Human Gene BACH2 (ENST00000537989.5) Description and Page Index
  Description: Homo sapiens BTB domain and CNC homolog 2 (BACH2), transcript variant 2, mRNA. (from RefSeq NM_001170794)
Gencode Transcript: ENST00000537989.5
Gencode Gene: ENSG00000112182.15
Transcript (Including UTRs)
   Position: hg38 chr6:89,926,529-90,296,908 Size: 370,380 Total Exon Count: 7 Strand: -
Coding Region
   Position: hg38 chr6:89,932,408-90,008,844 Size: 76,437 Coding Exon Count: 4 

Page IndexSequence and LinksUniProtKB CommentsMalaCardsCTDRNA-Seq Expression
Microarray ExpressionRNA StructureProtein StructureOther SpeciesGO AnnotationsmRNA Descriptions
Other NamesMethods
Data last updated: 2019-09-04

-  Sequence and Links to Tools and Databases
 
Genomic Sequence (chr6:89,926,529-90,296,908)mRNA (may differ from genome)Protein (841 aa)
Gene SorterGenome BrowserOther Species FASTAGene interactionsTable SchemaBioGPS
CGAPEnsemblEntrez GeneExonPrimerGeneCardsHGNC
HPRDLynxMGIneXtProtOMIMPubMed
Stanford SOURCEUniProtKBWikipedia

-  Comments and Description Text from UniProtKB
  ID: BACH2_HUMAN
DESCRIPTION: RecName: Full=Transcription regulator protein BACH2; AltName: Full=BTB and CNC homolog 2;
FUNCTION: Transcriptional regulator that acts as repressor or activator. Binds to Maf recognition elements (MARE). Play important roles in coordinating transcription activation and repression by MAFK (By similarity).
SUBUNIT: Heterodimer of BACH2 and Maf-related transcription factors (By similarity).
SUBCELLULAR LOCATION: Nucleus (By similarity).
TISSUE SPECIFICITY: B-cell specific.
SIMILARITY: Belongs to the bZIP family. CNC subfamily.
SIMILARITY: Contains 1 BTB (POZ) domain.
SIMILARITY: Contains 1 bZIP (basic-leucine zipper) domain.
SEQUENCE CAUTION: Sequence=BAD92126.1; Type=Erroneous initiation;

-  MalaCards Disease Associations
  MalaCards Gene Search: BACH2
Diseases sorted by gene-association score: lymphoma, non-hodgkin (1)

-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene           more ... click here to view the complete list

-  RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
  Highest median expression: 2.39 RPKM in Spleen
Total median expression: 43.35 RPKM



View in GTEx track of Genome Browser    View at GTEx portal     View GTEx Body Map

+  Microarray Expression Data
  Press "+" in the title bar above to open this section.

-  mRNA Secondary Structure of 3' and 5' UTRs
 
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -300.40703-0.427 Picture PostScript Text
3' UTR -1623.725879-0.276 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  InterPro Domains: Graphical view of domain structure
IPR000210 - BTB/POZ-like
IPR011333 - BTB/POZ_fold
IPR013069 - BTB_POZ
IPR004827 - bZIP
IPR008917 - Euk_TF_DNA-bd

Pfam Domains:
PF00651 - BTB/POZ domain
PF00170 - bZIP transcription factor

Protein Data Bank (PDB) 3-D Structure
MuPIT help

3OHU
- X-ray MuPIT

3OHV
- X-ray MuPIT


ModBase Predicted Comparative 3D Structure on Q9BYV9
FrontTopSide
The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
Genome BrowserGenome BrowserNo orthologNo orthologNo orthologNo ortholog
Gene Details     
Gene Sorter     
MGIRGD    
Protein SequenceProtein Sequence    
AlignmentAlignment    

-  Gene Ontology (GO) Annotations with Structured Vocabulary
  Molecular Function:
GO:0000980 RNA polymerase II distal enhancer sequence-specific DNA binding
GO:0000981 RNA polymerase II transcription factor activity, sequence-specific DNA binding
GO:0001206 transcriptional repressor activity, RNA polymerase II distal enhancer sequence-specific binding
GO:0003677 DNA binding
GO:0003700 transcription factor activity, sequence-specific DNA binding
GO:0004842 ubiquitin-protein transferase activity

Biological Process:
GO:0000122 negative regulation of transcription from RNA polymerase II promoter
GO:0006351 transcription, DNA-templated
GO:0006355 regulation of transcription, DNA-templated
GO:0006366 transcription from RNA polymerase II promoter
GO:0016567 protein ubiquitination
GO:0051170 nuclear import

Cellular Component:
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0005829 cytosol
GO:0031463 Cul3-RING ubiquitin ligase complex


