Human Gene PRDM10 (ENST00000528746.5) Description and Page Index
  Description: The sequence shown here is derived from an Ensembl automatic analysis pipeline and should be considered as preliminary data. (from UniProt E9PLV1)
RefSeq Summary (NM_001367893): The protein encoded by this gene is a transcription factor that contains C2H2-type zinc-fingers. It also contains a positive regulatory domain, which has been found in several other zinc-finger transcription factors including those involved in B cell differentiation and tumor suppression. Studies of the mouse counterpart suggest that this protein may be involved in the development of the central nerve system (CNS), as well as in the pathogenesis of neuronal storage disease. Multiple alternatively spliced transcript variants encoding distinct isoforms have been observed. [provided by RefSeq, Jul 2008]. Sequence Note: The RefSeq transcript and protein were derived from genomic sequence to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on alignments. ##Evidence-Data-START## Transcript exon combination :: SRR1660807.105843.1, SRR1803611.78278.1 [ECO:0000332] RNAseq introns :: mixed/partial sample support SAMEA1965299, SAMEA1966682 [ECO:0000350] ##Evidence-Data-END##
Gencode Transcript: ENST00000528746.5
Gencode Gene: ENSG00000170325.14
Transcript (Including UTRs)
   Position: hg38 chr11:129,899,717-130,002,835 Size: 103,119 Total Exon Count: 21 Strand: -
Coding Region
   Position: hg38 chr11:129,902,313-129,960,964 Size: 58,652 Coding Exon Count: 20 

Page IndexSequence and LinksUniProtKB CommentsMalaCardsCTDRNA-Seq Expression
Microarray ExpressionRNA StructureProtein StructureOther SpeciesGO AnnotationsmRNA Descriptions
Other NamesMethods
Data last updated: 2019-09-04

-  Sequence and Links to Tools and Databases
Genomic Sequence (chr11:129,899,717-130,002,835)mRNA (may differ from genome)Protein (1117 aa)
Gene SorterGenome BrowserOther Species FASTAGene interactionsTable SchemaBioGPS
MGIPubMedStanford SOURCEUniProtKB

-  Comments and Description Text from UniProtKB
DESCRIPTION: SubName: Full=PR domain zinc finger protein 10;
CAUTION: The sequence shown here is derived from an Ensembl automatic analysis pipeline and should be considered as preliminary data.

-  MalaCards Disease Associations
  MalaCards Gene Search: PRDM10
Diseases sorted by gene-association score: intraventricular meningioma (16), tinea unguium (9), pyosalpinx (9), corneal dystrophy, congenital stromal (7), branch retinal artery occlusion (7), uterine benign neoplasm (6), retinitis pigmentosa, y-linked (6), reproductive organ benign neoplasm (5)

-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene

-  RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
  Highest median expression: 6.44 RPKM in Brain - Cerebellar Hemisphere
Total median expression: 112.91 RPKM

View in GTEx track of Genome Browser    View at GTEx portal     View GTEx Body Map

+  Microarray Expression Data
  Press "+" in the title bar above to open this section.

-  mRNA Secondary Structure of 3' and 5' UTRs
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -91.00232-0.392 Picture PostScript Text
3' UTR -642.602596-0.248 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  InterPro Domains: Graphical view of domain structure
IPR007087 - Znf_C2H2
IPR015880 - Znf_C2H2-like
IPR013087 - Znf_C2H2/integrase_DNA-bd
IPR022755 - Znf_C2H2_jaz

Pfam Domains:
PF00096 - Zinc finger, C2H2 type
PF12171 - Zinc-finger double-stranded RNA-binding

ModBase Predicted Comparative 3D Structure on E9PLV1
The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
Genome BrowserGenome BrowserNo orthologNo orthologNo orthologNo ortholog
Gene Details     
Gene Sorter     
Protein SequenceProtein Sequence    

-  Gene Ontology (GO) Annotations with Structured Vocabulary
  Molecular Function:
GO:0003676 nucleic acid binding
GO:0046872 metal ion binding

