Human Gene DNAH12 (ENST00000495027.5) Description and Page Index
  Description: Homo sapiens dynein axonemal heavy chain 12 (DNAH12), transcript variant 4, mRNA. (from RefSeq NM_001366028)
Gencode Transcript: ENST00000495027.5
Gencode Gene: ENSG00000174844.14
Transcript (Including UTRs)
   Position: hg38 chr3:57,293,699-57,544,344 Size: 250,646 Total Exon Count: 74 Strand: -
Coding Region
   Position: hg38 chr3:57,293,781-57,542,870 Size: 249,090 Coding Exon Count: 73 

Page IndexSequence and LinksUniProtKB CommentsMalaCardsCTDRNA-Seq Expression
Microarray ExpressionRNA StructureProtein StructureOther SpeciesGO AnnotationsmRNA Descriptions
Other NamesMethods
Data last updated: 2019-09-04

-  Sequence and Links to Tools and Databases
 
Genomic Sequence (chr3:57,293,699-57,544,344)mRNA (may differ from genome)Protein (3960 aa)
Gene SorterGenome BrowserOther Species FASTAGene interactionsTable SchemaBioGPS
CGAPEnsemblEntrez GeneExonPrimerGeneCardsHGNC
LynxMGIOMIMPubMedStanford SOURCEUniProtKB

-  Comments and Description Text from UniProtKB
  ID: E9PG32_HUMAN
DESCRIPTION: SubName: Full=Dynein heavy chain 12, axonemal; Flags: Fragment;
CAUTION: The sequence shown here is derived from an Ensembl automatic analysis pipeline and should be considered as preliminary data.

-  MalaCards Disease Associations
  MalaCards Gene Search: DNAH12
Diseases sorted by gene-association score: rectum adenocarcinoma (9), papillary craniopharyngioma (8), adamantinous craniopharyngioma (7)

-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene

-  RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
  Highest median expression: 3.60 RPKM in Testis
Total median expression: 6.44 RPKM



View in GTEx track of Genome Browser    View at GTEx portal     View GTEx Body Map

+  Microarray Expression Data
  Press "+" in the title bar above to open this section.

-  mRNA Secondary Structure of 3' and 5' UTRs
 
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -59.20181-0.327 Picture PostScript Text
3' UTR -3.7282-0.045 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  InterPro Domains: Graphical view of domain structure
IPR003593 - AAA+_ATPase
IPR011704 - ATPase_dyneun-rel_AAA
IPR026983 - DHC_fam
IPR024317 - Dynein_heavy_chain_D4_dom
IPR013602 - Dynein_heavy_dom-2

Pfam Domains:
PF07728 - AAA domain (dynein-related subfamily)
PF12780 - P-loop containing dynein motor region D4
PF08393 - Dynein heavy chain, N-terminal region 2

ModBase Predicted Comparative 3D Structure on E9PG32
FrontTopSide
The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
Genome BrowserGenome BrowserNo orthologNo orthologNo orthologNo ortholog
Gene Details     
Gene Sorter     
MGIRGDEnsembl   
Protein SequenceProtein Sequence    
AlignmentAlignment    

-  Gene Ontology (GO) Annotations with Structured Vocabulary
  Molecular Function:
GO:0003777 microtubule motor activity
GO:0005524 ATP binding
GO:0016887 ATPase activity

Biological Process:
GO:0007018 microtubule-based movement

Cellular Component:
GO:0030286 dynein complex


-  Descriptions from all associated GenBank mRNAs
  AK126276 - Homo sapiens cDNA FLJ44290 fis, clone TRACH2019473.
AK097746 - Homo sapiens cDNA FLJ40427 fis, clone TESTI2039113.
AK128592 - Homo sapiens cDNA FLJ46751 fis, clone TRACH3022960, weakly similar to Dynein beta chain, ciliary.
JD062577 - Sequence 43601 from Patent EP1572962.
BC043164 - Homo sapiens cDNA clone IMAGE:5286816.
Z83802 - H.sapiens mRNA for axonemal dynein heavy chain (partial, ID hdhc3).
U53532 - Human cytoplasmic dynein 3 heavy chain mRNA, partial cds.

-  Other Names for This Gene
  Alternate Gene Symbols: E9PG32, E9PG32_HUMAN, NM_001366028, uc032rop.1, uc032rop.2
UCSC ID: uc032rop.2
RefSeq Accession: NM_001366028
Protein: E9PG32

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.