-  Descriptions from all associated GenBank mRNAs
  LP896427 - Sequence 1291 from Patent EP3253886.
AJ271878 - Homo sapiens mRNA for putative transcription factor (BACH2 gene).
AB208889 - Homo sapiens mRNA for BTB and CNC homology 1, basic leucine zipper transcription factor 2 variant protein.
AF357835 - Homo sapiens BACH2 transcription factor mRNA, complete cds.
AK309526 - Homo sapiens cDNA, FLJ99567.
BC070239 - Homo sapiens cDNA clone IMAGE:30410294.
JD313006 - Sequence 294030 from Patent EP1572962.
JD566664 - Sequence 547688 from Patent EP1572962.
JD154021 - Sequence 135045 from Patent EP1572962.
JD232276 - Sequence 213300 from Patent EP1572962.
JD429092 - Sequence 410116 from Patent EP1572962.
JD538746 - Sequence 519770 from Patent EP1572962.
JD532179 - Sequence 513203 from Patent EP1572962.
JD053141 - Sequence 34165 from Patent EP1572962.
JD160673 - Sequence 141697 from Patent EP1572962.
JD466998 - Sequence 448022 from Patent EP1572962.
JD313450 - Sequence 294474 from Patent EP1572962.
JD530083 - Sequence 511107 from Patent EP1572962.
JD082479 - Sequence 63503 from Patent EP1572962.
JD357347 - Sequence 338371 from Patent EP1572962.
JD288268 - Sequence 269292 from Patent EP1572962.
AL512739 - Homo sapiens mRNA; cDNA DKFZp667E194 (from clone DKFZp667E194).
JD323823 - Sequence 304847 from Patent EP1572962.
JD079747 - Sequence 60771 from Patent EP1572962.
JD362596 - Sequence 343620 from Patent EP1572962.
JD037805 - Sequence 18829 from Patent EP1572962.
JD051836 - Sequence 32860 from Patent EP1572962.
JD263060 - Sequence 244084 from Patent EP1572962.
JD518723 - Sequence 499747 from Patent EP1572962.
JD410367 - Sequence 391391 from Patent EP1572962.
JD474339 - Sequence 455363 from Patent EP1572962.
JD485989 - Sequence 467013 from Patent EP1572962.
JD080669 - Sequence 61693 from Patent EP1572962.
JD246214 - Sequence 227238 from Patent EP1572962.
JD401876 - Sequence 382900 from Patent EP1572962.
JD195028 - Sequence 176052 from Patent EP1572962.
JD339411 - Sequence 320435 from Patent EP1572962.
JD471297 - Sequence 452321 from Patent EP1572962.
JD553964 - Sequence 534988 from Patent EP1572962.
JD314789 - Sequence 295813 from Patent EP1572962.
JD521173 - Sequence 502197 from Patent EP1572962.
JD494756 - Sequence 475780 from Patent EP1572962.
JD300420 - Sequence 281444 from Patent EP1572962.
JD403193 - Sequence 384217 from Patent EP1572962.
JD323475 - Sequence 304499 from Patent EP1572962.
JD414053 - Sequence 395077 from Patent EP1572962.
JD358640 - Sequence 339664 from Patent EP1572962.
JD245230 - Sequence 226254 from Patent EP1572962.
JD408844 - Sequence 389868 from Patent EP1572962.
JD372214 - Sequence 353238 from Patent EP1572962.
JD039828 - Sequence 20852 from Patent EP1572962.
JD550428 - Sequence 531452 from Patent EP1572962.
JD326648 - Sequence 307672 from Patent EP1572962.
JD506512 - Sequence 487536 from Patent EP1572962.
JD513359 - Sequence 494383 from Patent EP1572962.
JD381978 - Sequence 363002 from Patent EP1572962.
JD218983 - Sequence 200007 from Patent EP1572962.
JD466494 - Sequence 447518 from Patent EP1572962.
JD095090 - Sequence 76114 from Patent EP1572962.
JD213823 - Sequence 194847 from Patent EP1572962.
JD097323 - Sequence 78347 from Patent EP1572962.
JD155041 - Sequence 136065 from Patent EP1572962.
JD566709 - Sequence 547733 from Patent EP1572962.
JD260436 - Sequence 241460 from Patent EP1572962.
JD164859 - Sequence 145883 from Patent EP1572962.
JD556056 - Sequence 537080 from Patent EP1572962.
JD124279 - Sequence 105303 from Patent EP1572962.
JD104531 - Sequence 85555 from Patent EP1572962.
JD560770 - Sequence 541794 from Patent EP1572962.
JD297919 - Sequence 278943 from Patent EP1572962.
JD166927 - Sequence 147951 from Patent EP1572962.
JD389024 - Sequence 370048 from Patent EP1572962.
JD232981 - Sequence 214005 from Patent EP1572962.
JD432070 - Sequence 413094 from Patent EP1572962.
JD359293 - Sequence 340317 from Patent EP1572962.
JD204937 - Sequence 185961 from Patent EP1572962.
JD562592 - Sequence 543616 from Patent EP1572962.
JD048266 - Sequence 29290 from Patent EP1572962.
JD060911 - Sequence 41935 from Patent EP1572962.
