Human Gene EXOSC9 (ENST00000512454.5) Description and Page Index
  Description: exosome component 9 (from HGNC EXOSC9)
RefSeq Summary (NM_005033): This gene encodes a component of the human exosome, a exoribonuclease complex which processes and degrades RNA in the nucleus and cytoplasm. This component may play a role in mRNA degradation and the polymyositis/scleroderma autoantigen complex. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2011].
Gencode Transcript: ENST00000512454.5
Gencode Gene: ENSG00000123737.12
Transcript (Including UTRs)
   Position: hg38 chr4:121,801,593-121,816,911 Size: 15,319 Total Exon Count: 11 Strand: +
Coding Region
   Position: hg38 chr4:121,801,809-121,816,856 Size: 15,048 Coding Exon Count: 11 

Page IndexSequence and LinksMalaCardsCTDRNA-Seq ExpressionMicroarray Expression
RNA StructureProtein StructureOther SpeciesGO AnnotationsmRNA DescriptionsPathways
Other NamesMethods
Data last updated: 2019-09-04

-  Sequence and Links to Tools and Databases
 
Genomic Sequence (chr4:121,801,593-121,816,911)mRNA (may differ from genome)Protein (423 aa)
Gene SorterGenome BrowserOther Species FASTAGene interactionsTable SchemaBioGPS
CGAPEnsemblExonPrimerGeneCardsHGNCLynx
MGIPubMedStanford SOURCEUniProtKBWikipedia

-  MalaCards Disease Associations
  MalaCards Gene Search: EXOSC9
Diseases sorted by gene-association score: polymyositis (16), osteogenesis imperfecta, type xii (5)

-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene           more ... click here to view the complete list

-  RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
  Highest median expression: 30.07 RPKM in Cells - EBV-transformed lymphocytes
Total median expression: 401.81 RPKM



View in GTEx track of Genome Browser    View at GTEx portal     View GTEx Body Map

+  Microarray Expression Data
  Press "+" in the title bar above to open this section.

-  mRNA Secondary Structure of 3' and 5' UTRs
 
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -48.00216-0.222 Picture PostScript Text
3' UTR -11.0055-0.200 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  InterPro Domains: Graphical view of domain structure
IPR001247 - ExoRNase_PH_dom1
IPR015847 - ExoRNase_PH_dom2
IPR020568 - Ribosomal_S5_D2-typ_fold

Pfam Domains:
PF01138 - 3' exoribonuclease family, domain 1
PF03725 - 3' exoribonuclease family, domain 2

ModBase Predicted Comparative 3D Structure on D6RIY6
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-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
Genome BrowserGenome BrowserNo orthologNo orthologNo orthologNo ortholog
Gene Details     
Gene Sorter     
MGIRGD    
Protein SequenceProtein Sequence    
AlignmentAlignment    

-  Gene Ontology (GO) Annotations with Structured Vocabulary
  Biological Process:
GO:0006396 RNA processing

Cellular Component:
GO:0000178 exosome (RNase complex)
GO:0005730 nucleolus


-  Descriptions from all associated GenBank mRNAs
  AK301967 - Homo sapiens cDNA FLJ55260 complete cds, highly similar to Exosome complex exonuclease RRP45 (EC 3.1.13.-).
AJ505989 - Homo sapiens mRNA for polymyositis/scleroderma autoantigen 1 (PMSCL1 gene), splice variant 1.
AJ517294 - Homo sapiens mRNA for polymyositis/scleroderma autoantigen 1 (PMSCL1 gene), splice variant 2.
BX649106 - Homo sapiens mRNA; cDNA DKFZp686L2298 (from clone DKFZp686L2298).
BC142978 - Homo sapiens exosome component 9, mRNA (cDNA clone MGC:167080 IMAGE:8860413), complete cds.
AK307548 - Homo sapiens cDNA, FLJ97496.
BC012371 - Homo sapiens exosome component 9, mRNA (cDNA clone IMAGE:3879930), with apparent retained intron.
BC140038 - Synthetic construct Homo sapiens clone IMAGE:100000916, MGC:167226 exosome component 9 (EXOSC9) mRNA, encodes complete protein.
BC140039 - Synthetic construct Homo sapiens clone IMAGE:100013650, MGC:167227 exosome component 9 (EXOSC9) mRNA, encodes complete protein.
KJ897350 - Synthetic construct Homo sapiens clone ccsbBroadEn_06744 EXOSC9 gene, encodes complete protein.
M58460 - Human 75-kD autoantigen (PM-Sc1) mRNA, complete cds.
JD501064 - Sequence 482088 from Patent EP1572962.
JD211413 - Sequence 192437 from Patent EP1572962.
JD123113 - Sequence 104137 from Patent EP1572962.
JD114282 - Sequence 95306 from Patent EP1572962.
JD046435 - Sequence 27459 from Patent EP1572962.
U09215 - Human PM-Scl-75 autoantigen (PM-sc1) mRNA, complete cds.
AK310894 - Homo sapiens cDNA, FLJ17936.

-  Biochemical and Signaling Pathways
  KEGG - Kyoto Encyclopedia of Genes and Genomes
hsa03018 - RNA degradation

-  Other Names for This Gene
  Alternate Gene Symbols: D6RIY6, D6RIY6_HUMAN, hCG_38830, M58460, uc003ieb.1, uc003ieb.2, uc003ieb.3, uc003ieb.4
UCSC ID: uc003ieb.4
RefSeq Accession: NM_005033
Protein: D6RIY6 CCDS: CCDS3722.2

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.