Human Gene EXOSC9 (ENST00000512454.5) Description and Page Index
  Description: exosome component 9 (from HGNC EXOSC9)
RefSeq Summary (NM_005033): This gene encodes a component of the human exosome, a exoribonuclease complex which processes and degrades RNA in the nucleus and cytoplasm. This component may play a role in mRNA degradation and the polymyositis/scleroderma autoantigen complex. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2011].
Gencode Transcript: ENST00000512454.5
Gencode Gene: ENSG00000123737.12
Transcript (Including UTRs)
   Position: hg38 chr4:121,801,593-121,816,911 Size: 15,319 Total Exon Count: 11 Strand: +
Coding Region
   Position: hg38 chr4:121,801,809-121,816,856 Size: 15,048 Coding Exon Count: 11 

Page IndexSequence and LinksMalaCardsCTDRNA-Seq ExpressionMicroarray Expression
RNA StructureProtein StructureOther SpeciesGO AnnotationsmRNA DescriptionsPathways
Other NamesMethods
Data last updated: 2019-09-04

-  Sequence and Links to Tools and Databases
Genomic Sequence (chr4:121,801,593-121,816,911)mRNA (may differ from genome)Protein (423 aa)
Gene SorterGenome BrowserOther Species FASTAGene interactionsTable SchemaBioGPS
MGIPubMedStanford SOURCEUniProtKBWikipedia

-  MalaCards Disease Associations
  MalaCards Gene Search: EXOSC9
Diseases sorted by gene-association score: polymyositis (16), osteogenesis imperfecta, type xii (5)

-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene           more ... click here to view the complete list

-  RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
  Highest median expression: 30.07 RPKM in Cells - EBV-transformed lymphocytes
Total median expression: 401.81 RPKM

View in GTEx track of Genome Browser    View at GTEx portal     View GTEx Body Map

+  Microarray Expression Data
  Press "+" in the title bar above to open this section.

-  mRNA Secondary Structure of 3' and 5' UTRs
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -48.00216-0.222 Picture PostScript Text
3' UTR -11.0055-0.200 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  InterPro Domains: Graphical view of domain structure
IPR001247 - ExoRNase_PH_dom1
IPR015847 - ExoRNase_PH_dom2
IPR020568 - Ribosomal_S5_D2-typ_fold

Pfam Domains:
PF01138 - 3' exoribonuclease family, domain 1
PF03725 - 3' exoribonuclease family, domain 2

ModBase Predicted Comparative 3D Structure on D6RIY6
The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
Genome BrowserGenome BrowserNo orthologNo orthologNo orthologNo ortholog
Gene Details     
Gene Sorter     
Protein SequenceProtein Sequence    

-  Gene Ontology (GO) Annotations with Structured Vocabulary
  Biological Process:
GO:0006396 RNA processing

Cellular Component:
GO:0000178 exosome (RNase complex)
GO:0005730 nucleolus

-  Descriptions from all associated GenBank mRNAs
  AK301967 - Homo sapiens cDNA FLJ55260 complete cds, highly similar to Exosome complex exonuclease RRP45 (EC 3.1.13.-).
AJ505989 - Homo sapiens mRNA for polymyositis/scleroderma autoantigen 1 (PMSCL1 gene), splice variant 1.
AJ517294 - Homo sapiens mRNA for polymyositis/scleroderma autoantigen 1 (PMSCL1 gene), splice variant 2.
BX649106 - Homo sapiens mRNA; cDNA DKFZp686L2298 (from clone DKFZp686L2298).
BC142978 - Homo sapiens exosome component 9, mRNA (cDNA clone MGC:167080 IMAGE:8860413), complete cds.
AK307548 - Homo sapiens cDNA, FLJ97496.
BC012371 - Homo sapiens exosome component 9, mRNA (cDNA clone IMAGE:3879930), with apparent retained intron.
BC140038 - Synthetic construct Homo sapiens clone IMAGE:100000916, MGC:167226 exosome component 9 (EXOSC9) mRNA, encodes complete protein.
BC140039 - Synthetic construct Homo sapiens clone IMAGE:100013650, MGC:167227 exosome component 9 (EXOSC9) mRNA, encodes complete protein.
KJ897350 - Synthetic construct Homo sapiens clone ccsbBroadEn_06744 EXOSC9 gene, encodes complete protein.
M58460 - Human 75-kD autoantigen (PM-Sc1) mRNA, complete cds.
JD501064 - Sequence 482088 from Patent EP1572962.
JD211413 - Sequence 192437 from Patent EP1572962.
JD123113 - Sequence 104137 from Patent EP1572962.
JD114282 - Sequence 95306 from Patent EP1572962.
JD046435 - Sequence 27459 from Patent EP1572962.
U09215 - Human PM-Scl-75 autoantigen (PM-sc1) mRNA, complete cds.
AK310894 - Homo sapiens cDNA, FLJ17936.

-  Biochemical and Signaling Pathways
  KEGG - Kyoto Encyclopedia of Genes and Genomes
hsa03018 - RNA degradation

-  Other Names for This Gene
  Alternate Gene Symbols: D6RIY6, D6RIY6_HUMAN, hCG_38830, M58460, uc003ieb.1, uc003ieb.2, uc003ieb.3, uc003ieb.4
UCSC ID: uc003ieb.4
RefSeq Accession: NM_005033
Protein: D6RIY6 CCDS: CCDS3722.2

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.