Human Gene ARHGAP27 (ENST00000532891.6) Description and Page Index
  Description: Contains 1 PH domain. (from UniProt E9PIR1)
RefSeq Summary (NM_001282290): This gene encodes a member of a large family of proteins that activate Rho-type guanosine triphosphate (GTP) metabolizing enzymes. The encoded protein may pay a role in clathrin-mediated endocytosis. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Aug 2013].
Gencode Transcript: ENST00000532891.6
Gencode Gene: ENSG00000159314.11
Transcript (Including UTRs)
   Position: hg38 chr17:45,395,456-45,430,279 Size: 34,824 Total Exon Count: 16 Strand: -
Coding Region
   Position: hg38 chr17:45,395,456-45,430,279 Size: 34,824 Coding Exon Count: 16 

Page IndexSequence and LinksUniProtKB CommentsCTDRNA-Seq ExpressionMicroarray Expression
Protein StructureOther SpeciesGO AnnotationsmRNA DescriptionsOther NamesMethods
Data last updated: 2019-09-04

-  Sequence and Links to Tools and Databases
 
Genomic Sequence (chr17:45,395,456-45,430,279)mRNA (may differ from genome)Protein (867 aa)
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-  Comments and Description Text from UniProtKB
  ID: E9PIR1_HUMAN
DESCRIPTION: SubName: Full=Rho GTPase-activating protein 27;
SIMILARITY: Contains 1 PH domain.
SIMILARITY: Contains 1 Rho-GAP domain.
CAUTION: The sequence shown here is derived from an Ensembl automatic analysis pipeline and should be considered as preliminary data.

-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene

-  RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
  Highest median expression: 41.44 RPKM in Whole Blood
Total median expression: 452.23 RPKM



View in GTEx track of Genome Browser    View at GTEx portal     View GTEx Body Map

+  Microarray Expression Data
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-  Protein Domain and Structure Information
  InterPro Domains: Graphical view of domain structure
IPR011993 - PH_like_dom
IPR001849 - Pleckstrin_homology
IPR015767 - Rho_GTPase_activating
IPR008936 - Rho_GTPase_activation_prot
IPR000198 - RhoGAP_dom
IPR001452 - SH3_domain
IPR001202 - WW_Rsp5_WWP

Pfam Domains:
PF00169 - PH domain
PF00620 - RhoGAP domain
PF00397 - WW domain

ModBase Predicted Comparative 3D Structure on E9PIR1
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-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
Genome BrowserGenome BrowserNo orthologNo orthologNo orthologNo ortholog
Gene Details     
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Protein SequenceProtein Sequence    
AlignmentAlignment    

-  Gene Ontology (GO) Annotations with Structured Vocabulary
  Molecular Function:
GO:0005096 GTPase activator activity

Biological Process:
GO:0007165 signal transduction
GO:0043547 positive regulation of GTPase activity

Cellular Component:
GO:0005654 nucleoplasm
GO:0005829 cytosol


-  Descriptions from all associated GenBank mRNAs
  AK125535 - Homo sapiens cDNA FLJ43547 fis, clone PROST2016462.
BC101388 - Homo sapiens Rho GTPase activating protein 27, mRNA (cDNA clone MGC:120621 IMAGE:40026573), complete cds.
BC101389 - Homo sapiens Rho GTPase activating protein 27, mRNA (cDNA clone MGC:120622 IMAGE:40026575), complete cds.
BC101390 - Homo sapiens Rho GTPase activating protein 27, mRNA (cDNA clone MGC:120623 IMAGE:40026576), complete cds.
BC101391 - Homo sapiens Rho GTPase activating protein 27, mRNA (cDNA clone MGC:120624 IMAGE:40026577), complete cds.
AK300880 - Homo sapiens cDNA FLJ55812 complete cds, highly similar to Mus musculus Rho GTPase activating protein 27 (Arhgap27), transcript variant 1, mRNA.
LF209384 - JP 2014500723-A/16887: Polycomb-Associated Non-Coding RNAs.
MA444961 - JP 2018138019-A/16887: Polycomb-Associated Non-Coding RNAs.
AK290650 - Homo sapiens cDNA FLJ76025 complete cds.
BC067345 - Homo sapiens SH3 domain containing 20, mRNA (cDNA clone MGC:78393 IMAGE:6084901), complete cds.
AF258593 - Homo sapiens PP905 mRNA, complete cds.

-  Other Names for This Gene
  Alternate Gene Symbols: AK125535, E9PIR1, E9PIR1_HUMAN, uc060ghh.1
UCSC ID: uc060ghh.1
RefSeq Accession: NM_001282290
Protein: E9PIR1 CCDS: CCDS74082.1

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.