Human Gene FSBP (ENST00000481490.3) Description and Page Index
  Description: Homo sapiens fibrinogen silencer binding protein (FSBP), mRNA. (from RefSeq NM_001256141)
Gencode Transcript: ENST00000481490.3
Gencode Gene: ENSG00000265817.3
Transcript (Including UTRs)
   Position: hg38 chr8:94,427,716-94,436,944 Size: 9,229 Total Exon Count: 2 Strand: -
Coding Region
   Position: hg38 chr8:94,432,131-94,436,868 Size: 4,738 Coding Exon Count: 2 

Page IndexSequence and LinksUniProtKB CommentsRNA-Seq ExpressionMicroarray ExpressionRNA Structure
Protein StructureOther SpeciesGO AnnotationsmRNA DescriptionsOther NamesMethods
Data last updated: 2019-09-04

-  Sequence and Links to Tools and Databases
Genomic Sequence (chr8:94,427,716-94,436,944)mRNA (may differ from genome)Protein (299 aa)
Gene SorterGenome BrowserOther Species FASTAGene interactionsTable SchemaBioGPS
CGAPEnsemblEntrez GeneExonPrimerGeneCardsHGNC
LynxMGIneXtProtOMIMPubMedStanford SOURCE

-  Comments and Description Text from UniProtKB
DESCRIPTION: RecName: Full=Fibrinogen silencer-binding protein;
FUNCTION: Transcriptional repressor that down-regulates the expression of the fibrinogen gamma chain. Represses transcription of GSK3B gene promoter via its interaction with APBA1.
SUBUNIT: Interacts with APBA1 (via PDZ 1 and 2 domains).
TISSUE SPECIFICITY: Expressed in multiple tissues including brain.
MISCELLANEOUS: Intragenic, in the second intron of RAB54B gene.
WEB RESOURCE: Name=SeattleSNPs; URL="";

-  RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
  Highest median expression: 9.23 RPKM in Cells - EBV-transformed lymphocytes
Total median expression: 40.43 RPKM

View in GTEx track of Genome Browser    View at GTEx portal     View GTEx Body Map

+  Microarray Expression Data
  Press "+" in the title bar above to open this section.

-  mRNA Secondary Structure of 3' and 5' UTRs
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -15.5076-0.204 Picture PostScript Text
3' UTR -1057.904415-0.240 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  ModBase Predicted Comparative 3D Structure on O95073
The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
Genome BrowserGenome BrowserNo orthologGenome BrowserNo orthologNo ortholog
Gene Details     
Gene Sorter     
Protein SequenceProtein Sequence Protein Sequence  
AlignmentAlignment Alignment  

-  Gene Ontology (GO) Annotations with Structured Vocabulary
  Molecular Function:
GO:0005515 protein binding
GO:0042802 identical protein binding

Biological Process:
GO:0006351 transcription, DNA-templated
GO:0006355 regulation of transcription, DNA-templated

Cellular Component:
GO:0005634 nucleus

-  Descriptions from all associated GenBank mRNAs
  AK307516 - Homo sapiens cDNA, FLJ97464.
BC020668 - Homo sapiens cDNA clone IMAGE:4773245.
AK074272 - Homo sapiens cDNA FLJ23692 fis, clone HEP10227.
JD492164 - Sequence 473188 from Patent EP1572962.
JD546566 - Sequence 527590 from Patent EP1572962.
JD160999 - Sequence 142023 from Patent EP1572962.
BC033710 - Homo sapiens RAD54 homolog B (S. cerevisiae), mRNA (cDNA clone IMAGE:3914364), complete cds.
AF007866 - Homo sapiens fibrinogen silencer binding protein mRNA, complete cds.
JD184573 - Sequence 165597 from Patent EP1572962.
KJ902372 - Synthetic construct Homo sapiens clone ccsbBroadEn_11766 RAD54B gene, encodes complete protein.

-  Other Names for This Gene
  Alternate Gene Symbols: FSBP_HUMAN, NM_001256141, O95073, Q8N4S5, uc003ygm.1, uc003ygm.2, uc003ygm.3, uc003ygm.4, uc003ygm.5
UCSC ID: uc003ygm.5
RefSeq Accession: NM_001256141
Protein: O95073 (aka FSBP_HUMAN)
CCDS: CCDS59106.1

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.