ID:TFIP8_HUMAN DESCRIPTION: RecName: Full=Tumor necrosis factor alpha-induced protein 8; Short=TNF alpha-induced protein 8; AltName: Full=Head and neck tumor and metastasis-related protein; AltName: Full=MDC-3.13; AltName: Full=NF-kappa-B-inducible DED-containing protein; Short=NDED; AltName: Full=SCC-S2; AltName: Full=TNF-induced protein GG2-1; FUNCTION: Acts as a negative mediator of apoptosis and may play a role in tumor progression. Suppresses the TNF-mediated apoptosis by inhibiting caspase-8 activity but not the processing of procaspase-8, subsequently resulting in inhibition of BID cleavage and caspase-3 activation. SUBCELLULAR LOCATION: Cytoplasm. TISSUE SPECIFICITY: Expressed at high levels in the spleen, lymph node, thymus, thyroid, bone marrow and placenta. Expressed at high levels both in various tumor tissues, unstimulated and cytokine- activated cultured cells. Expressed at low levels in the spinal cord, ovary, lung, adrenal glands, heart, brain, testis and skeletal muscle. DEVELOPMENTAL STAGE: Expressed at high levels in the fetal liver, lung and kidney. INDUCTION: By nuclear factor-KB (NF-KB) and TNF. Induction by TNF depends upon activation of NF-KB. SIMILARITY: Belongs to the TNFAIP8 family.
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
Pfam Domains: PF05527 - Domain of unknown function (DUF758)
ModBase Predicted Comparative 3D Structure on O95379
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
Gene Ontology (GO) Annotations with Structured Vocabulary
Molecular Function: GO:0005515 protein binding GO:0043027 cysteine-type endopeptidase inhibitor activity involved in apoptotic process
Biological Process: GO:0006915 apoptotic process GO:0042981 regulation of apoptotic process GO:0043065 positive regulation of apoptotic process GO:0043066 negative regulation of apoptotic process GO:0043154 negative regulation of cysteine-type endopeptidase activity involved in apoptotic process