Human Gene DDX42 (ENST00000457800.3) Description and Page Index
  Description: DEAD-box helicase 42 (from HGNC DDX42)
RefSeq Summary (NM_203499): This gene encodes a member of the Asp-Glu-Ala-Asp (DEAD) box protein family. Members of this protein family are putative RNA helicases, and are implicated in a number of cellular processes involving alteration of RNA secondary structure such as translation initiation, nuclear and mitochondrial splicing, and ribosome and spliceosome assembly. Members of this family are believed to be involved in embryogenesis, spermatogenesis, and cellular growth and division. Two transcript variants encoding the same protein have been identified for this gene. [provided by RefSeq, Jul 2008].
Gencode Transcript: ENST00000457800.3
Gencode Gene: ENSG00000198231.13
Transcript (Including UTRs)
   Position: hg38 chr17:63,792,531-63,819,246 Size: 26,716 Total Exon Count: 17 Strand: +
Coding Region
   Position: hg38 chr17:63,792,548-63,818,067 Size: 25,520 Coding Exon Count: 17 

Page IndexSequence and LinksCTDRNA-Seq ExpressionMicroarray ExpressionRNA Structure
Other SpeciesmRNA DescriptionsPathwaysOther NamesMethods
Data last updated: 2019-09-04

-  Sequence and Links to Tools and Databases
Genomic Sequence (chr17:63,792,531-63,819,246)mRNA (may differ from genome)Protein (708 aa)
Gene SorterGenome BrowserOther Species FASTAGene interactionsTable SchemaBioGPS
MGIPubMedStanford SOURCEUniProtKBWikipedia

-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene           more ... click here to view the complete list

-  RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
  Highest median expression: 42.00 RPKM in Ovary
Total median expression: 1544.79 RPKM

View in GTEx track of Genome Browser    View at GTEx portal     View GTEx Body Map

+  Microarray Expression Data
  Press "+" in the title bar above to open this section.

-  mRNA Secondary Structure of 3' and 5' UTRs
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -0.6017-0.035 Picture PostScript Text
3' UTR -362.801179-0.308 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
Genome BrowserGenome BrowserNo orthologNo orthologNo orthologNo ortholog
Gene Details     
Gene Sorter     
Protein SequenceProtein Sequence    

