Human Gene ADCY5 (ENST00000491190.5) Description and Page Index
Description: Belongs to the adenylyl cyclase class-4/guanylyl cyclase family. (from UniProt B3KWA8) RefSeq Summary (NM_001199642): This gene encodes a member of the membrane-bound adenylyl cyclase enzymes. Adenylyl cyclases mediate G protein-coupled receptor signaling through the synthesis of the second messenger cAMP. Activity of the encoded protein is stimulated by the Gs alpha subunit of G protein-coupled receptors and is inhibited by protein kinase A, calcium and Gi alpha subunits. Single nucleotide polymorphisms in this gene may be associated with low birth weight and type 2 diabetes. Alternatively spliced transcript variants that encode different isoforms have been observed for this gene. [provided by RefSeq, Dec 2010]. Gencode Transcript: ENST00000491190.5 Gencode Gene: ENSG00000173175.14 Transcript (Including UTRs) Position: hg38 chr3:123,283,944-123,419,209 Size: 135,266 Total Exon Count: 23 Strand: - Coding Region Position: hg38 chr3:123,284,608-123,367,937 Size: 83,330 Coding Exon Count: 22
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
Pfam Domains: PF06327 - Domain of Unknown Function (DUF1053) PF00211 - Adenylate and Guanylate cyclase catalytic domain
ModBase Predicted Comparative 3D Structure on B3KWA8
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.