Human Gene FSBP (ENST00000481490.3) Description and Page Index
  Description: Homo sapiens fibrinogen silencer binding protein (FSBP), mRNA. (from RefSeq NM_001256141)
Gencode Transcript: ENST00000481490.3
Gencode Gene: ENSG00000265817.3
Transcript (Including UTRs)
   Position: hg38 chr8:94,427,716-94,436,944 Size: 9,229 Total Exon Count: 2 Strand: -
Coding Region
   Position: hg38 chr8:94,432,131-94,436,868 Size: 4,738 Coding Exon Count: 2 

Page IndexSequence and LinksUniProtKB CommentsRNA-Seq ExpressionMicroarray ExpressionRNA Structure
Protein StructureOther SpeciesGO AnnotationsmRNA DescriptionsOther NamesMethods
Data last updated: 2019-09-04

-  Sequence and Links to Tools and Databases
 
Genomic Sequence (chr8:94,427,716-94,436,944)mRNA (may differ from genome)Protein (299 aa)
Gene SorterGenome BrowserOther Species FASTAGene interactionsTable SchemaBioGPS
CGAPEnsemblEntrez GeneExonPrimerGeneCardsHGNC
LynxMGIneXtProtOMIMPubMedStanford SOURCE
UniProtKB

-  Comments and Description Text from UniProtKB
  ID: FSBP_HUMAN
DESCRIPTION: RecName: Full=Fibrinogen silencer-binding protein;
FUNCTION: Transcriptional repressor that down-regulates the expression of the fibrinogen gamma chain. Represses transcription of GSK3B gene promoter via its interaction with APBA1.
SUBUNIT: Interacts with APBA1 (via PDZ 1 and 2 domains).
SUBCELLULAR LOCATION: Nucleus.
TISSUE SPECIFICITY: Expressed in multiple tissues including brain.
MISCELLANEOUS: Intragenic, in the second intron of RAB54B gene.
WEB RESOURCE: Name=SeattleSNPs; URL="http://pga.gs.washington.edu/data/fsbp/";

-  RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
  Highest median expression: 9.23 RPKM in Cells - EBV-transformed lymphocytes
Total median expression: 40.43 RPKM



View in GTEx track of Genome Browser    View at GTEx portal     View GTEx Body Map

+  Microarray Expression Data
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-  mRNA Secondary Structure of 3' and 5' UTRs
 
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -15.5076-0.204 Picture PostScript Text
3' UTR -1057.904415-0.240 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  ModBase Predicted Comparative 3D Structure on O95073
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-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
Genome BrowserGenome BrowserNo orthologGenome BrowserNo orthologNo ortholog
Gene Details     
Gene Sorter     
MGIRGDEnsemblEnsembl  
Protein SequenceProtein Sequence Protein Sequence  
AlignmentAlignment Alignment  

-  Gene Ontology (GO) Annotations with Structured Vocabulary
  Molecular Function:
GO:0005515 protein binding
GO:0042802 identical protein binding

Biological Process:
GO:0006351 transcription, DNA-templated
GO:0006355 regulation of transcription, DNA-templated

Cellular Component:
GO:0005634 nucleus


-  Descriptions from all associated GenBank mRNAs
  AK307516 - Homo sapiens cDNA, FLJ97464.
BC020668 - Homo sapiens cDNA clone IMAGE:4773245.
AK074272 - Homo sapiens cDNA FLJ23692 fis, clone HEP10227.
JD492164 - Sequence 473188 from Patent EP1572962.
JD546566 - Sequence 527590 from Patent EP1572962.
JD160999 - Sequence 142023 from Patent EP1572962.
BC033710 - Homo sapiens RAD54 homolog B (S. cerevisiae), mRNA (cDNA clone IMAGE:3914364), complete cds.
AF007866 - Homo sapiens fibrinogen silencer binding protein mRNA, complete cds.
JD184573 - Sequence 165597 from Patent EP1572962.
KJ902372 - Synthetic construct Homo sapiens clone ccsbBroadEn_11766 RAD54B gene, encodes complete protein.

-  Other Names for This Gene
  Alternate Gene Symbols: FSBP_HUMAN, NM_001256141, O95073, Q8N4S5, uc003ygm.1, uc003ygm.2, uc003ygm.3, uc003ygm.4, uc003ygm.5
UCSC ID: uc003ygm.5
RefSeq Accession: NM_001256141
Protein: O95073 (aka FSBP_HUMAN)
CCDS: CCDS59106.1

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.