Human Gene TNFAIP8 (ENST00000513374.1) Description and Page Index
  Description: Homo sapiens TNF alpha induced protein 8 (TNFAIP8), transcript variant 4, mRNA. (from RefSeq NM_001286814)
Gencode Transcript: ENST00000513374.1
Gencode Gene: ENSG00000145779.8
Transcript (Including UTRs)
   Position: hg38 chr5:119,333,175-119,393,743 Size: 60,569 Total Exon Count: 2 Strand: +
Coding Region
   Position: hg38 chr5:119,333,565-119,393,381 Size: 59,817 Coding Exon Count: 2 

Page IndexSequence and LinksUniProtKB CommentsCTDRNA-Seq ExpressionMicroarray Expression
RNA StructureProtein StructureOther SpeciesGO AnnotationsmRNA DescriptionsPathways
Other NamesMethods
Data last updated: 2019-09-04

-  Sequence and Links to Tools and Databases
 
Genomic Sequence (chr5:119,333,175-119,393,743)mRNA (may differ from genome)Protein (210 aa)
Gene SorterGenome BrowserOther Species FASTAGene interactionsTable SchemaBioGPS
CGAPEnsemblEntrez GeneExonPrimerGeneCardsHGNC
HPRDLynxMGIneXtProtOMIMPubMed
ReactomeStanford SOURCEUniProtKBWikipedia

-  Comments and Description Text from UniProtKB
  ID: TFIP8_HUMAN
DESCRIPTION: RecName: Full=Tumor necrosis factor alpha-induced protein 8; Short=TNF alpha-induced protein 8; AltName: Full=Head and neck tumor and metastasis-related protein; AltName: Full=MDC-3.13; AltName: Full=NF-kappa-B-inducible DED-containing protein; Short=NDED; AltName: Full=SCC-S2; AltName: Full=TNF-induced protein GG2-1;
FUNCTION: Acts as a negative mediator of apoptosis and may play a role in tumor progression. Suppresses the TNF-mediated apoptosis by inhibiting caspase-8 activity but not the processing of procaspase-8, subsequently resulting in inhibition of BID cleavage and caspase-3 activation.
SUBCELLULAR LOCATION: Cytoplasm.
TISSUE SPECIFICITY: Expressed at high levels in the spleen, lymph node, thymus, thyroid, bone marrow and placenta. Expressed at high levels both in various tumor tissues, unstimulated and cytokine- activated cultured cells. Expressed at low levels in the spinal cord, ovary, lung, adrenal glands, heart, brain, testis and skeletal muscle.
DEVELOPMENTAL STAGE: Expressed at high levels in the fetal liver, lung and kidney.
INDUCTION: By nuclear factor-KB (NF-KB) and TNF. Induction by TNF depends upon activation of NF-KB.
SIMILARITY: Belongs to the TNFAIP8 family.

-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene           more ... click here to view the complete list

-  RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
  Highest median expression: 17.21 RPKM in Cells - EBV-transformed lymphocytes
Total median expression: 100.31 RPKM



View in GTEx track of Genome Browser    View at GTEx portal     View GTEx Body Map

+  Microarray Expression Data
  Press "+" in the title bar above to open this section.

-  mRNA Secondary Structure of 3' and 5' UTRs
 
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -100.20390-0.257 Picture PostScript Text
3' UTR -67.80362-0.187 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  InterPro Domains: Graphical view of domain structure
IPR008477 - DUF758

Pfam Domains:
PF05527 - Domain of unknown function (DUF758)

ModBase Predicted Comparative 3D Structure on O95379
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-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
Genome BrowserGenome BrowserNo orthologGenome BrowserNo orthologNo ortholog
Gene Details     
Gene Sorter     
MGIRGD Ensembl  
Protein SequenceProtein Sequence Protein Sequence  
AlignmentAlignment Alignment  

-  Gene Ontology (GO) Annotations with Structured Vocabulary
  Molecular Function:
GO:0005515 protein binding
GO:0043027 cysteine-type endopeptidase inhibitor activity involved in apoptotic process

Biological Process:
GO:0006915 apoptotic process
GO:0042981 regulation of apoptotic process
GO:0043065 positive regulation of apoptotic process
GO:0043066 negative regulation of apoptotic process
GO:0043154 negative regulation of cysteine-type endopeptidase activity involved in apoptotic process

