Human Gene DCLK2 (ENST00000506325.5) Description and Page Index
Description: Protein kinase with a significantly reduced C(a2+)/CAM affinity and dependence compared to other members of the CaMK family. May play a role in the down-regulation of CRE-dependent gene activation probably by phosphorylation of the CREB coactivator CRTC2/TORC2 and the resulting retention of TORC2 in the cytoplasm (By similarity). (from UniProt Q8N568) RefSeq Summary (NM_001040260): This gene encodes a member of the protein kinase superfamily and the doublecortin family. The protein encoded by this gene contains two N-terminal doublecortin domains, which bind microtubules and regulate microtubule polymerization, a C-terminal serine/threonine protein kinase domain, which shows substantial homology to Ca2+/calmodulin-dependent protein kinase, and a serine/proline-rich domain in between the doublecortin and the protein kinase domains, which mediates multiple protein-protein interactions. The microtubule-polymerizing activity of the encoded protein is independent of its protein kinase activity. Mouse studies show that the DCX gene, another family member, and this gene share function in the establishment of hippocampal organization and that their absence results in a severe epileptic phenotype and lethality, as described in human patients with lissencephaly. Multiple alternatively spliced transcript variants have been identified. [provided by RefSeq, Sep 2010]. Gencode Transcript: ENST00000506325.5 Gencode Gene: ENSG00000170390.16 Transcript (Including UTRs) Position: hg38 chr4:150,079,028-150,256,247 Size: 177,220 Total Exon Count: 16 Strand: + Coding Region Position: hg38 chr4:150,079,028-150,256,247 Size: 177,220 Coding Exon Count: 16
ID:DCLK2_HUMAN DESCRIPTION: RecName: Full=Serine/threonine-protein kinase DCLK2; EC=22.214.171.124; AltName: Full=CaMK-like CREB regulatory kinase 2; Short=CL2; Short=CLICK-II; Short=CLICK2; AltName: Full=Doublecortin domain-containing protein 3B; AltName: Full=Doublecortin-like and CAM kinase-like 2; AltName: Full=Doublecortin-like kinase 2; FUNCTION: Protein kinase with a significantly reduced C(a2+)/CAM affinity and dependence compared to other members of the CaMK family. May play a role in the down-regulation of CRE-dependent gene activation probably by phosphorylation of the CREB coactivator CRTC2/TORC2 and the resulting retention of TORC2 in the cytoplasm (By similarity). CATALYTIC ACTIVITY: ATP + a protein = ADP + a phosphoprotein. SUBUNIT: Binds to and stabilizes microtubules (By similarity). Interacts with MAPK8IP1/JIP-1, MAPK8IP2/JIP-2, MAPK9/JNK2, PPP1R9B/NEURABIN-2 and actin (By similarity). SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton. Note=Colocalizes with microtubules (By similarity). TISSUE SPECIFICITY: Expressed in the brain, heart and eyes. DEVELOPMENTAL STAGE: Expressed in fetal brain, and, to a lower extent, in fetal kidney. DOMAIN: The doublecortin domains are involved in the colocalization with microtubules (By similarity). PTM: Autophosphorylated (By similarity). SIMILARITY: Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. CaMK subfamily. SIMILARITY: Contains 2 doublecortin domains. SIMILARITY: Contains 1 protein kinase domain. SEQUENCE CAUTION: Sequence=BAD92418.1; Type=Erroneous initiation; Note=Translation N-terminally shortened;
ModBase Predicted Comparative 3D Structure on Q8N568
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.