-  Descriptions from all associated GenBank mRNAs
  KF612910 - Homo sapiens MAP3K3/DDX42 fusion protein 1 mRNA, partial cds.
KF612911 - Homo sapiens MAP3K3/DDX42 fusion protein 2 mRNA, partial cds.
LF209396 - JP 2014500723-A/16899: Polycomb-Associated Non-Coding RNAs.
MA444973 - JP 2018138019-A/16899: Polycomb-Associated Non-Coding RNAs.
AK125169 - Homo sapiens cDNA FLJ43179 fis, clone FCBBF3013307, highly similar to Homo sapiens RNA helicase-related protein mRNA.
LP895346 - Sequence 210 from Patent EP3253886.
BC093081 - Homo sapiens DEAD (Asp-Glu-Ala-Asp) box polypeptide 42, mRNA (cDNA clone MGC:111493 IMAGE:30407786), complete cds.
AB384900 - Synthetic construct DNA, clone: pF1KB4115, Homo sapiens DDX42 gene for ATP-dependent RNA helicase DDX42, complete cds, without stop codon, in Flexi system.
AB036090 - Homo sapiens mRNA for RNA helicase-related protein, complete cds.
BC015505 - Homo sapiens DEAD (Asp-Glu-Ala-Asp) box polypeptide 42, mRNA (cDNA clone MGC:9119 IMAGE:3905607), complete cds.
BC078667 - Homo sapiens DEAD (Asp-Glu-Ala-Asp) box polypeptide 42, mRNA (cDNA clone IMAGE:6107393), partial cds.
AK292908 - Homo sapiens cDNA FLJ78746 complete cds, highly similar to Homo sapiens, RNA helicase-related protein.
AK095772 - Homo sapiens cDNA FLJ38453 fis, clone FEBRA2019663, highly similar to Homo sapiens DEAD (Asp-Glu-Ala-Asp) box polypeptide 42 (DDX42), transcript variant 2, mRNA.
AF083255 - Homo sapiens RNA helicase-related protein mRNA, complete cds.
CU677323 - Synthetic construct Homo sapiens gateway clone IMAGE:100017496 5' read DDX42 mRNA.
LF328272 - JP 2014500723-A/135775: Polycomb-Associated Non-Coding RNAs.
MA563849 - JP 2018138019-A/135775: Polycomb-Associated Non-Coding RNAs.
LF328276 - JP 2014500723-A/135779: Polycomb-Associated Non-Coding RNAs.
MA563853 - JP 2018138019-A/135779: Polycomb-Associated Non-Coding RNAs.
LF328277 - JP 2014500723-A/135780: Polycomb-Associated Non-Coding RNAs.
MA563854 - JP 2018138019-A/135780: Polycomb-Associated Non-Coding RNAs.
AK126480 - Homo sapiens cDNA FLJ44516 fis, clone UTERU3002600, highly similar to Homo sapiens DEAD (Asp-Glu-Ala-Asp) box polypeptide 42 (DDX42), transcript variant 2, mRNA.
LF328280 - JP 2014500723-A/135783: Polycomb-Associated Non-Coding RNAs.
MA563857 - JP 2018138019-A/135783: Polycomb-Associated Non-Coding RNAs.
AF147429 - Homo sapiens full length insert cDNA clone YP80G10.
LF328281 - JP 2014500723-A/135784: Polycomb-Associated Non-Coding RNAs.
MA563858 - JP 2018138019-A/135784: Polycomb-Associated Non-Coding RNAs.
AK122737 - Homo sapiens cDNA FLJ16253 fis, clone HLUNG2015184, highly similar to Homo sapiens DEAD (Asp-Glu-Ala-Asp) box polypeptide 42 (DDX42), transcript variant 2, mRNA.
AK001964 - Homo sapiens cDNA FLJ11102 fis, clone PLACE1005646, highly similar to Homo sapiens DEAD (Asp-Glu-Ala-Asp) box polypeptide 42 (DDX42), transcript variant 2, mRNA.
AL050096 - Homo sapiens mRNA; cDNA DKFZp586A0419 (from clone DKFZp586A0419).
LF328282 - JP 2014500723-A/135785: Polycomb-Associated Non-Coding RNAs.
MA563859 - JP 2018138019-A/135785: Polycomb-Associated Non-Coding RNAs.
AK096751 - Homo sapiens cDNA FLJ39432 fis, clone PROST2002927.
LF328283 - JP 2014500723-A/135786: Polycomb-Associated Non-Coding RNAs.
MA563860 - JP 2018138019-A/135786: Polycomb-Associated Non-Coding RNAs.
BC008208 - Homo sapiens DEAD (Asp-Glu-Ala-Asp) box polypeptide 42, mRNA (cDNA clone IMAGE:3869206), partial cds.
LF328284 - JP 2014500723-A/135787: Polycomb-Associated Non-Coding RNAs.
MA563861 - JP 2018138019-A/135787: Polycomb-Associated Non-Coding RNAs.
JD128643 - Sequence 109667 from Patent EP1572962.
JD068362 - Sequence 49386 from Patent EP1572962.
JD408731 - Sequence 389755 from Patent EP1572962.
LF328285 - JP 2014500723-A/135788: Polycomb-Associated Non-Coding RNAs.
MA563862 - JP 2018138019-A/135788: Polycomb-Associated Non-Coding RNAs.
JD442231 - Sequence 423255 from Patent EP1572962.
JD547096 - Sequence 528120 from Patent EP1572962.
LF328286 - JP 2014500723-A/135789: Polycomb-Associated Non-Coding RNAs.
MA563863 - JP 2018138019-A/135789: Polycomb-Associated Non-Coding RNAs.
JD286398 - Sequence 267422 from Patent EP1572962.
LF328287 - JP 2014500723-A/135790: Polycomb-Associated Non-Coding RNAs.
MA563864 - JP 2018138019-A/135790: Polycomb-Associated Non-Coding RNAs.
LF328288 - JP 2014500723-A/135791: Polycomb-Associated Non-Coding RNAs.
MA563865 - JP 2018138019-A/135791: Polycomb-Associated Non-Coding RNAs.
JD328908 - Sequence 309932 from Patent EP1572962.
LF328289 - JP 2014500723-A/135792: Polycomb-Associated Non-Coding RNAs.
MA563866 - JP 2018138019-A/135792: Polycomb-Associated Non-Coding RNAs.
JD439467 - Sequence 420491 from Patent EP1572962.
JD563679 - Sequence 544703 from Patent EP1572962.

-  Biochemical and Signaling Pathways
  KEGG - Kyoto Encyclopedia of Genes and Genomes
hsa03040 - Spliceosome

-  Other Names for This Gene
  Alternate Gene Symbols: A0A0A0MSJ0, AF083255, uc060iqm.1
UCSC ID: uc060iqm.1
RefSeq Accession: NM_203499

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.