Human Gene WNK1 (ENST00000535572.5) Description and Page Index
  Description: Homo sapiens WNK lysine deficient protein kinase 1 (WNK1), transcript variant 2, mRNA. (from RefSeq NM_014823)
RefSeq Summary (NM_014823): This gene encodes a member of the WNK subfamily of serine/threonine protein kinases. The encoded protein may be a key regulator of blood pressure by controlling the transport of sodium and chloride ions. Mutations in this gene have been associated with pseudohypoaldosteronism type II and hereditary sensory neuropathy type II. Alternatively spliced transcript variants encoding different isoforms have been described but the full-length nature of all of them has yet to be determined.[provided by RefSeq, May 2010].
Gencode Transcript: ENST00000535572.5
Gencode Gene: ENSG00000060237.17
Transcript (Including UTRs)
   Position: hg38 chr12:752,593-911,300 Size: 158,708 Total Exon Count: 26 Strand: +
Coding Region
   Position: hg38 chr12:753,566-908,792 Size: 155,227 Coding Exon Count: 26 

Page IndexSequence and LinksUniProtKB CommentsMalaCardsCTDRNA-Seq Expression
Microarray ExpressionRNA StructureProtein StructureOther SpeciesGO AnnotationsmRNA Descriptions
Other NamesGeneReviewsMethods
Data last updated: 2019-09-04

-  Sequence and Links to Tools and Databases
 
Genomic Sequence (chr12:752,593-911,300)mRNA (may differ from genome)Protein (2134 aa)
Gene SorterGenome BrowserOther Species FASTAVisiGeneGene interactionsTable Schema
BioGPSCGAPEnsemblEntrez GeneExonPrimerGeneCards
HGNCLynxMGIOMIMPubMedStanford SOURCE
UniProtKBWikipedia

-  Comments and Description Text from UniProtKB
  ID: F5GWT4_HUMAN
DESCRIPTION: SubName: Full=Serine/threonine-protein kinase WNK1;
CAUTION: The sequence shown here is derived from an Ensembl automatic analysis pipeline and should be considered as preliminary data.

-  MalaCards Disease Associations
  MalaCards Gene Search: WNK1
Diseases sorted by gene-association score: neuropathy, hereditary sensory and autonomic, type ii* (1450), pseudohypoaldosteronism, type iic* (1350), pseudohypoaldosteronism (26), paronychia (13), neuropathy (13), arthrogryposis, distal, type 3 (12), autonomic neuropathy (12), familial hypertension (12), pseudohyperkalemia, familial, 2, due to red cell leak (9), autonomic dysfunction (7), renal tubular transport disease (7), insensitivity to pain, congenital (5), hypertension, essential (2)
* = Manually curated disease association

-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene           more ... click here to view the complete list

-  RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
  Highest median expression: 60.27 RPKM in Brain - Spinal cord (cervical c-1)
Total median expression: 1015.61 RPKM



View in GTEx track of Genome Browser    View at GTEx portal     View GTEx Body Map

+  Microarray Expression Data
  Press "+" in the title bar above to open this section.

-  mRNA Secondary Structure of 3' and 5' UTRs
 
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -521.60973-0.536 Picture PostScript Text
3' UTR -643.202508-0.256 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  InterPro Domains: Graphical view of domain structure
IPR011009 - Kinase-like_dom
IPR024678 - Kinase_OSR1/WNK_CCT
IPR000719 - Prot_kinase_cat_dom
IPR008271 - Ser/Thr_kinase_AS

Pfam Domains:
PF12202 - Oxidative-stress-responsive kinase 1 C-terminal domain
PF00069 - Protein kinase domain

ModBase Predicted Comparative 3D Structure on F5GWT4
FrontTopSide
The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
Genome BrowserGenome BrowserNo orthologNo orthologNo orthologNo ortholog
Gene Details     
Gene Sorter     
MGIRGD    
Protein SequenceProtein Sequence    
AlignmentAlignment    

-  Gene Ontology (GO) Annotations with Structured Vocabulary
  Molecular Function:
GO:0004672 protein kinase activity
GO:0004674 protein serine/threonine kinase activity
GO:0005524 ATP binding

