Human Gene HOMER1 (ENST00000508576.5) Description and Page Index
Description: Homo sapiens homer scaffold protein 1 (HOMER1), transcript variant 3, mRNA. (from RefSeq NM_001277078) RefSeq Summary (NM_001277078): This gene encodes a member of the homer family of dendritic proteins. Members of this family regulate group 1 metabotrophic glutamate receptor function. [provided by RefSeq, Jul 2008]. Gencode Transcript: ENST00000508576.5 Gencode Gene: ENSG00000152413.15 Transcript (Including UTRs) Position: hg38 chr5:79,375,930-79,512,794 Size: 136,865 Total Exon Count: 6 Strand: - Coding Region Position: hg38 chr5:79,376,191-79,512,774 Size: 136,584 Coding Exon Count: 6
ID:HOME1_HUMAN DESCRIPTION: RecName: Full=Homer protein homolog 1; Short=Homer-1; FUNCTION: Postsynaptic density scaffolding protein. Binds and cross-links cytoplasmic regions of GRM1, GRM5, ITPR1, DNM3, RYR1, RYR2, SHANK1 and SHANK3. By physically linking GRM1 and GRM5 with ER-associated ITPR1 receptors, it aids the coupling of surface receptors to intracellular calcium release. May also couple GRM1 to PI3 kinase through its interaction with AGAP2. Isoform 1 regulates the trafficking and surface expression of GRM5. Isoform 3 acts as a natural dominant negative, in dynamic competition with constitutively expressed isoform 1 to regulate synaptic metabotropic glutamate function. Isoform 3, may be involved in the structural changes that occur at synapses during long-lasting neuronal plasticity and development. SUBUNIT: Interacts with IFT57 (By similarity). Interacts with OPHN1 (By similarity). Isoform 1 encodes a coiled-coil structure that mediates homo- and heteromultimerization. SUBCELLULAR LOCATION: Cytoplasm (By similarity). Cell junction, synapse, postsynaptic cell membrane, postsynaptic density (By similarity). Cell junction, synapse (By similarity). Note=Postsynaptic density of neuronal cells. Isoform 1 inhibits surface expression of GRM5 causing it to be retained in the endoplasmic reticulum (By similarity). DOMAIN: The WH1 domain interacts with the PPXXF motif in GRM1, GRM5, RYR1, RYR2, ITPR1, SHANK 1 and SHANK3. SIMILARITY: Belongs to the Homer family. SIMILARITY: Contains 1 WH1 domain.
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on Q86YM7
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
Biological Process: GO:0003009 skeletal muscle contraction GO:0007206 phospholipase C-activating G-protein coupled glutamate receptor signaling pathway GO:0007268 chemical synaptic transmission GO:0009967 positive regulation of signal transduction GO:0048148 behavioral response to cocaine GO:0048741 skeletal muscle fiber development GO:0048875 chemical homeostasis within a tissue GO:0051592 response to calcium ion GO:0051928 positive regulation of calcium ion transport GO:0090279 regulation of calcium ion import GO:2001256 regulation of store-operated calcium entry GO:2001257 regulation of cation channel activity