Human Gene EXD3 (ENST00000465160.2) Description and Page Index
  Description: Homo sapiens exonuclease 3'-5' domain containing 3 (EXD3), transcript variant 4, non-coding RNA. (from RefSeq NR_104599)
Gencode Transcript: ENST00000465160.2
Gencode Gene: ENSG00000187609.16
Transcript (Including UTRs)
   Position: hg38 chr9:137,391,802-137,423,162 Size: 31,361 Total Exon Count: 3 Strand: -
Coding Region
   Position: hg38 chr9:137,393,120-137,395,357 Size: 2,238 Coding Exon Count: 2 

Page IndexSequence and LinksUniProtKB CommentsCTDRNA-Seq ExpressionMicroarray Expression
RNA StructureProtein StructureOther SpeciesGO AnnotationsmRNA DescriptionsOther Names
Data last updated: 2019-09-04

-  Sequence and Links to Tools and Databases
Genomic Sequence (chr9:137,391,802-137,423,162)mRNA (may differ from genome)Protein (56 aa)
Gene SorterGenome BrowserOther Species FASTAGene interactionsTable SchemaBioGPS
CGAPEnsemblEntrez GeneExonPrimerGeneCardsHGNC
LynxMGImyGene2neXtProtPubMedStanford SOURCE

-  Comments and Description Text from UniProtKB
DESCRIPTION: RecName: Full=Probable exonuclease mut-7 homolog; EC=3.1.-.-; AltName: Full=Exonuclease 3'-5' domain-containing protein 3;
SIMILARITY: Belongs to the mut-7 family.
SIMILARITY: Contains 1 3'-5' exonuclease domain.
SEQUENCE CAUTION: Sequence=BAC04356.1; Type=Erroneous termination; Positions=759; Note=Translated as Ser;

-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene

-  RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
  Highest median expression: 7.62 RPKM in Prostate
Total median expression: 189.82 RPKM

View in GTEx track of Genome Browser    View at GTEx portal     View GTEx Body Map

+  Microarray Expression Data
  Press "+" in the title bar above to open this section.

-  mRNA Secondary Structure of 3' and 5' UTRs
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -43.6096-0.454 Picture PostScript Text
3' UTR -481.701318-0.365 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  InterPro Domains: Graphical view of domain structure
IPR002562 - 3'-5'_exonuclease_dom
IPR002782 - DUF82
IPR012337 - RNaseH-like_dom

Pfam Domains:
PF01612 - 3'-5' exonuclease
PF01927 - Mut7-C RNAse domain

ModBase Predicted Comparative 3D Structure on Q8N9H8
The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
No orthologNo orthologNo orthologNo orthologNo orthologNo ortholog

-  Gene Ontology (GO) Annotations with Structured Vocabulary
  Molecular Function:
GO:0003676 nucleic acid binding
GO:0004518 nuclease activity
GO:0004527 exonuclease activity
GO:0008408 3'-5' exonuclease activity
GO:0016787 hydrolase activity
GO:0046872 metal ion binding

Biological Process:
GO:0006139 nucleobase-containing compound metabolic process
GO:0090305 nucleic acid phosphodiester bond hydrolysis

Cellular Component:
GO:0005634 nucleus
GO:0005737 cytoplasm

-  Descriptions from all associated GenBank mRNAs
  HM005438 - Homo sapiens clone HTL-T-125 testicular tissue protein Li 125 mRNA, complete cds.
AK094438 - Homo sapiens cDNA FLJ37119 fis, clone BRACE2022333.
BC131749 - Homo sapiens exonuclease 3'-5' domain containing 3, mRNA (cDNA clone IMAGE:40118457), with apparent retained intron.
BC037355 - Homo sapiens exonuclease 3'-5' domain containing 3, mRNA (cDNA clone IMAGE:4622851), complete cds.
BC033079 - Homo sapiens exonuclease 3'-5' domain containing 3, mRNA (cDNA clone IMAGE:5455686), with apparent retained intron.
BC069205 - Homo sapiens exonuclease 3'-5' domain containing 3, mRNA (cDNA clone IMAGE:6574528), with apparent retained intron.
KJ902720 - Synthetic construct Homo sapiens clone ccsbBroadEn_12114 EXD3 gene, encodes complete protein.
CU691486 - Synthetic construct Homo sapiens gateway clone IMAGE:100021886 5' read FLJ20433 mRNA.
BC039252 - Homo sapiens exonuclease 3'-5' domain containing 3, mRNA (cDNA clone IMAGE:5298461), complete cds.
BC065002 - Homo sapiens exonuclease 3'-5' domain containing 3, mRNA (cDNA clone IMAGE:6023681), complete cds.
AK000440 - Homo sapiens cDNA FLJ20433 fis, clone KAT03767.
JD366578 - Sequence 347602 from Patent EP1572962.
JD185393 - Sequence 166417 from Patent EP1572962.
JD292584 - Sequence 273608 from Patent EP1572962.
JD546890 - Sequence 527914 from Patent EP1572962.
JD232413 - Sequence 213437 from Patent EP1572962.
JD149432 - Sequence 130456 from Patent EP1572962.
JD185391 - Sequence 166415 from Patent EP1572962.
JD283708 - Sequence 264732 from Patent EP1572962.
JD561715 - Sequence 542739 from Patent EP1572962.
JD235066 - Sequence 216090 from Patent EP1572962.
JD490060 - Sequence 471084 from Patent EP1572962.
JD344854 - Sequence 325878 from Patent EP1572962.
JD447396 - Sequence 428420 from Patent EP1572962.
JD139199 - Sequence 120223 from Patent EP1572962.
JD306539 - Sequence 287563 from Patent EP1572962.
JD529543 - Sequence 510567 from Patent EP1572962.
JD217500 - Sequence 198524 from Patent EP1572962.
JD452779 - Sequence 433803 from Patent EP1572962.
JD138802 - Sequence 119826 from Patent EP1572962.
JD246974 - Sequence 227998 from Patent EP1572962.
JD413418 - Sequence 394442 from Patent EP1572962.
JD198118 - Sequence 179142 from Patent EP1572962.
JD408034 - Sequence 389058 from Patent EP1572962.
JD144944 - Sequence 125968 from Patent EP1572962.
JD487079 - Sequence 468103 from Patent EP1572962.
KJ905487 - Synthetic construct Homo sapiens clone ccsbBroadEn_15085 EXD3 gene, encodes complete protein.
JD342608 - Sequence 323632 from Patent EP1572962.
JD341302 - Sequence 322326 from Patent EP1572962.
JD178751 - Sequence 159775 from Patent EP1572962.
JD134233 - Sequence 115257 from Patent EP1572962.

-  Other Names for This Gene
  Alternate Gene Symbols: B8A4U7, C9JIQ9, HBE269, MUT7_HUMAN, NR_104599, Q2TAK4, Q8N3X4, Q8N9H8, Q8NHD1, Q96NP1, uc064xlj.1
UCSC ID: uc064xlj.1
RefSeq Accession: NR_104599
Protein: Q8N9H8 (aka MUT7_HUMAN)

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.