Human Gene MTDH (ENST00000519934.5) Description and Page Index
  Description: Homo sapiens metadherin (MTDH), transcript variant 5, mRNA. (from RefSeq NM_001363139)
Gencode Transcript: ENST00000519934.5
Gencode Gene: ENSG00000147649.10
Transcript (Including UTRs)
   Position: hg38 chr8:97,644,546-97,725,243 Size: 80,698 Total Exon Count: 11 Strand: +
Coding Region
   Position: hg38 chr8:97,644,576-97,724,670 Size: 80,095 Coding Exon Count: 11 

Page IndexSequence and LinksUniProtKB CommentsMalaCardsCTDRNA-Seq Expression
Microarray ExpressionRNA StructureProtein StructureOther SpeciesGO AnnotationsmRNA Descriptions
Other NamesMethods
Data last updated: 2019-09-04

-  Sequence and Links to Tools and Databases
Genomic Sequence (chr8:97,644,546-97,725,243)mRNA (may differ from genome)Protein (526 aa)
Gene SorterGenome BrowserOther Species FASTAGene interactionsTable SchemaBioGPS
CGAPEnsemblEntrez GeneExonPrimerGeneCardsHGNC

-  Comments and Description Text from UniProtKB
DESCRIPTION: SubName: Full=Protein LYRIC;
CAUTION: The sequence shown here is derived from an Ensembl automatic analysis pipeline and should be considered as preliminary data.

-  MalaCards Disease Associations
  MalaCards Gene Search: MTDH
Diseases sorted by gene-association score: nervous system disease (2), central nervous system disease (2)

-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene           more ... click here to view the complete list

-  RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
  Highest median expression: 54.08 RPKM in Cells - EBV-transformed lymphocytes
Total median expression: 774.70 RPKM

View in GTEx track of Genome Browser    View at GTEx portal     View GTEx Body Map

+  Microarray Expression Data
  Press "+" in the title bar above to open this section.

-  mRNA Secondary Structure of 3' and 5' UTRs
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -14.7030-0.490 Picture PostScript Text
3' UTR -110.20573-0.192 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  ModBase Predicted Comparative 3D Structure on E5RJU9
The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
Genome BrowserGenome BrowserNo orthologNo orthologNo orthologNo ortholog
Gene Details     
Gene Sorter     
Protein SequenceProtein Sequence    

-  Gene Ontology (GO) Annotations with Structured Vocabulary
  Biological Process:
GO:0043066 negative regulation of apoptotic process
GO:0043123 positive regulation of I-kappaB kinase/NF-kappaB signaling
GO:0045766 positive regulation of angiogenesis

Cellular Component:
GO:0005783 endoplasmic reticulum
GO:0016020 membrane
GO:0016021 integral component of membrane

-  Descriptions from all associated GenBank mRNAs
  BC045642 - Homo sapiens metadherin, mRNA (cDNA clone MGC:41931 IMAGE:5298467), complete cds.
BC001815 - Homo sapiens metadherin, mRNA (cDNA clone IMAGE:2989261).
BC014977 - Homo sapiens metadherin, mRNA (cDNA clone IMAGE:4859424), partial cds.
AF501310 - Homo sapiens LYRIC/3D3 mRNA, complete cds.
BC022825 - Homo sapiens metadherin, mRNA (cDNA clone IMAGE:5089169).
BC009324 - Homo sapiens metadherin, mRNA (cDNA clone IMAGE:4124124), partial cds.
AF411226 - Homo sapiens astrocyte elevated gene-1 AEG1 mRNA, complete cds.
AY082966 - Homo sapiens LYRIC mRNA, complete cds.
AY974040 - Homo sapiens LYRIC (LYRIC) mRNA, complete cds.
JF432755 - Synthetic construct Homo sapiens clone IMAGE:100073999 metadherin (MTDH) gene, encodes complete protein.
KJ899936 - Synthetic construct Homo sapiens clone ccsbBroadEn_09330 MTDH gene, encodes complete protein.
AK000745 - Homo sapiens cDNA FLJ20738 fis, clone HEP08257.
JD024333 - Sequence 5357 from Patent EP1572962.
JD033404 - Sequence 14428 from Patent EP1572962.
AK308030 - Homo sapiens cDNA, FLJ97978.
BC023994 - Homo sapiens metadherin, mRNA (cDNA clone IMAGE:4079105).
JD090725 - Sequence 71749 from Patent EP1572962.
JD446324 - Sequence 427348 from Patent EP1572962.
AL117594 - Homo sapiens mRNA; cDNA DKFZp564C1563 (from clone DKFZp564C1563).
JD063029 - Sequence 44053 from Patent EP1572962.
JD309455 - Sequence 290479 from Patent EP1572962.
JD429737 - Sequence 410761 from Patent EP1572962.
JD168162 - Sequence 149186 from Patent EP1572962.

-  Other Names for This Gene
  Alternate Gene Symbols: E5RJU9, E5RJU9_HUMAN, NM_001363139, uc064ove.1
UCSC ID: uc064ove.1
RefSeq Accession: NM_001363138
Protein: E5RJU9

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.