Biological Process:
GO:0006468 protein phosphorylation

Cellular Component:
GO:0005829 cytosol


-  Descriptions from all associated GenBank mRNAs
  AF061944 - Homo sapiens kinase deficient protein KDP mRNA, partial cds.
LF384181 - JP 2014500723-A/191684: Polycomb-Associated Non-Coding RNAs.
MA619758 - JP 2018138019-A/191684: Polycomb-Associated Non-Coding RNAs.
BC021121 - Homo sapiens WNK lysine deficient protein kinase 1, mRNA (cDNA clone IMAGE:4653173), with apparent retained intron.
BC071959 - Homo sapiens WNK lysine deficient protein kinase 1, mRNA (cDNA clone IMAGE:4651132), with apparent retained intron.
BC094862 - Homo sapiens WNK lysine deficient protein kinase 1, mRNA (cDNA clone IMAGE:4650586), with apparent retained intron.
BC172444 - Synthetic construct Homo sapiens clone IMAGE:100069138, MGC:199149 WNK lysine deficient protein kinase 1 (WNK1) mRNA, encodes complete protein.
KJ903118 - Synthetic construct Homo sapiens clone ccsbBroadEn_12512 WNK1 gene, encodes complete protein.
KJ905529 - Synthetic construct Homo sapiens clone ccsbBroadEn_15140 WNK1 gene, encodes complete protein.
AJ296290 - Homo sapiens mRNA for putative protein kinase (WNK1 gene).
JQ358908 - Homo sapiens WNK lysine deficient protein kinase 1 isoform (WNK1) mRNA, complete cds, alternatively spliced.
BC141881 - Homo sapiens WNK lysine deficient protein kinase 1, mRNA (cDNA clone IMAGE:40126884), partial cds.
AB002342 - Homo sapiens mRNA for KIAA0344 gene, partial cds.
LF365544 - JP 2014500723-A/173047: Polycomb-Associated Non-Coding RNAs.
MA601121 - JP 2018138019-A/173047: Polycomb-Associated Non-Coding RNAs.
LF365542 - JP 2014500723-A/173045: Polycomb-Associated Non-Coding RNAs.
MA601119 - JP 2018138019-A/173045: Polycomb-Associated Non-Coding RNAs.
LF365541 - JP 2014500723-A/173044: Polycomb-Associated Non-Coding RNAs.
MA601118 - JP 2018138019-A/173044: Polycomb-Associated Non-Coding RNAs.
JD020646 - Sequence 1670 from Patent EP1572962.
JD036178 - Sequence 17202 from Patent EP1572962.
JD020671 - Sequence 1695 from Patent EP1572962.
JD029655 - Sequence 10679 from Patent EP1572962.
LF365540 - JP 2014500723-A/173043: Polycomb-Associated Non-Coding RNAs.
MA601117 - JP 2018138019-A/173043: Polycomb-Associated Non-Coding RNAs.
JD019614 - Sequence 638 from Patent EP1572962.
JD021269 - Sequence 2293 from Patent EP1572962.
JD030606 - Sequence 11630 from Patent EP1572962.
JD035859 - Sequence 16883 from Patent EP1572962.
JD035526 - Sequence 16550 from Patent EP1572962.
LF365538 - JP 2014500723-A/173041: Polycomb-Associated Non-Coding RNAs.
MA601115 - JP 2018138019-A/173041: Polycomb-Associated Non-Coding RNAs.
LF365530 - JP 2014500723-A/173033: Polycomb-Associated Non-Coding RNAs.
MA601107 - JP 2018138019-A/173033: Polycomb-Associated Non-Coding RNAs.
LF365526 - JP 2014500723-A/173029: Polycomb-Associated Non-Coding RNAs.
MA601103 - JP 2018138019-A/173029: Polycomb-Associated Non-Coding RNAs.
LF365525 - JP 2014500723-A/173028: Polycomb-Associated Non-Coding RNAs.
MA601102 - JP 2018138019-A/173028: Polycomb-Associated Non-Coding RNAs.
LF365523 - JP 2014500723-A/173026: Polycomb-Associated Non-Coding RNAs.
MA601100 - JP 2018138019-A/173026: Polycomb-Associated Non-Coding RNAs.
LF365522 - JP 2014500723-A/173025: Polycomb-Associated Non-Coding RNAs.
MA601099 - JP 2018138019-A/173025: Polycomb-Associated Non-Coding RNAs.
LF365521 - JP 2014500723-A/173024: Polycomb-Associated Non-Coding RNAs.
MA601098 - JP 2018138019-A/173024: Polycomb-Associated Non-Coding RNAs.
LF365520 - JP 2014500723-A/173023: Polycomb-Associated Non-Coding RNAs.
MA601097 - JP 2018138019-A/173023: Polycomb-Associated Non-Coding RNAs.
LF365495 - JP 2014500723-A/172998: Polycomb-Associated Non-Coding RNAs.
MA601072 - JP 2018138019-A/172998: Polycomb-Associated Non-Coding RNAs.
LF365494 - JP 2014500723-A/172997: Polycomb-Associated Non-Coding RNAs.
MA601071 - JP 2018138019-A/172997: Polycomb-Associated Non-Coding RNAs.
