Human Gene HYI (ENST00000486909.1) Description and Page Index
  Description: The sequence shown here is derived from an Ensembl automatic analysis pipeline and should be considered as preliminary data. (from UniProt E7EWH8)
RefSeq Summary (NM_001190880): This gene encodes a putative hydroxypyruvate isomerase, which likely catalyzes the conversion of hydroxypyruvate to 2-hydroxy-3-oxopropanoate, and may be involved in carbohydrate transport and metabolism. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Aug 2011].
Gencode Transcript: ENST00000486909.1
Gencode Gene: ENSG00000178922.16
Transcript (Including UTRs)
   Position: hg38 chr1:43,451,320-43,453,848 Size: 2,529 Total Exon Count: 7 Strand: -
Coding Region
   Position: hg38 chr1:43,451,339-43,453,793 Size: 2,455 Coding Exon Count: 7 

Page IndexSequence and LinksUniProtKB CommentsCTDRNA-Seq ExpressionMicroarray Expression
RNA StructureProtein StructureOther SpeciesGO AnnotationsmRNA DescriptionsPathways
Other NamesMethods
Data last updated: 2019-09-04

-  Sequence and Links to Tools and Databases
Genomic Sequence (chr1:43,451,320-43,453,848)mRNA (may differ from genome)Protein (276 aa)
Gene SorterGenome BrowserOther Species FASTAGene interactionsTable SchemaBioGPS
MGIPubMedStanford SOURCEUniProtKB

-  Comments and Description Text from UniProtKB
DESCRIPTION: SubName: Full=Putative hydroxypyruvate isomerase;
CAUTION: The sequence shown here is derived from an Ensembl automatic analysis pipeline and should be considered as preliminary data.

-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene           more ... click here to view the complete list

-  RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
  Highest median expression: 20.67 RPKM in Ovary
Total median expression: 519.27 RPKM

View in GTEx track of Genome Browser    View at GTEx portal     View GTEx Body Map

+  Microarray Expression Data
  Press "+" in the title bar above to open this section.

-  mRNA Secondary Structure of 3' and 5' UTRs
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -17.8055-0.324 Picture PostScript Text
3' UTR -4.3019-0.226 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  InterPro Domains: Graphical view of domain structure
IPR026040 - HyI-like
IPR013022 - Xyl_isomerase-like_TIM-brl
IPR012307 - Xyl_isomerase_TIM-brl

Pfam Domains:
PF01261 - Xylose isomerase-like TIM barrel

ModBase Predicted Comparative 3D Structure on E7EWH8
The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
Genome BrowserGenome BrowserNo orthologNo orthologNo orthologNo ortholog
Gene Details     
Gene Sorter     
Protein SequenceProtein Sequence    

-  Gene Ontology (GO) Annotations with Structured Vocabulary
  Molecular Function:
GO:0008903 hydroxypyruvate isomerase activity
GO:0016853 isomerase activity

-  Descriptions from all associated GenBank mRNAs
  BC006140 - Homo sapiens hydroxypyruvate isomerase homolog (E. coli), mRNA (cDNA clone MGC:13085 IMAGE:3928690), complete cds.
BC019041 - Homo sapiens hydroxypyruvate isomerase homolog (E. coli), mRNA (cDNA clone MGC:20767 IMAGE:4586546), complete cds.
AY037165 - Homo sapiens hypothetical protein SB156 mRNA, complete cds.
AY775560 - Homo sapiens endothelial cell apoptosis protein E-CE1 mRNA, complete cds.
AF284750 - Homo sapiens HT036-ISO (HT036-ISO) mRNA, complete cds.
AF284751 - Homo sapiens HT036 (HT036) mRNA, complete cds.
AK096244 - Homo sapiens cDNA FLJ38925 fis, clone NT2NE2012243, highly similar to Homo sapiens hydroxypyruvate isomerase homolog (E. coli) (HYI), mRNA.
JF911821 - Homo sapiens hydroxypyruvate isomerase mRNA, complete cds.
HQ447696 - Synthetic construct Homo sapiens clone IMAGE:100071024; CCSB013449_01 hydroxypyruvate isomerase homolog (E. coli) (HYI) gene, encodes complete protein.
KJ903338 - Synthetic construct Homo sapiens clone ccsbBroadEn_12732 HYI gene, encodes complete protein.
CU675267 - Synthetic construct Homo sapiens gateway clone IMAGE:100022419 5' read HYI mRNA.
KJ903337 - Synthetic construct Homo sapiens clone ccsbBroadEn_12731 HYI gene, encodes complete protein.
JD437861 - Sequence 418885 from Patent EP1572962.
JD458351 - Sequence 439375 from Patent EP1572962.

-  Biochemical and Signaling Pathways
  KEGG - Kyoto Encyclopedia of Genes and Genomes
hsa00630 - Glyoxylate and dicarboxylate metabolism
hsa01100 - Metabolic pathways

-  Other Names for This Gene
  Alternate Gene Symbols: AY037165, E7EWH8, E7EWH8_HUMAN, uc057fnz.1
UCSC ID: uc057fnz.1
RefSeq Accession: NM_001190880
Protein: E7EWH8

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.