Human Gene RPL23A (ENST00000472628.1) Description and Page Index
  Description: ribosomal protein L23a (from HGNC RPL23A)
RefSeq Summary (NM_000984): Ribosomes, the organelles that catalyze protein synthesis, consist of a small 40S subunit and a large 60S subunit. Together these subunits are composed of 4 RNA species and approximately 80 structurally distinct proteins. This gene encodes a ribosomal protein that is a component of the 60S subunit. The protein belongs to the L23P family of ribosomal proteins. It is located in the cytoplasm. The protein may be one of the target molecules involved in mediating growth inhibition by interferon. In yeast, the corresponding protein binds to a specific site on the 26S rRNA. This gene is co-transcribed with the U42A, U42B, U101A, and U101B small nucleolar RNA genes, which are located in its third, first, second, and fourth introns, respectively. As is typical for genes encoding ribosomal proteins, there are multiple processed pseudogenes of this gene dispersed through the genome. [provided by RefSeq, Jul 2008]. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: SRR5189658.26679.1, SRR5189661.13134.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1965299, SAMEA1966682 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## MANE Ensembl match :: ENST00000422514.7/ ENSP00000389103.2 RefSeq Select criteria :: based on single protein-coding transcript ##RefSeq-Attributes-END##
Gencode Transcript: ENST00000472628.1
Gencode Gene: ENSG00000198242.14
Transcript (Including UTRs)
   Position: hg38 chr17:28,720,569-28,723,936 Size: 3,368 Total Exon Count: 4 Strand: +
Coding Region
   Position: hg38 chr17:28,722,772-28,723,881 Size: 1,110 Coding Exon Count: 3 

Page IndexSequence and LinksMalaCardsCTDRNA-Seq ExpressionMicroarray Expression
RNA StructureOther SpeciesmRNA DescriptionsPathwaysOther NamesMethods
Data last updated: 2019-09-04

-  Sequence and Links to Tools and Databases
 
Genomic Sequence (chr17:28,720,569-28,723,936)mRNA (may differ from genome)Protein (70 aa)
Gene SorterGenome BrowserOther Species FASTAGene interactionsTable SchemaBioGPS
CGAPEnsemblExonPrimerGeneCardsHGNCLynx
MGIPubMedStanford SOURCEUniProtKBWikipedia

-  MalaCards Disease Associations
  MalaCards Gene Search: RPL23A
Diseases sorted by gene-association score: diamond-blackfan anemia (2)

-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene           more ... click here to view the complete list

-  RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
  Highest median expression: 316.07 RPKM in Cells - EBV-transformed lymphocytes
Total median expression: 5784.83 RPKM



View in GTEx track of Genome Browser    View at GTEx portal     View GTEx Body Map

+  Microarray Expression Data
  Press "+" in the title bar above to open this section.

-  mRNA Secondary Structure of 3' and 5' UTRs
 
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -100.70371-0.271 Picture PostScript Text
3' UTR -3.7055-0.067 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
Genome BrowserNo orthologNo orthologNo orthologNo orthologNo ortholog
Gene Details     
Gene Sorter     
MGI     
Protein Sequence     
Alignment     

