ID:TRPT1_HUMAN DESCRIPTION: RecName: Full=tRNA 2'-phosphotransferase 1; EC=184.108.40.206; FUNCTION: Catalyzes the last step of tRNA splicing, the transfer of the splice junction 2'-phosphate from ligated tRNA to NAD to produce ADP-ribose 1''-2'' cyclic phosphate (Probable). CATALYTIC ACTIVITY: 2'-phospho-[ligated tRNA] + NAD(+) = mature tRNA + ADP ribose 1'',2''-phosphate + nicotinamide + H(2)O. TISSUE SPECIFICITY: Widely expressed. Weakly or not expressed in lung, spleen, small intestine and peripheral blood leukocytes. SIMILARITY: Belongs to the KptA/TPT1 family.
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
Pfam Domains: PF01885 - RNA 2'-phosphotransferase, Tpt1 / KptA family
ModBase Predicted Comparative 3D Structure on Q86TN4
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.