Human Gene MRPS14 (ENST00000476371.1) Description and Page Index
  Description: Homo sapiens mitochondrial ribosomal protein S14 (MRPS14), transcript variant 2, non-coding RNA. (from RefSeq NR_037606)
RefSeq Summary (NM_022100): Mammalian mitochondrial ribosomal proteins are encoded by nuclear genes and help in protein synthesis within the mitochondrion. Mitochondrial ribosomes (mitoribosomes) consist of a small 28S subunit and a large 39S subunit. They have an estimated 75% protein to rRNA composition compared to prokaryotic ribosomes, where this ratio is reversed. Another difference between mammalian mitoribosomes and prokaryotic ribosomes is that the latter contain a 5S rRNA. Among different species, the proteins comprising the mitoribosome differ greatly in sequence, and sometimes in biochemical properties, which prevents easy recognition by sequence homology. This gene encodes a 28S subunit protein that belongs to the ribosomal protein S14P family. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Nov 2010].
Gencode Transcript: ENST00000476371.1
Gencode Gene: ENSG00000120333.4
Transcript (Including UTRs)
   Position: hg38 chr1:175,012,958-175,023,425 Size: 10,468 Total Exon Count: 3 Strand: -
Coding Region
   Position: hg38 chr1:175,014,669-175,023,408 Size: 8,740 Coding Exon Count: 3 

Page IndexSequence and LinksUniProtKB CommentsCTDRNA-Seq ExpressionMicroarray Expression
RNA StructureProtein StructureOther SpeciesGO AnnotationsmRNA DescriptionsPathways
Other NamesMethods
Data last updated: 2019-09-04

-  Sequence and Links to Tools and Databases
Genomic Sequence (chr1:175,012,958-175,023,425)mRNA (may differ from genome)Protein (128 aa)
Gene SorterGenome BrowserOther Species FASTAGene interactionsTable SchemaBioGPS
CGAPEnsemblEntrez GeneExonPrimerGeneCardsHGNC
ReactomeStanford SOURCEUniProtKB

-  Comments and Description Text from UniProtKB
DESCRIPTION: RecName: Full=28S ribosomal protein S14, mitochondrial; Short=MRP-S14; Short=S14mt;
SUBUNIT: Component of the mitochondrial ribosome small subunit (28S) which comprises a 12S rRNA and about 30 distinct proteins (By similarity).
INTERACTION: Q9NY93:DDX56; NbExp=1; IntAct=EBI-1045956, EBI-372376;
SIMILARITY: Belongs to the ribosomal protein S14P family.

-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene           more ... click here to view the complete list

-  RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
  Highest median expression: 15.93 RPKM in Brain - Spinal cord (cervical c-1)
Total median expression: 601.78 RPKM

View in GTEx track of Genome Browser    View at GTEx portal     View GTEx Body Map

+  Microarray Expression Data
  Press "+" in the title bar above to open this section.

-  mRNA Secondary Structure of 3' and 5' UTRs
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -1.5017-0.088 Picture PostScript Text
3' UTR -410.401711-0.240 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  InterPro Domains: Graphical view of domain structure
IPR001209 - Ribosomal_S14

Pfam Domains:
PF00253 - Ribosomal protein S14p/S29e

ModBase Predicted Comparative 3D Structure on O60783
The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
Genome BrowserGenome BrowserNo orthologGenome BrowserGenome BrowserGenome Browser
Gene Details    Gene Details
Gene Sorter    Gene Sorter
Protein SequenceProtein Sequence Protein SequenceProtein SequenceProtein Sequence
AlignmentAlignment AlignmentAlignmentAlignment

-  Gene Ontology (GO) Annotations with Structured Vocabulary
  Molecular Function:
GO:0003723 RNA binding
GO:0003735 structural constituent of ribosome

Biological Process:
GO:0006412 translation
GO:0070125 mitochondrial translational elongation
GO:0070126 mitochondrial translational termination

Cellular Component:
GO:0005622 intracellular
GO:0005739 mitochondrion
GO:0005743 mitochondrial inner membrane
GO:0005761 mitochondrial ribosome
GO:0005763 mitochondrial small ribosomal subunit
GO:0005840 ribosome