-  Descriptions from all associated GenBank mRNAs
  LF209210 - JP 2014500723-A/16713: Polycomb-Associated Non-Coding RNAs.
MA444787 - JP 2018138019-A/16713: Polycomb-Associated Non-Coding RNAs.
U43701 - Human ribosomal protein L23a mRNA, complete cds.
AK312123 - Homo sapiens cDNA, FLJ92405, Homo sapiens ribosomal protein L23a (RPL23A), mRNA.
AK130965 - Homo sapiens cDNA FLJ27455 fis, clone UBA04121, highly similar to 60S ribosomal protein L23a.
BC058041 - Homo sapiens ribosomal protein L23a, mRNA (cDNA clone MGC:61848 IMAGE:6716166), complete cds.
U37230 - Human ribosomal protein L23a mRNA, complete cds.
BC070191 - Homo sapiens cDNA clone IMAGE:6715798, partial cds.
BC014459 - Homo sapiens ribosomal protein L23a, mRNA (cDNA clone MGC:23063 IMAGE:4872948), complete cds.
KJ897490 - Synthetic construct Homo sapiens clone ccsbBroadEn_06884 RPL23A gene, encodes complete protein.
U02032 - Human ribosomal protein L23a mRNA, partial cds.
AB527711 - Synthetic construct DNA, clone: pF1KB6848, Homo sapiens RPL23A gene for ribosomal protein L23a, without stop codon, in Flexi system.
DQ570698 - Homo sapiens piRNA piR-30810, complete sequence.
LF326827 - JP 2014500723-A/134330: Polycomb-Associated Non-Coding RNAs.
MA562404 - JP 2018138019-A/134330: Polycomb-Associated Non-Coding RNAs.
L13799 - Homo sapiens (clone 01) liver expressed protein mRNA, 3'end.
LF333881 - JP 2014500723-A/141384: Polycomb-Associated Non-Coding RNAs.
MA569458 - JP 2018138019-A/141384: Polycomb-Associated Non-Coding RNAs.
LF321874 - JP 2014500723-A/129377: Polycomb-Associated Non-Coding RNAs.
MA557451 - JP 2018138019-A/129377: Polycomb-Associated Non-Coding RNAs.
LF323198 - JP 2014500723-A/130701: Polycomb-Associated Non-Coding RNAs.
MA558775 - JP 2018138019-A/130701: Polycomb-Associated Non-Coding RNAs.
LF326826 - JP 2014500723-A/134329: Polycomb-Associated Non-Coding RNAs.
MA562403 - JP 2018138019-A/134329: Polycomb-Associated Non-Coding RNAs.
LF335288 - JP 2014500723-A/142791: Polycomb-Associated Non-Coding RNAs.
MA570865 - JP 2018138019-A/142791: Polycomb-Associated Non-Coding RNAs.
LF331933 - JP 2014500723-A/139436: Polycomb-Associated Non-Coding RNAs.
MA567510 - JP 2018138019-A/139436: Polycomb-Associated Non-Coding RNAs.
LF321876 - JP 2014500723-A/129379: Polycomb-Associated Non-Coding RNAs.
MA557453 - JP 2018138019-A/129379: Polycomb-Associated Non-Coding RNAs.
LF326825 - JP 2014500723-A/134328: Polycomb-Associated Non-Coding RNAs.
LF335286 - JP 2014500723-A/142789: Polycomb-Associated Non-Coding RNAs.
MA562402 - JP 2018138019-A/134328: Polycomb-Associated Non-Coding RNAs.
MA570863 - JP 2018138019-A/142789: Polycomb-Associated Non-Coding RNAs.
JD207484 - Sequence 188508 from Patent EP1572962.
LF372783 - JP 2014500723-A/180286: Polycomb-Associated Non-Coding RNAs.
MA608360 - JP 2018138019-A/180286: Polycomb-Associated Non-Coding RNAs.
LF321878 - JP 2014500723-A/129381: Polycomb-Associated Non-Coding RNAs.
MA557455 - JP 2018138019-A/129381: Polycomb-Associated Non-Coding RNAs.
LF335284 - JP 2014500723-A/142787: Polycomb-Associated Non-Coding RNAs.
MA570861 - JP 2018138019-A/142787: Polycomb-Associated Non-Coding RNAs.
LF326824 - JP 2014500723-A/134327: Polycomb-Associated Non-Coding RNAs.
MA562401 - JP 2018138019-A/134327: Polycomb-Associated Non-Coding RNAs.
LF358211 - JP 2014500723-A/165714: Polycomb-Associated Non-Coding RNAs.
MA593788 - JP 2018138019-A/165714: Polycomb-Associated Non-Coding RNAs.

-  Biochemical and Signaling Pathways
  KEGG - Kyoto Encyclopedia of Genes and Genomes
hsa03010 - Ribosome

-  Other Names for This Gene
  Alternate Gene Symbols: K7EMA7, U37230, uc060ddq.1
UCSC ID: uc060ddq.1
RefSeq Accession: NM_000984

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.