page Index
Description: Homo sapiens alpha and gamma adaptin binding protein (AAGAB), transcript variant 2, mRNA. (from RefSeq NM_001271885) RefSeq Summary (NM_001271885): The protein encoded by this gene interacts with the gamma-adaptin and alpha-adaptin subunits of complexes involved in clathrin-coated vesicle trafficking. Mutations in this gene are associated with type I punctate palmoplantar keratoderma. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Dec 2012]. Gencode Transcript: ENST00000542650.5 Gencode Gene: ENSG00000103591.13 Transcript (Including UTRs) Position: hg38 chr15:67,202,740-67,255,195 Size: 52,456 Total Exon Count: 10 Strand: - Coding Region Position: hg38 chr15:67,202,821-67,236,441 Size: 33,621 Coding Exon Count: 8
ID:AAGAB_HUMAN DESCRIPTION: RecName: Full=Alpha- and gamma-adaptin-binding protein p34; FUNCTION: May play a role in membrane traffic (By similarity). SUBUNIT: Interacts with AP1G1 and AP2A1 (By similarity).
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
Pfam Domains: PF10199 - Alpha and gamma adaptin binding protein p34
ModBase Predicted Comparative 3D Structure on Q6PD74
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.