Human Gene MRPS14 (ENST00000476371.1) Description and Page Index
Description: Homo sapiens mitochondrial ribosomal protein S14 (MRPS14), transcript variant 2, non-coding RNA. (from RefSeq NR_037606) RefSeq Summary (NM_022100): Mammalian mitochondrial ribosomal proteins are encoded by nuclear genes and help in protein synthesis within the mitochondrion. Mitochondrial ribosomes (mitoribosomes) consist of a small 28S subunit and a large 39S subunit. They have an estimated 75% protein to rRNA composition compared to prokaryotic ribosomes, where this ratio is reversed. Another difference between mammalian mitoribosomes and prokaryotic ribosomes is that the latter contain a 5S rRNA. Among different species, the proteins comprising the mitoribosome differ greatly in sequence, and sometimes in biochemical properties, which prevents easy recognition by sequence homology. This gene encodes a 28S subunit protein that belongs to the ribosomal protein S14P family. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Nov 2010]. Gencode Transcript: ENST00000476371.1 Gencode Gene: ENSG00000120333.4 Transcript (Including UTRs) Position: hg38 chr1:175,012,958-175,023,425 Size: 10,468 Total Exon Count: 3 Strand: - Coding Region Position: hg38 chr1:175,014,669-175,023,408 Size: 8,740 Coding Exon Count: 3
ID:RT14_HUMAN DESCRIPTION: RecName: Full=28S ribosomal protein S14, mitochondrial; Short=MRP-S14; Short=S14mt; SUBUNIT: Component of the mitochondrial ribosome small subunit (28S) which comprises a 12S rRNA and about 30 distinct proteins (By similarity). INTERACTION: Q9NY93:DDX56; NbExp=1; IntAct=EBI-1045956, EBI-372376; SUBCELLULAR LOCATION: Mitochondrion. SIMILARITY: Belongs to the ribosomal protein S14P family.
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
Pfam Domains: PF00253 - Ribosomal protein S14p/S29e
ModBase Predicted Comparative 3D Structure on O60783
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.