ID:NKX31_HUMAN DESCRIPTION: RecName: Full=Homeobox protein Nkx-3.1; AltName: Full=Homeobox protein NK-3 homolog A; FUNCTION: Transcription factor, which binds preferentially the consensus sequence 5'-TAAGT[AG]-3' and can behave as a transcriptional repressor. Plays an important role in normal prostate development, regulating proliferation of glandular epithelium and in the formation of ducts in prostate. Acts as a tumor suppressor controlling prostate carcinogenesis, as shown by the ability to inhibit proliferation and invasion activities of PC-3 prostate cancer cells. SUBUNIT: Interacts with serum response factor (SRF) (By similarity). Interacts with SPDEF. Interacts with WDR77. Interacts with TOPORS which polyubiquitinates NKX3-1 and induces its proteasomal degradation. INTERACTION: P11387:TOP1; NbExp=6; IntAct=EBI-1385894, EBI-876302; SUBCELLULAR LOCATION: Nucleus. TISSUE SPECIFICITY: Highly expressed in the prostate and, at a lower level, in the testis. INDUCTION: By androgens and, in the LNCaP cell line, by estrogens. Androgenic control may be lost in prostate cancer cells during tumor progression from an androgen-dependent to an androgen- independent phase. PTM: Ubiquitinated by TOPORS; monoubiquitinated at several residues and also polyubiquitinated on single residues. SIMILARITY: Belongs to the NK-3 homeobox family. SIMILARITY: Contains 1 homeobox DNA-binding domain.
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on Q99801
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
Gene Ontology (GO) Annotations with Structured Vocabulary
Molecular Function: GO:0000976 transcription regulatory region sequence-specific DNA binding GO:0000981 RNA polymerase II transcription factor activity, sequence-specific DNA binding GO:0000983 transcription factor activity, RNA polymerase II core promoter sequence-specific GO:0001047 core promoter binding GO:0003677 DNA binding GO:0003700 transcription factor activity, sequence-specific DNA binding GO:0004882 androgen receptor activity GO:0005515 protein binding GO:0008134 transcription factor binding GO:0030284 estrogen receptor activity GO:0030295 protein kinase activator activity GO:0030331 estrogen receptor binding GO:0042826 histone deacetylase binding GO:0043565 sequence-specific DNA binding GO:0043621 protein self-association GO:0044212 transcription regulatory region DNA binding GO:0097162 MADS box domain binding GO:0008656 cysteine-type endopeptidase activator activity involved in apoptotic process
Biological Process: GO:0001655 urogenital system development GO:0001656 metanephros development GO:0001756 somitogenesis GO:0001934 positive regulation of protein phosphorylation GO:0006351 transcription, DNA-templated GO:0006355 regulation of transcription, DNA-templated GO:0006919 activation of cysteine-type endopeptidase activity involved in apoptotic process GO:0007275 multicellular organism development GO:0007431 salivary gland development GO:0007507 heart development GO:0008284 positive regulation of cell proliferation GO:0008285 negative regulation of cell proliferation GO:0008584 male gonad development GO:0010628 positive regulation of gene expression GO:0010629 negative regulation of gene expression GO:0010942 positive regulation of cell death GO:0014068 positive regulation of phosphatidylinositol 3-kinase signaling GO:0030521 androgen receptor signaling pathway GO:0030850 prostate gland development GO:0032147 activation of protein kinase activity GO:0033574 response to testosterone GO:0035690 cellular response to drug GO:0035907 dorsal aorta development GO:0043280 positive regulation of cysteine-type endopeptidase activity involved in apoptotic process GO:0043491 protein kinase B signaling GO:0043569 negative regulation of insulin-like growth factor receptor signaling pathway GO:0045892 negative regulation of transcription, DNA-templated GO:0045893 positive regulation of transcription, DNA-templated GO:0045930 negative regulation of mitotic cell cycle GO:0045931 positive regulation of mitotic cell cycle GO:0045944 positive regulation of transcription from RNA polymerase II promoter GO:0048754 branching morphogenesis of an epithelial tube GO:0050680 negative regulation of epithelial cell proliferation GO:0051781 positive regulation of cell division GO:0060037 pharyngeal system development GO:0060442 branching involved in prostate gland morphogenesis GO:0060664 epithelial cell proliferation involved in salivary gland morphogenesis GO:0060770 negative regulation of epithelial cell proliferation involved in prostate gland development GO:0071347 cellular response to interleukin-1 GO:0071356 cellular response to tumor necrosis factor GO:0071383 cellular response to steroid hormone stimulus GO:0071456 cellular response to hypoxia GO:0071850 mitotic cell cycle arrest GO:0071899 negative regulation of estrogen receptor binding GO:2000836 positive regulation of androgen secretion GO:2001022 positive regulation of response to DNA damage stimulus GO:2001235 positive regulation of apoptotic signaling pathway GO:2001244 positive regulation of intrinsic apoptotic signaling pathway