LF365493 - JP 2014500723-A/172996: Polycomb-Associated Non-Coding RNAs.
MA601070 - JP 2018138019-A/172996: Polycomb-Associated Non-Coding RNAs.
LF365492 - JP 2014500723-A/172995: Polycomb-Associated Non-Coding RNAs.
MA601069 - JP 2018138019-A/172995: Polycomb-Associated Non-Coding RNAs.
LF365490 - JP 2014500723-A/172993: Polycomb-Associated Non-Coding RNAs.
MA601067 - JP 2018138019-A/172993: Polycomb-Associated Non-Coding RNAs.
LF365489 - JP 2014500723-A/172992: Polycomb-Associated Non-Coding RNAs.
MA601066 - JP 2018138019-A/172992: Polycomb-Associated Non-Coding RNAs.
LF365488 - JP 2014500723-A/172991: Polycomb-Associated Non-Coding RNAs.
MA601065 - JP 2018138019-A/172991: Polycomb-Associated Non-Coding RNAs.
LF365486 - JP 2014500723-A/172989: Polycomb-Associated Non-Coding RNAs.
MA601063 - JP 2018138019-A/172989: Polycomb-Associated Non-Coding RNAs.
LF365482 - JP 2014500723-A/172985: Polycomb-Associated Non-Coding RNAs.
MA601059 - JP 2018138019-A/172985: Polycomb-Associated Non-Coding RNAs.
LF365481 - JP 2014500723-A/172984: Polycomb-Associated Non-Coding RNAs.
MA601058 - JP 2018138019-A/172984: Polycomb-Associated Non-Coding RNAs.
LF365479 - JP 2014500723-A/172982: Polycomb-Associated Non-Coding RNAs.
MA601056 - JP 2018138019-A/172982: Polycomb-Associated Non-Coding RNAs.
LF365478 - JP 2014500723-A/172981: Polycomb-Associated Non-Coding RNAs.
MA601055 - JP 2018138019-A/172981: Polycomb-Associated Non-Coding RNAs.
DQ925671 - Homo sapiens clone 2-1 WNK lysine deficient protein kinase 1 (WNK1) mRNA, partial cds, alternatively spliced.
DQ925672 - Homo sapiens clone 3B-4 WNK lysine deficient protein kinase 1 (WNK1) mRNA, partial cds, alternatively spliced.
DQ925669 - Homo sapiens clone 2A-3 WNK lysine deficient protein kinase 1 (WNK1) mRNA, partial cds, alternatively spliced.
DQ925670 - Homo sapiens clone 1B-2 WNK lysine deficient protein kinase 1 (WNK1) mRNA, partial cds, alternatively spliced.
BC013629 - Homo sapiens WNK lysine deficient protein kinase 1, mRNA (cDNA clone IMAGE:3445410), partial cds.
LF365468 - JP 2014500723-A/172971: Polycomb-Associated Non-Coding RNAs.
MA601045 - JP 2018138019-A/172971: Polycomb-Associated Non-Coding RNAs.
LF365466 - JP 2014500723-A/172969: Polycomb-Associated Non-Coding RNAs.
MA601043 - JP 2018138019-A/172969: Polycomb-Associated Non-Coding RNAs.
LF365465 - JP 2014500723-A/172968: Polycomb-Associated Non-Coding RNAs.
MA601042 - JP 2018138019-A/172968: Polycomb-Associated Non-Coding RNAs.
BC035146 - Homo sapiens cDNA clone IMAGE:5264735.
BC044600 - Homo sapiens cDNA clone IMAGE:4814776.
LF365463 - JP 2014500723-A/172966: Polycomb-Associated Non-Coding RNAs.
MA601040 - JP 2018138019-A/172966: Polycomb-Associated Non-Coding RNAs.
LF365462 - JP 2014500723-A/172965: Polycomb-Associated Non-Coding RNAs.
MA601039 - JP 2018138019-A/172965: Polycomb-Associated Non-Coding RNAs.
LF365461 - JP 2014500723-A/172964: Polycomb-Associated Non-Coding RNAs.
MA601038 - JP 2018138019-A/172964: Polycomb-Associated Non-Coding RNAs.
DQ580784 - Homo sapiens piRNA piR-48896, complete sequence.
LF365460 - JP 2014500723-A/172963: Polycomb-Associated Non-Coding RNAs.
MA601037 - JP 2018138019-A/172963: Polycomb-Associated Non-Coding RNAs.
LF365458 - JP 2014500723-A/172961: Polycomb-Associated Non-Coding RNAs.
MA601035 - JP 2018138019-A/172961: Polycomb-Associated Non-Coding RNAs.
LF365457 - JP 2014500723-A/172960: Polycomb-Associated Non-Coding RNAs.
MA601034 - JP 2018138019-A/172960: Polycomb-Associated Non-Coding RNAs.

-  Other Names for This Gene
  Alternate Gene Symbols: F5GWT4, F5GWT4_HUMAN, NM_014823, uc001qip.1, uc001qip.2, uc001qip.3, uc001qip.4, uc001qip.5
UCSC ID: uc001qip.5
RefSeq Accession: NM_014823
Protein: F5GWT4 CCDS: CCDS53731.1

-  GeneReviews for This Gene
  GeneReviews article(s) related to gene WNK1:
hsan2 (Hereditary Sensory and Autonomic Neuropathy Type II)
pha2 (Pseudohypoaldosteronism Type II)

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.