Human Gene TNFAIP8 (ENST00000513374.1) Description and Page Index
  Description: Homo sapiens TNF alpha induced protein 8 (TNFAIP8), transcript variant 4, mRNA. (from RefSeq NM_001286814)
Gencode Transcript: ENST00000513374.1
Gencode Gene: ENSG00000145779.8
Transcript (Including UTRs)
   Position: hg38 chr5:119,333,175-119,393,743 Size: 60,569 Total Exon Count: 2 Strand: +
Coding Region
   Position: hg38 chr5:119,333,565-119,393,381 Size: 59,817 Coding Exon Count: 2 

Page IndexSequence and LinksUniProtKB CommentsCTDRNA-Seq ExpressionMicroarray Expression
RNA StructureProtein StructureOther SpeciesGO AnnotationsmRNA DescriptionsPathways
Other NamesMethods
Data last updated: 2019-09-04

-  Sequence and Links to Tools and Databases
Genomic Sequence (chr5:119,333,175-119,393,743)mRNA (may differ from genome)Protein (210 aa)
Gene SorterGenome BrowserOther Species FASTAGene interactionsTable SchemaBioGPS
CGAPEnsemblEntrez GeneExonPrimerGeneCardsHGNC
ReactomeStanford SOURCEUniProtKBWikipedia

-  Comments and Description Text from UniProtKB
DESCRIPTION: RecName: Full=Tumor necrosis factor alpha-induced protein 8; Short=TNF alpha-induced protein 8; AltName: Full=Head and neck tumor and metastasis-related protein; AltName: Full=MDC-3.13; AltName: Full=NF-kappa-B-inducible DED-containing protein; Short=NDED; AltName: Full=SCC-S2; AltName: Full=TNF-induced protein GG2-1;
FUNCTION: Acts as a negative mediator of apoptosis and may play a role in tumor progression. Suppresses the TNF-mediated apoptosis by inhibiting caspase-8 activity but not the processing of procaspase-8, subsequently resulting in inhibition of BID cleavage and caspase-3 activation.
TISSUE SPECIFICITY: Expressed at high levels in the spleen, lymph node, thymus, thyroid, bone marrow and placenta. Expressed at high levels both in various tumor tissues, unstimulated and cytokine- activated cultured cells. Expressed at low levels in the spinal cord, ovary, lung, adrenal glands, heart, brain, testis and skeletal muscle.
DEVELOPMENTAL STAGE: Expressed at high levels in the fetal liver, lung and kidney.
INDUCTION: By nuclear factor-KB (NF-KB) and TNF. Induction by TNF depends upon activation of NF-KB.
SIMILARITY: Belongs to the TNFAIP8 family.

-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene           more ... click here to view the complete list

-  RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
  Highest median expression: 17.21 RPKM in Cells - EBV-transformed lymphocytes
Total median expression: 100.31 RPKM

View in GTEx track of Genome Browser    View at GTEx portal     View GTEx Body Map

+  Microarray Expression Data
  Press "+" in the title bar above to open this section.

-  mRNA Secondary Structure of 3' and 5' UTRs
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -100.20390-0.257 Picture PostScript Text
3' UTR -67.80362-0.187 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  InterPro Domains: Graphical view of domain structure
IPR008477 - DUF758

Pfam Domains:
PF05527 - Domain of unknown function (DUF758)

ModBase Predicted Comparative 3D Structure on O95379
The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
Genome BrowserGenome BrowserNo orthologGenome BrowserNo orthologNo ortholog
Gene Details     
Gene Sorter     
MGIRGD Ensembl  
Protein SequenceProtein Sequence Protein Sequence  
AlignmentAlignment Alignment  

-  Gene Ontology (GO) Annotations with Structured Vocabulary
  Molecular Function:
GO:0005515 protein binding
GO:0043027 cysteine-type endopeptidase inhibitor activity involved in apoptotic process

Biological Process:
GO:0006915 apoptotic process
GO:0042981 regulation of apoptotic process
GO:0043065 positive regulation of apoptotic process
GO:0043066 negative regulation of apoptotic process
GO:0043154 negative regulation of cysteine-type endopeptidase activity involved in apoptotic process

