Human Gene ARHGAP27 (ENST00000532891.6) Description and Page Index
  Description: Contains 1 PH domain. (from UniProt E9PIR1)
RefSeq Summary (NM_001282290): This gene encodes a member of a large family of proteins that activate Rho-type guanosine triphosphate (GTP) metabolizing enzymes. The encoded protein may pay a role in clathrin-mediated endocytosis. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Aug 2013].
Gencode Transcript: ENST00000532891.6
Gencode Gene: ENSG00000159314.11
Transcript (Including UTRs)
   Position: hg38 chr17:45,395,456-45,430,279 Size: 34,824 Total Exon Count: 16 Strand: -
Coding Region
   Position: hg38 chr17:45,395,456-45,430,279 Size: 34,824 Coding Exon Count: 16 

Page IndexSequence and LinksUniProtKB CommentsCTDRNA-Seq ExpressionMicroarray Expression
Protein StructureOther SpeciesGO AnnotationsmRNA DescriptionsOther NamesMethods
Data last updated: 2019-09-04

-  Sequence and Links to Tools and Databases
Genomic Sequence (chr17:45,395,456-45,430,279)mRNA (may differ from genome)Protein (867 aa)
Gene SorterGenome BrowserOther Species FASTAGene interactionsTable SchemaBioGPS
MGIPubMedStanford SOURCEUniProtKBWikipedia

-  Comments and Description Text from UniProtKB
DESCRIPTION: SubName: Full=Rho GTPase-activating protein 27;
SIMILARITY: Contains 1 PH domain.
SIMILARITY: Contains 1 Rho-GAP domain.
CAUTION: The sequence shown here is derived from an Ensembl automatic analysis pipeline and should be considered as preliminary data.

-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene

-  RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
  Highest median expression: 41.44 RPKM in Whole Blood
Total median expression: 452.23 RPKM

View in GTEx track of Genome Browser    View at GTEx portal     View GTEx Body Map

+  Microarray Expression Data
  Press "+" in the title bar above to open this section.

-  Protein Domain and Structure Information
  InterPro Domains: Graphical view of domain structure
IPR011993 - PH_like_dom
IPR001849 - Pleckstrin_homology
IPR015767 - Rho_GTPase_activating
IPR008936 - Rho_GTPase_activation_prot
IPR000198 - RhoGAP_dom
IPR001452 - SH3_domain
IPR001202 - WW_Rsp5_WWP

Pfam Domains:
PF00169 - PH domain
PF00620 - RhoGAP domain
PF00397 - WW domain

ModBase Predicted Comparative 3D Structure on E9PIR1
The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
Genome BrowserGenome BrowserNo orthologNo orthologNo orthologNo ortholog
Gene Details     
Gene Sorter     
Protein SequenceProtein Sequence    

-  Gene Ontology (GO) Annotations with Structured Vocabulary
  Molecular Function:
GO:0005096 GTPase activator activity

Biological Process:
GO:0007165 signal transduction
GO:0043547 positive regulation of GTPase activity

Cellular Component:
GO:0005654 nucleoplasm
GO:0005829 cytosol

-  Descriptions from all associated GenBank mRNAs
  AK125535 - Homo sapiens cDNA FLJ43547 fis, clone PROST2016462.
BC101388 - Homo sapiens Rho GTPase activating protein 27, mRNA (cDNA clone MGC:120621 IMAGE:40026573), complete cds.
BC101389 - Homo sapiens Rho GTPase activating protein 27, mRNA (cDNA clone MGC:120622 IMAGE:40026575), complete cds.
BC101390 - Homo sapiens Rho GTPase activating protein 27, mRNA (cDNA clone MGC:120623 IMAGE:40026576), complete cds.
BC101391 - Homo sapiens Rho GTPase activating protein 27, mRNA (cDNA clone MGC:120624 IMAGE:40026577), complete cds.
AK300880 - Homo sapiens cDNA FLJ55812 complete cds, highly similar to Mus musculus Rho GTPase activating protein 27 (Arhgap27), transcript variant 1, mRNA.
LF209384 - JP 2014500723-A/16887: Polycomb-Associated Non-Coding RNAs.
MA444961 - JP 2018138019-A/16887: Polycomb-Associated Non-Coding RNAs.
AK290650 - Homo sapiens cDNA FLJ76025 complete cds.
BC067345 - Homo sapiens SH3 domain containing 20, mRNA (cDNA clone MGC:78393 IMAGE:6084901), complete cds.
AF258593 - Homo sapiens PP905 mRNA, complete cds.

-  Other Names for This Gene
  Alternate Gene Symbols: AK125535, E9PIR1, E9PIR1_HUMAN, uc060ghh.1
UCSC ID: uc060ghh.1
RefSeq Accession: NM_001282290
Protein: E9PIR1 CCDS: CCDS74082.1

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.