Human Gene PTPRE (ENST00000471218.5) Description and Page Index
  Description: protein tyrosine phosphatase, receptor type E (from HGNC PTPRE)
RefSeq Summary (NM_001316677): The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. Several alternatively spliced transcript variants of this gene have been reported, at least two of which encode a receptor-type PTP that possesses a short extracellular domain, a single transmembrane region, and two tandem intracytoplasmic catalytic domains; another one encodes a PTP that contains a distinct hydrophilic N-terminus, and thus represents a nonreceptor-type isoform of this PTP. Studies of the similar gene in mice suggested the regulatory roles of this PTP in RAS related signal transduction pathways, cytokine-induced SATA signaling, as well as the activation of voltage-gated K+ channels. [provided by RefSeq, Oct 2015].
Gencode Transcript: ENST00000471218.5
Gencode Gene: ENSG00000132334.16
Transcript (Including UTRs)
   Position: hg38 chr10:127,987,344-128,056,170 Size: 68,827 Total Exon Count: 6 Strand: +
Coding Region
   Position: hg38 chr10:128,040,882-128,056,157 Size: 15,276 Coding Exon Count: 5 

Page IndexSequence and LinksCTDRNA-Seq ExpressionMicroarray ExpressionRNA Structure
Other SpeciesmRNA DescriptionsOther NamesMethods
Data last updated: 2019-09-04

-  Sequence and Links to Tools and Databases
Genomic Sequence (chr10:127,987,344-128,056,170)mRNA (may differ from genome)Protein (149 aa)
Gene SorterGenome BrowserOther Species FASTAGene interactionsTable SchemaBioGPS
MGIPubMedStanford SOURCEUniProtKBWikipedia

-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene           more ... click here to view the complete list

-  RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
  Highest median expression: 18.55 RPKM in Whole Blood
Total median expression: 188.07 RPKM

View in GTEx track of Genome Browser    View at GTEx portal     View GTEx Body Map

+  Microarray Expression Data
  Press "+" in the title bar above to open this section.

-  mRNA Secondary Structure of 3' and 5' UTRs
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -18.6059-0.315 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
Genome BrowserGenome BrowserNo orthologNo orthologNo orthologNo ortholog
Gene Details     
Gene Sorter     
Protein SequenceProtein Sequence    

-  Descriptions from all associated GenBank mRNAs
  BC031078 - Homo sapiens cDNA clone IMAGE:5295028, containing frame-shift errors.
AF406557 - Homo sapiens PTPRE (PTPRE) mRNA, partial cds.
BC050062 - Homo sapiens protein tyrosine phosphatase, receptor type, E, mRNA (cDNA clone MGC:48280 IMAGE:5274802), complete cds.
X54134 - Human HPTP epsilon mRNA for protein tyrosine phosphatase epsilon.
AK291828 - Homo sapiens cDNA FLJ76898 complete cds, highly similar to Homo sapiens protein tyrosine phosphatase, receptor type, E (PTPRE), transcript variant 1, mRNA.
AK300613 - Homo sapiens cDNA FLJ58245 complete cds, highly similar to Receptor-type tyrosine-protein phosphatase epsilon precursor (EC
AK299498 - Homo sapiens cDNA FLJ57799 complete cds, highly similar to Receptor-type tyrosine-protein phosphatase epsilon precursor (EC
AB590774 - Synthetic construct DNA, clone: pFN21AB9968, Homo sapiens PTPRE gene for protein tyrosine phosphatase, receptor type, E, without stop codon, in Flexi system.
CU690634 - Synthetic construct Homo sapiens gateway clone IMAGE:100021005 5' read PTPRE mRNA.
JF432831 - Synthetic construct Homo sapiens clone IMAGE:100074150 protein tyrosine phosphatase, receptor type, E (PTPRE) gene, encodes complete protein.
KJ897423 - Synthetic construct Homo sapiens clone ccsbBroadEn_06817 PTPRE gene, encodes complete protein.
BX648180 - Homo sapiens mRNA; cDNA DKFZp686K099 (from clone DKFZp686K099).
BC071573 - Homo sapiens cDNA clone IMAGE:5269075, containing frame-shift errors.
AK290414 - Homo sapiens cDNA FLJ75634 complete cds, highly similar to Homo sapiens protein tyrosine phosphatase, receptor type, E (PTPRE), transcript variant 2, mRNA.
AJ430580 - Homo sapiens mRNA for tyrosine phosphatase epsilon PD1 (PTPRE gene).
AJ315969 - Homo sapiens mRNA for tyrosine phosphatase epsilon (PTPRE gene), cytoplasmic splice variant.
AK056111 - Homo sapiens cDNA FLJ31549 fis, clone NT2RI2001030, highly similar to PROTEIN-TYROSINE PHOSPHATASE EPSILON PRECURSOR (EC
U36623 - Homo sapiens protein tyrosine phosphatase epsilon cytoplasmic isoform (PTPRE) mRNA, partial cds.

-  Other Names for This Gene
  Alternate Gene Symbols: AK291828, S4R3B0, uc057wur.1
UCSC ID: uc057wur.1
RefSeq Accession: NM_001316677

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.