-  Descriptions from all associated GenBank mRNAs
  LF383649 - JP 2014500723-A/191152: Polycomb-Associated Non-Coding RNAs.
MA619226 - JP 2018138019-A/191152: Polycomb-Associated Non-Coding RNAs.
AL049705 - Human gene from PAC 262D12, chromosome 1.
AK310915 - Homo sapiens cDNA, FLJ17957.
JD475482 - Sequence 456506 from Patent EP1572962.
JD447532 - Sequence 428556 from Patent EP1572962.
JD360454 - Sequence 341478 from Patent EP1572962.
LF320230 - JP 2014500723-A/127733: Polycomb-Associated Non-Coding RNAs.
MA555807 - JP 2018138019-A/127733: Polycomb-Associated Non-Coding RNAs.
JD553072 - Sequence 534096 from Patent EP1572962.
LF318789 - JP 2014500723-A/126292: Polycomb-Associated Non-Coding RNAs.
MA554366 - JP 2018138019-A/126292: Polycomb-Associated Non-Coding RNAs.
LF205268 - JP 2014500723-A/12771: Polycomb-Associated Non-Coding RNAs.
MA440845 - JP 2018138019-A/12771: Polycomb-Associated Non-Coding RNAs.
JD283986 - Sequence 265010 from Patent EP1572962.
BC009788 - Homo sapiens mitochondrial ribosomal protein S14, mRNA (cDNA clone MGC:13571 IMAGE:4132323), complete cds.
JD410937 - Sequence 391961 from Patent EP1572962.
LF320229 - JP 2014500723-A/127732: Polycomb-Associated Non-Coding RNAs.
MA555806 - JP 2018138019-A/127732: Polycomb-Associated Non-Coding RNAs.
JD381999 - Sequence 363023 from Patent EP1572962.
JD425194 - Sequence 406218 from Patent EP1572962.
AK311759 - Homo sapiens cDNA, FLJ92019, highly similar to Homo sapiens mitochondrial ribosomal protein S14 (MRPS14), nuclear gene encoding mitochondrial protein, mRNA.
KJ894515 - Synthetic construct Homo sapiens clone ccsbBroadEn_03909 MRPS14 gene, encodes complete protein.
LF320226 - JP 2014500723-A/127729: Polycomb-Associated Non-Coding RNAs.
MA555803 - JP 2018138019-A/127729: Polycomb-Associated Non-Coding RNAs.
LF318790 - JP 2014500723-A/126293: Polycomb-Associated Non-Coding RNAs.
MA554367 - JP 2018138019-A/126293: Polycomb-Associated Non-Coding RNAs.

-  Biochemical and Signaling Pathways
  Reactome (by CSHL, EBI, and GO)

Protein O60783 (Reactome details) participates in the following event(s):

R-HSA-5368279 MTIF3 binds 28S ribosomal subunit
R-HSA-5419273 Hydrolysis of GTP and dissociation of 28S and 39S subunits
R-HSA-5389849 28S subunit:MTIF3 binds MTIF2:GTP, mRNA, and formylMet-tRNA
R-HSA-5389839 39S subunit binds 28S subunit:mRNA:fMet-tRNA
R-HSA-5389848 TUFM:GTP:aminoacyl-tRNA binds 55S ribosome:mRNA:fMet-tRNA
R-HSA-5389857 Peptide transfer from P-site to A-site (peptide bond formation)
R-HSA-5389842 TUFM hydrolyzes GTP and TUFM:GDP dissociates from 55S ribosome
R-HSA-5419261 55S ribosome with peptidyl-tRNA in A site binds GFM1:GTP
R-HSA-5419281 MRRF binds 55S ribosome:mRNA:tRNA
R-HSA-5419279 Translocation of peptidyl-tRNA from A-site to P-site (and translocation of 55S ribosome by 3 bases along mRNA)
R-HSA-5419264 MTRF1L (MTRF1a) or ICT1 binds stop codon in 55S ribosome:mRNA:peptidyl-tRNA
R-HSA-5419277 GFM2:GTP binds 55S ribosome:mRNA:tRNA:MRRF releasing mRNA and tRNA
R-HSA-5368286 Mitochondrial translation initiation
R-HSA-5419276 Mitochondrial translation termination
R-HSA-5368287 Mitochondrial translation
R-HSA-5389840 Mitochondrial translation elongation
R-HSA-72766 Translation
R-HSA-392499 Metabolism of proteins

-  Other Names for This Gene
  Alternate Gene Symbols: NR_037606, O60783, Q5R358, RT14_HUMAN, uc001gkk.1, uc001gkk.2, uc001gkk.3, uc001gkk.4
UCSC ID: uc001gkk.4
RefSeq Accession: NM_022100
Protein: O60783 (aka RT14_HUMAN)
CCDS: CCDS1316.1

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.