Cellular Component:
GO:0005654 nucleoplasm
GO:0005737 cytoplasm


-  Descriptions from all associated GenBank mRNAs
  LF211047 - JP 2014500723-A/18550: Polycomb-Associated Non-Coding RNAs.
MA446624 - JP 2018138019-A/18550: Polycomb-Associated Non-Coding RNAs.
AK097884 - Homo sapiens cDNA FLJ40565 fis, clone THYMU2004688, highly similar to Homo sapiens MDC-3.13 isoform 2 mRNA.
AK001931 - Homo sapiens cDNA FLJ11069 fis, clone PLACE1004930, highly similar to Homo sapiens tumor necrosis factor, alpha-induced protein 8 (TNFAIP8), mRNA.
AF070671 - Homo sapiens TNF-induced protein GG2-1 mRNA, complete cds.
AK301281 - Homo sapiens cDNA FLJ58699 complete cds, highly similar to Homo sapiens tumor necrosis factor, alpha-induced protein 8 (TNFAIP8), mRNA.
AK097284 - Homo sapiens cDNA FLJ39965 fis, clone SPLEN2027157, highly similar to Homo sapiens tumor necrosis factor, alpha-induced protein 8 (TNFAIP8), mRNA.
BC007014 - Homo sapiens tumor necrosis factor, alpha-induced protein 8, mRNA (cDNA clone MGC:12346 IMAGE:3930240), complete cds.
BC005352 - Homo sapiens tumor necrosis factor, alpha-induced protein 8, mRNA (cDNA clone MGC:12451 IMAGE:3997650), complete cds.
AF099935 - Homo sapiens MDC-3.13 isoform 2 mRNA, complete cds.
AK001850 - Homo sapiens cDNA FLJ10988 fis, clone PLACE1001920, highly similar to Homo sapiens tumor necrosis factor, alpha-induced protein 8 (TNFAIP8), mRNA.
AF099936 - Homo sapiens MDC-3.13 isoform 1 mRNA, complete cds.
CU675493 - Synthetic construct Homo sapiens gateway clone IMAGE:100020246 5' read TNFAIP8 mRNA.
HQ448379 - Synthetic construct Homo sapiens clone IMAGE:100071803; CCSB005463_03 tumor necrosis factor, alpha-induced protein 8 (TNFAIP8) gene, encodes complete protein.
KJ898553 - Synthetic construct Homo sapiens clone ccsbBroadEn_07947 TNFAIP8 gene, encodes complete protein.
KJ904700 - Synthetic construct Homo sapiens clone ccsbBroadEn_14094 TNFAIP8 gene, encodes complete protein.
CR457137 - Homo sapiens full open reading frame cDNA clone RZPDo834H127D for gene TNFAIP8, tumor necrosis factor, alpha-induced protein 8; complete cds, incl. stopcodon.
AF098933 - Homo sapiens head and neck tumor and metastasis related protein mRNA, partial cds.
JD330564 - Sequence 311588 from Patent EP1572962.
JD093001 - Sequence 74025 from Patent EP1572962.
LF343482 - JP 2014500723-A/150985: Polycomb-Associated Non-Coding RNAs.
MA579059 - JP 2018138019-A/150985: Polycomb-Associated Non-Coding RNAs.
JD184327 - Sequence 165351 from Patent EP1572962.
JD183295 - Sequence 164319 from Patent EP1572962.
JD553730 - Sequence 534754 from Patent EP1572962.
JD549261 - Sequence 530285 from Patent EP1572962.

-  Biochemical and Signaling Pathways
  Reactome (by CSHL, EBI, and GO)

Protein O95379 (Reactome details) participates in the following event(s):

R-HSA-8874470 TNFAIP8 proteins transfer PI(4,5)P2, PI(3,4,5)P3 from cytosolic vesicles to plasma membrane
R-HSA-1483255 PI Metabolism
R-HSA-1483257 Phospholipid metabolism
R-HSA-556833 Metabolism of lipids
R-HSA-1430728 Metabolism

-  Other Names for This Gene
  Alternate Gene Symbols: B3KMH1, B3KMI2, NM_001286814, O95379, Q9P1Q1, Q9UER5, Q9UP47, TFIP8_HUMAN, uc011cwf.1, uc011cwf.2, uc011cwf.3, uc011cwf.4
UCSC ID: uc011cwf.4
RefSeq Accession: NM_001286814
Protein: O95379 (aka TFIP8_HUMAN)
CCDS: CCDS68933.1

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.