Human Gene TRIQK (ENST00000521988.6) Description and Page Index
  Description: Homo sapiens triple QxxK/R motif containing (TRIQK), transcript variant 6, mRNA. (from RefSeq NM_001191035)
Gencode Transcript: ENST00000521988.6
Gencode Gene: ENSG00000205133.12
Transcript (Including UTRs)
   Position: hg38 chr8:92,883,534-92,966,144 Size: 82,611 Total Exon Count: 5 Strand: -
Coding Region
   Position: hg38 chr8:92,886,622-92,916,989 Size: 30,368 Coding Exon Count: 3 

Page IndexSequence and LinksUniProtKB CommentsCTDRNA-Seq ExpressionRNA Structure
Protein StructureOther SpeciesGO AnnotationsmRNA DescriptionsOther NamesMethods
Data last updated: 2019-09-04

-  Sequence and Links to Tools and Databases
Genomic Sequence (chr8:92,883,534-92,966,144)mRNA (may differ from genome)Protein (86 aa)
Gene SorterGenome BrowserOther Species FASTATable SchemaBioGPSCGAP
EnsemblEntrez GeneExonPrimerGeneCardsHGNCLynx
MGIneXtProtPubMedStanford SOURCEUniProtKB

-  Comments and Description Text from UniProtKB
DESCRIPTION: RecName: Full=Triple QxxK/R motif-containing protein; AltName: Full=Triple repetitive-sequence of QXXK/R protein homolog;
FUNCTION: May play a role in cell growth and maintenance of cell morphology (By similarity).
SUBCELLULAR LOCATION: Endoplasmic reticulum membrane; Single-pass membrane protein.
SIMILARITY: Belongs to the TRIQK family.

-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene
  • C532162 2-(1H-indazol-4-yl)-6-(4-methanesulfonylpiperazin-1-ylmethyl)-4-morpholin-4-ylthieno(3,2-d)pyrimidine
  • D015123 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide
  • D008627 Mercuric Chloride
  • D015215 Zidovudine
  • C088658 zoledronic acid

-  RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
  Highest median expression: 2.39 RPKM in Cells - Transformed fibroblasts
Total median expression: 55.68 RPKM

View in GTEx track of Genome Browser    View at GTEx portal     View GTEx Body Map

-  mRNA Secondary Structure of 3' and 5' UTRs
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -90.20318-0.284 Picture PostScript Text
3' UTR -688.903088-0.223 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  InterPro Domains: Graphical view of domain structure
IPR024842 - TRIQK

ModBase Predicted Comparative 3D Structure on Q629K1
The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
Genome BrowserGenome BrowserNo orthologNo orthologNo orthologNo ortholog
Gene Details     
Gene Sorter     
Protein SequenceProtein Sequence    

-  Gene Ontology (GO) Annotations with Structured Vocabulary
  Cellular Component:
GO:0005783 endoplasmic reticulum
GO:0005789 endoplasmic reticulum membrane
GO:0016020 membrane
GO:0016021 integral component of membrane

-  Descriptions from all associated GenBank mRNAs
  BC110326 - Homo sapiens cDNA clone IMAGE:5555490.
AK097956 - Homo sapiens cDNA FLJ40637 fis, clone THYMU2015984.
CR749421 - Homo sapiens mRNA; cDNA DKFZp779L1068 (from clone DKFZp779L1068).
DQ351291 - Homo sapiens triqk mRNA, complete cds.
BC031029 - Homo sapiens cDNA clone IMAGE:4723870.
BC065838 - Homo sapiens cDNA clone IMAGE:30385138, partial cds.
AK096398 - Homo sapiens cDNA FLJ39079 fis, clone NT2RP7018032.
BC104255 - Homo sapiens chromosome 8 open reading frame 83, mRNA (cDNA clone IMAGE:40035935).
BC104254 - Homo sapiens chromosome 8 open reading frame 83, mRNA (cDNA clone IMAGE:40035934).
BC113007 - Homo sapiens chromosome 8 open reading frame 83, mRNA (cDNA clone IMAGE:40035932).
BC113008 - Homo sapiens chromosome 8 open reading frame 83, mRNA (cDNA clone IMAGE:40035933).

-  Other Names for This Gene
  Alternate Gene Symbols: C8orf83, NM_001191035, Q629K1, TRIQK_HUMAN, uc010map.1, uc010map.2, uc010map.3, uc010map.4, uc010map.5
UCSC ID: uc010map.5
RefSeq Accession: NM_001171797
Protein: Q629K1 (aka TRIQK_HUMAN)
CCDS: CCDS55261.1

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.