-  Descriptions from all associated GenBank mRNAs
  BX648944 - Homo sapiens mRNA; cDNA DKFZp686C1648 (from clone DKFZp686C1648).
AF503171 - Homo sapiens tristanin mRNA, complete cds.
AF275817 - Homo sapiens PR-domain containing protein 10 (PRDM10) mRNA, complete cds.
AB033057 - Homo sapiens KIAA1231 mRNA for KIAA1231 protein.
AL833172 - Homo sapiens mRNA; cDNA DKFZp686I125 (from clone DKFZp686I125).
LF208406 - JP 2014500723-A/15909: Polycomb-Associated Non-Coding RNAs.
MA443983 - JP 2018138019-A/15909: Polycomb-Associated Non-Coding RNAs.
BC112934 - Homo sapiens PR domain containing 10, mRNA (cDNA clone MGC:131802 IMAGE:6502888), complete cds.
JD046696 - Sequence 27720 from Patent EP1572962.
JD080605 - Sequence 61629 from Patent EP1572962.
LF375934 - JP 2014500723-A/183437: Polycomb-Associated Non-Coding RNAs.
MA611511 - JP 2018138019-A/183437: Polycomb-Associated Non-Coding RNAs.
JD412347 - Sequence 393371 from Patent EP1572962.
JD331957 - Sequence 312981 from Patent EP1572962.
JD556703 - Sequence 537727 from Patent EP1572962.
JD556701 - Sequence 537725 from Patent EP1572962.
JD556700 - Sequence 537724 from Patent EP1572962.
JD556699 - Sequence 537723 from Patent EP1572962.
JD520041 - Sequence 501065 from Patent EP1572962.
JD167013 - Sequence 148037 from Patent EP1572962.
JD557975 - Sequence 538999 from Patent EP1572962.
JD298646 - Sequence 279670 from Patent EP1572962.
JD323376 - Sequence 304400 from Patent EP1572962.
JD299250 - Sequence 280274 from Patent EP1572962.
JD229109 - Sequence 210133 from Patent EP1572962.
JD286366 - Sequence 267390 from Patent EP1572962.
LF375931 - JP 2014500723-A/183434: Polycomb-Associated Non-Coding RNAs.
MA611508 - JP 2018138019-A/183434: Polycomb-Associated Non-Coding RNAs.
JD415705 - Sequence 396729 from Patent EP1572962.
JD171649 - Sequence 152673 from Patent EP1572962.
JD260485 - Sequence 241509 from Patent EP1572962.
LF375930 - JP 2014500723-A/183433: Polycomb-Associated Non-Coding RNAs.
MA611507 - JP 2018138019-A/183433: Polycomb-Associated Non-Coding RNAs.
JD235854 - Sequence 216878 from Patent EP1572962.
JD264960 - Sequence 245984 from Patent EP1572962.
JD198731 - Sequence 179755 from Patent EP1572962.
JD109875 - Sequence 90899 from Patent EP1572962.
JD471087 - Sequence 452111 from Patent EP1572962.
BC117415 - Homo sapiens PR domain containing 10, mRNA (cDNA clone MGC:151024 IMAGE:40125966), complete cds.
BC143613 - Homo sapiens PR domain containing 10, mRNA (cDNA clone MGC:177143 IMAGE:9052126), complete cds.
BC143612 - Homo sapiens PR domain containing 10, mRNA (cDNA clone MGC:177142 IMAGE:9052125), complete cds.
KU720378 - Homo sapiens PR domain containing 10 isoform 2 (PRDM10) mRNA, complete cds.
AB385439 - Synthetic construct DNA, clone: pF1KA1231, Homo sapiens PRDM10 gene for PR domain zinc finger protein 10, complete cds, without stop codon, in Flexi system.
AK000234 - Homo sapiens cDNA FLJ20227 fis, clone COLF5152.
AK310354 - Homo sapiens cDNA, FLJ17396.

-  Other Names for This Gene
  Alternate Gene Symbols: BX648944, E9PLV1, E9PLV1_HUMAN, uc058jcf.1
UCSC ID: uc058jcf.1
RefSeq Accession: NM_001367893
Protein: E9PLV1 CCDS: CCDS8484.1, CCDS44771.1

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.