Human Gene CCNE2 (ENST00000520509.5) Description and Page Index
Description: Essential for the control of the cell cycle at the late G1 and early S phase. (from UniProt O96020) RefSeq Summary (NM_057749): The protein encoded by this gene belongs to the highly conserved cyclin family, whose members are characterized by a dramatic periodicity in protein abundance through the cell cycle. Cyclins function as regulators of CDK kinases. Different cyclins exhibit distinct expression and degradation patterns which contribute to the temporal coordination of each mitotic event. This cyclin forms a complex with and functions as a regulatory subunit of CDK2. This cyclin has been shown to specifically interact with CIP/KIP family of CDK inhibitors, and plays a role in cell cycle G1/S transition. The expression of this gene peaks at the G1-S phase and exhibits a pattern of tissue specificity distinct from that of cyclin E1. A significantly increased expression level of this gene was observed in tumor-derived cells. [provided by RefSeq, Jul 2008]. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: SRR1660805.199067.1, SRR1660807.186854.1 [ECO:0000332] RNAseq introns :: mixed/partial sample support SAMEA1965299, SAMEA1966682 [ECO:0000350] ##Evidence-Data-END## ##RefSeq-Attributes-START## RefSeq Select criteria :: based on conservation, expression, longest protein ##RefSeq-Attributes-END## Gencode Transcript: ENST00000520509.5 Gencode Gene: ENSG00000175305.17 Transcript (Including UTRs) Position: hg38 chr8:94,879,770-94,896,678 Size: 16,909 Total Exon Count: 12 Strand: - Coding Region Position: hg38 chr8:94,881,632-94,894,221 Size: 12,590 Coding Exon Count: 11
ID:CCNE2_HUMAN DESCRIPTION: RecName: Full=G1/S-specific cyclin-E2; FUNCTION: Essential for the control of the cell cycle at the late G1 and early S phase. SUBUNIT: Interacts with the CDK2 (in vivo) and CDK3 (in vitro) protein kinases to form a serine/threonine kinase holoenzyme complex. The cyclin subunit imparts substrate specificity to the complex. INTERACTION: P24941:CDK2; NbExp=5; IntAct=EBI-375033, EBI-375096; P38936:CDKN1A; NbExp=2; IntAct=EBI-375033, EBI-375077; P46527:CDKN1B; NbExp=2; IntAct=EBI-375033, EBI-519280; SUBCELLULAR LOCATION: Nucleus. TISSUE SPECIFICITY: According to PubMed:9858585, highest levels of expression in adult testis, thymus and brain. Lower levels in placenta, spleen and colon. Consistently elevated levels in tumor- derived cells compared to non-transformed proliferating cells. According to PubMed:9840927: low levels in thymus, prostate, brain, skeletal muscle, and kidney. Elevated levels in lung. According to PubMed:9840943 highly expressed in testis, placenta, thymus and brain. In a lesser extent in small intestine and colon. INDUCTION: Activated by papilloma viral oncoproteins E6 and E7 which bind to and inactivate p53 and Rb, respectively. PTM: Phosphorylation by CDK2 triggers its release from CDK2 and degradation via the ubiquitin proteasome pathway (By similarity). SIMILARITY: Belongs to the cyclin family. Cyclin E subfamily. WEB RESOURCE: Name=NIEHS-SNPs; URL="http://egp.gs.washington.edu/data/ccne2/";
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on O96020
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.