Human Gene EXOSC9 (ENST00000512454.5) Description and Page Index
Description: exosome component 9 (from HGNC EXOSC9) RefSeq Summary (NM_005033): This gene encodes a component of the human exosome, a exoribonuclease complex which processes and degrades RNA in the nucleus and cytoplasm. This component may play a role in mRNA degradation and the polymyositis/scleroderma autoantigen complex. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2011]. Gencode Transcript: ENST00000512454.5 Gencode Gene: ENSG00000123737.12 Transcript (Including UTRs) Position: hg38 chr4:121,801,593-121,816,911 Size: 15,319 Total Exon Count: 11 Strand: + Coding Region Position: hg38 chr4:121,801,809-121,816,856 Size: 15,048 Coding Exon Count: 11
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on D6RIY6
The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.
Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.