Human Gene RUSC1 (ENST00000490373.5) Description and Page Index
  Description: Contains 1 SH3 domain. (from UniProt Q68CX2)
Gencode Transcript: ENST00000490373.5
Gencode Gene: ENSG00000160753.16
Transcript (Including UTRs)
   Position: hg38 chr1:155,324,522-155,330,730 Size: 6,209 Total Exon Count: 8 Strand: +
Coding Region
   Position: hg38 chr1:155,326,792-155,330,571 Size: 3,780 Coding Exon Count: 3 

Page IndexSequence and LinksUniProtKB CommentsCTDRNA-Seq ExpressionMicroarray Expression
RNA StructureProtein StructureOther SpeciesGO AnnotationsmRNA DescriptionsOther Names
Methods
Data last updated: 2019-09-04

-  Sequence and Links to Tools and Databases
 
Genomic Sequence (chr1:155,324,522-155,330,730)mRNA (may differ from genome)Protein (211 aa)
Gene SorterGenome BrowserOther Species FASTAGene interactionsTable SchemaBioGPS
CGAPEnsemblExonPrimerGeneCardsHGNCLynx
MGIPubMedStanford SOURCEUniProtKB

-  Comments and Description Text from UniProtKB
  ID: Q68CX2_HUMAN
DESCRIPTION: SubName: Full=Putative uncharacterized protein DKFZp761A1822;
SIMILARITY: Contains 1 SH3 domain.

-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene

-  RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
  Highest median expression: 43.30 RPKM in Brain - Cerebellum
Total median expression: 604.85 RPKM



View in GTEx track of Genome Browser    View at GTEx portal     View GTEx Body Map

+  Microarray Expression Data
  Press "+" in the title bar above to open this section.

-  mRNA Secondary Structure of 3' and 5' UTRs
 
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -414.50905-0.458 Picture PostScript Text
3' UTR -29.30159-0.184 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  InterPro Domains: Graphical view of domain structure
IPR001452 - SH3_domain

Pfam Domains:
PF00018 - SH3 domain

ModBase Predicted Comparative 3D Structure on Q68CX2
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The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
Genome BrowserGenome BrowserNo orthologNo orthologNo orthologNo ortholog
Gene Details     
Gene Sorter     
MGIRGD    
Protein SequenceProtein Sequence    
AlignmentAlignment    

-  Gene Ontology (GO) Annotations with Structured Vocabulary
  Cellular Component:
GO:0005829 cytosol


-  Descriptions from all associated GenBank mRNAs
  AK125378 - Homo sapiens cDNA FLJ43388 fis, clone OCBBF2007028, highly similar to RUN and SH3 domain-containing protein 1.
BC025680 - Homo sapiens RUN and SH3 domain containing 1, mRNA (cDNA clone IMAGE:5204626), with apparent retained intron.
AK055451 - Homo sapiens cDNA FLJ30889 fis, clone FEBRA2005114, highly similar to Homo sapiens mRNA for NESCA.
AK314559 - Homo sapiens cDNA, FLJ95383, highly similar to Homo sapiens RUN and SH3 domain containing 1 (RUSC1), mRNA.
CR749671 - Homo sapiens mRNA; cDNA DKFZp761A1822 (from clone DKFZp761A1822).
BC052277 - Homo sapiens RUN and SH3 domain containing 1, mRNA (cDNA clone IMAGE:4548018), complete cds.
AK298730 - Homo sapiens cDNA FLJ55745 complete cds, highly similar to RUN and SH3 domain-containing protein 1.
AK093777 - Homo sapiens cDNA FLJ36458 fis, clone THYMU2014599, highly similar to Nesca protein.
AX748300 - Sequence 1825 from Patent EP1308459.
BC001045 - Homo sapiens RUN and SH3 domain containing 1, mRNA (cDNA clone IMAGE:3505458), complete cds.
AK307736 - Homo sapiens cDNA, FLJ97684.
AK074485 - Homo sapiens cDNA FLJ90004 fis, clone HEMBA1000006.
AB026894 - Homo sapiens mRNA for NESCA, complete cds.
JD318158 - Sequence 299182 from Patent EP1572962.
AK074982 - Homo sapiens cDNA FLJ90501 fis, clone NT2RP3004067, highly similar to RUN and SH3 domain-containing protein 1.
BC028055 - Homo sapiens, Similar to nesca protein, clone IMAGE:5108891, mRNA.
BC004293 - Homo sapiens, clone IMAGE:3621946, mRNA, partial cds.
BX640612 - Homo sapiens mRNA; cDNA DKFZp686F12178 (from clone DKFZp686F12178).
CU674524 - Synthetic construct Homo sapiens gateway clone IMAGE:100018280 5' read RUSC1 mRNA.
AB590126 - Synthetic construct DNA, clone: pFN21AE1122, Homo sapiens RUSC1 gene for RUN and SH3 domain containing 1, without stop codon, in Flexi system.
DQ895385 - Synthetic construct Homo sapiens clone IMAGE:100009845; FLH183888.01L; RZPDo839H10141D RUN and SH3 domain containing 1 (RUSC1) gene, encodes complete protein.
KJ893417 - Synthetic construct Homo sapiens clone ccsbBroadEn_02811 RUSC1 gene, encodes complete protein.
DQ893622 - Synthetic construct clone IMAGE:100006252; FLH183892.01X; RZPDo839H10142D RUN and SH3 domain containing 1 (RUSC1) gene, encodes complete protein.
AL080083 - Homo sapiens mRNA; cDNA DKFZp564G1762 (from clone DKFZp564G1762); partial cds.

-  Other Names for This Gene
  Alternate Gene Symbols: BC028055, DKFZp761A1822, Q68CX2, Q68CX2_HUMAN, uc001fkn.1, uc001fkn.2, uc001fkn.3, uc001fkn.4
UCSC ID: uc001fkn.4
RefSeq Accession: NM_001278230
Protein: Q68CX2

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.