JD501786 - Sequence 482810 from Patent EP1572962.
JD314867 - Sequence 295891 from Patent EP1572962.
JD210141 - Sequence 191165 from Patent EP1572962.
JD099608 - Sequence 80632 from Patent EP1572962.
JD317332 - Sequence 298356 from Patent EP1572962.
JD073416 - Sequence 54440 from Patent EP1572962.
JD054962 - Sequence 35986 from Patent EP1572962.
JD538605 - Sequence 519629 from Patent EP1572962.
JD097047 - Sequence 78071 from Patent EP1572962.
JD228930 - Sequence 209954 from Patent EP1572962.
JD081008 - Sequence 62032 from Patent EP1572962.
JD525878 - Sequence 506902 from Patent EP1572962.
JD288162 - Sequence 269186 from Patent EP1572962.
JD460169 - Sequence 441193 from Patent EP1572962.
JD325363 - Sequence 306387 from Patent EP1572962.
JD131126 - Sequence 112150 from Patent EP1572962.
JD321408 - Sequence 302432 from Patent EP1572962.
JD240007 - Sequence 221031 from Patent EP1572962.
BC166613 - Synthetic construct Homo sapiens clone IMAGE:100066339, MGC:195476 BTB and CNC homology 1, basic leucine zipper transcription factor 2 (BACH2) mRNA, encodes complete protein.
AB527277 - Synthetic construct DNA, clone: pF1KB3214, Homo sapiens BACH2 gene for basic leucine zipper transcription factor 2, without stop codon, in Flexi system.
HE578166 - Homo sapiens partial mRNA for BTB and CNC homology 1, basic leucine zipper transcription factor 2 (Bach2 gene), isolate PDX59 A2214G.
HE578165 - Homo sapiens partial mRNA for BTB and CNC homology 1, basic leucine zipper transcription factor 2 (Bach2 gene), isolate LAX9 C1779T.
HE578164 - Homo sapiens partial mRNA for BTB and CNC homology 1, basic leucine zipper transcription factor 2 (Bach2 gene), isolate ICN1 C1779T.
HE578167 - Homo sapiens partial mRNA for BTB and CNC homology 1, basic leucine zipper transcription factor 2 (Bach2 gene), isolate TXL2 C974T.
HE578168 - Homo sapiens partial mRNA for BTB and CNC homology 1, basic leucine zipper transcription factor 2 (Bach2 gene), isolate TXL3 C974T/C1039T.
HE578170 - Homo sapiens partial mRNA for BTB and CNC homology 1, basic leucine zipper transcription factor 2 (Bach2 gene), isolate SFO2 C1039T.
HE578172 - Homo sapiens partial mRNA for BTB and CNC homology 1, basic leucine zipper transcription factor 2 (Bach2 gene), isolate LAX9 C974T.
HE578174 - Homo sapiens partial mRNA for BTB and CNC homology 1, basic leucine zipper transcription factor 2 (Bach2 gene), isolate BLQ5 C974T.
HE578171 - Homo sapiens partial mRNA for BTB and CNC homology 1, basic leucine zipper transcription factor 2 (Bach2 gene), isolate LAX2 C974T.
HE578173 - Homo sapiens partial mRNA for BTB and CNC homology 1, basic leucine zipper transcription factor 2 (Bach2 gene), isolate BLQ1 C974T/C1039T.
HE578175 - Homo sapiens partial mRNA for BTB and CNC homology 1, basic leucine zipper transcription factor 2 (Bach2 gene), isolate BLQ11 C974T.
HE578176 - Homo sapiens partial mRNA for BTB and CNC homology 1, basic leucine zipper transcription factor 2 (Bach2 gene), isolate PDX59 C1039T.
HE578169 - Homo sapiens partial mRNA for BTB and CNC homology 1, basic leucine zipper transcription factor 2 (Bach2 gene), isolate ICN1 C974T/C1039T.
HE578163 - Homo sapiens partial mRNA for BTB and CNC homology 1, basic leucine zipper transcription factor 2 (Bach2 gene), isolate BLQ1 G938T.
JD404537 - Sequence 385561 from Patent EP1572962.
JD164339 - Sequence 145363 from Patent EP1572962.
JD104022 - Sequence 85046 from Patent EP1572962.
JD394239 - Sequence 375263 from Patent EP1572962.
JD149611 - Sequence 130635 from Patent EP1572962.
JD080967 - Sequence 61991 from Patent EP1572962.
JD167982 - Sequence 149006 from Patent EP1572962.
JD057386 - Sequence 38410 from Patent EP1572962.
JD468458 - Sequence 449482 from Patent EP1572962.
JD390047 - Sequence 371071 from Patent EP1572962.

-  Other Names for This Gene
  Alternate Gene Symbols: BACH2_HUMAN, E1P518, NM_001170794, Q59H70, Q5T793, Q9BYV9, Q9NTS5, uc003pnw.1, uc003pnw.2, uc003pnw.3, uc003pnw.4
UCSC ID: uc003pnw.4
RefSeq Accession: NM_001170794
Protein: Q9BYV9 (aka BACH2_HUMAN or BAC2_HUMAN)
CCDS: CCDS5026.1

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.