Cellular Component:
GO:0005654 nucleoplasm
GO:0005737 cytoplasm

-  Descriptions from all associated GenBank mRNAs
  LF211047 - JP 2014500723-A/18550: Polycomb-Associated Non-Coding RNAs.
MA446624 - JP 2018138019-A/18550: Polycomb-Associated Non-Coding RNAs.
AK097884 - Homo sapiens cDNA FLJ40565 fis, clone THYMU2004688, highly similar to Homo sapiens MDC-3.13 isoform 2 mRNA.
AK001931 - Homo sapiens cDNA FLJ11069 fis, clone PLACE1004930, highly similar to Homo sapiens tumor necrosis factor, alpha-induced protein 8 (TNFAIP8), mRNA.
AF070671 - Homo sapiens TNF-induced protein GG2-1 mRNA, complete cds.
AK301281 - Homo sapiens cDNA FLJ58699 complete cds, highly similar to Homo sapiens tumor necrosis factor, alpha-induced protein 8 (TNFAIP8), mRNA.
AK097284 - Homo sapiens cDNA FLJ39965 fis, clone SPLEN2027157, highly similar to Homo sapiens tumor necrosis factor, alpha-induced protein 8 (TNFAIP8), mRNA.
BC007014 - Homo sapiens tumor necrosis factor, alpha-induced protein 8, mRNA (cDNA clone MGC:12346 IMAGE:3930240), complete cds.
BC005352 - Homo sapiens tumor necrosis factor, alpha-induced protein 8, mRNA (cDNA clone MGC:12451 IMAGE:3997650), complete cds.
AF099935 - Homo sapiens MDC-3.13 isoform 2 mRNA, complete cds.
AK001850 - Homo sapiens cDNA FLJ10988 fis, clone PLACE1001920, highly similar to Homo sapiens tumor necrosis factor, alpha-induced protein 8 (TNFAIP8), mRNA.
AF099936 - Homo sapiens MDC-3.13 isoform 1 mRNA, complete cds.
CU675493 - Synthetic construct Homo sapiens gateway clone IMAGE:100020246 5' read TNFAIP8 mRNA.
HQ448379 - Synthetic construct Homo sapiens clone IMAGE:100071803; CCSB005463_03 tumor necrosis factor, alpha-induced protein 8 (TNFAIP8) gene, encodes complete protein.
KJ898553 - Synthetic construct Homo sapiens clone ccsbBroadEn_07947 TNFAIP8 gene, encodes complete protein.
KJ904700 - Synthetic construct Homo sapiens clone ccsbBroadEn_14094 TNFAIP8 gene, encodes complete protein.
CR457137 - Homo sapiens full open reading frame cDNA clone RZPDo834H127D for gene TNFAIP8, tumor necrosis factor, alpha-induced protein 8; complete cds, incl. stopcodon.
AF098933 - Homo sapiens head and neck tumor and metastasis related protein mRNA, partial cds.
JD330564 - Sequence 311588 from Patent EP1572962.
JD093001 - Sequence 74025 from Patent EP1572962.
LF343482 - JP 2014500723-A/150985: Polycomb-Associated Non-Coding RNAs.
MA579059 - JP 2018138019-A/150985: Polycomb-Associated Non-Coding RNAs.
JD184327 - Sequence 165351 from Patent EP1572962.
JD183295 - Sequence 164319 from Patent EP1572962.
JD553730 - Sequence 534754 from Patent EP1572962.
JD549261 - Sequence 530285 from Patent EP1572962.

-  Biochemical and Signaling Pathways
  Reactome (by CSHL, EBI, and GO)

Protein O95379 (Reactome details) participates in the following event(s):

R-HSA-8874470 TNFAIP8 proteins transfer PI(4,5)P2, PI(3,4,5)P3 from cytosolic vesicles to plasma membrane
R-HSA-1483255 PI Metabolism
R-HSA-1483257 Phospholipid metabolism
R-HSA-556833 Metabolism of lipids
R-HSA-1430728 Metabolism

-  Other Names for This Gene
  Alternate Gene Symbols: B3KMH1, B3KMI2, NM_001286814, O95379, Q9P1Q1, Q9UER5, Q9UP47, TFIP8_HUMAN, uc011cwf.1, uc011cwf.2, uc011cwf.3, uc011cwf.4
UCSC ID: uc011cwf.4
RefSeq Accession: NM_001286814
Protein: O95379 (aka TFIP8_HUMAN)
CCDS: CCDS68933.1

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.