Human Gene RUFY2 (ENST00000454950.6) Description and Page Index
Description: Homo sapiens RUN and FYVE domain containing 2 (RUFY2), transcript variant 3, mRNA. (from RefSeq NM_001278225)
Gencode Transcript: ENST00000454950.6
Gencode Gene: ENSG00000204130.13
Transcript (Including UTRs)
Position: hg38 chr10:68,377,194-68,407,294 Size: 30,101 Total Exon Count: 12 Strand: -
Position: hg38 chr10:68,378,562-68,407,189 Size: 28,628 Coding Exon Count: 12
Data last updated: 2019-09-04
Sequence and Links to Tools and Databases
Comments and Description Text from UniProtKB
DESCRIPTION: RecName: Full=RUN and FYVE domain-containing protein 2; AltName: Full=Rab4-interacting protein related;
SUBUNIT: Interacts with BMX. SUBCELLULAR LOCATION: Nucleus (By similarity). TISSUE SPECIFICITY: Expressed in brain, lung and testis. SIMILARITY: Contains 1 FYVE-type zinc finger. SIMILARITY: Contains 1 RUN domain. SEQUENCE CAUTION: Sequence=CAI17232.1; Type=Erroneous gene model prediction;
Comparative Toxicogenomics Database (CTD)
RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
Microarray Expression Data
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mRNA Secondary Structure of 3' and 5' UTRs
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
Protein Domain and Structure Information
InterPro Domains: Graphical view of domain structure IPR004012 - Run
IPR000306 - Znf_FYVE
IPR017455 - Znf_FYVE-rel
IPR011011 - Znf_FYVE_PHD
IPR013083 - Znf_RING/FYVE/PHD
Pfam Domains: PF01363 - FYVE zinc finger
PF02759 - RUN domain
ModBase Predicted Comparative 3D Structure on Q8WXA3
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
Gene Ontology (GO) Annotations with Structured Vocabulary
Descriptions from all associated GenBank mRNAs
AK000925 - Homo sapiens cDNA FLJ10063 fis, clone HEMBA1001446. AF461266 - Homo sapiens RUFY2 (RUFY2) mRNA, complete cds. AB040970 - Homo sapiens mRNA for KIAA1537 protein, partial cds. AK127019 - Homo sapiens cDNA FLJ45075 fis, clone BRAWH3027533, highly similar to RUN and FYVE domain-containing protein 2. AK094214 - Homo sapiens cDNA FLJ36895 fis, clone BRACE2000965, weakly similar to Early endosome antigen 1, 162kD. AF411980 - Homo sapiens Run- and FYVE-domain containing protein Rabip4R mRNA, complete cds. AB384229 - Synthetic construct DNA, clone: pF1KSDA1537, Homo sapiens RUFY2 gene for RUN and FYVE domain-containing protein 2, complete cds, without stop codon, in Flexi system. BC020659 - Homo sapiens cDNA clone IMAGE:4717881, containing frame-shift errors. BC041092 - Homo sapiens RUN and FYVE domain containing 2, mRNA (cDNA clone MGC:46077 IMAGE:5731891), complete cds. LF384642 - JP 2014500723-A/192145: Polycomb-Associated Non-Coding RNAs. MA620219 - JP 2018138019-A/192145: Polycomb-Associated Non-Coding RNAs. AK294211 - Homo sapiens cDNA FLJ58796 complete cds, highly similar to RUN and FYVE domain-containing protein 2. HQ448515 - Synthetic construct Homo sapiens clone IMAGE:100071949; CCSB011211_01 RUN and FYVE domain containing 2 (RUFY2) gene, encodes complete protein. KJ894233 - Synthetic construct Homo sapiens clone ccsbBroadEn_03627 RUFY2 gene, encodes complete protein. LF322662 - JP 2014500723-A/130165: Polycomb-Associated Non-Coding RNAs. MA558239 - JP 2018138019-A/130165: Polycomb-Associated Non-Coding RNAs. AY528716 - Homo sapiens antigen MU-RMS-40.17 (RUFY2) mRNA, partial cds. CU691950 - Synthetic construct Homo sapiens gateway clone IMAGE:100021176 5' read RUFY2 mRNA. BC062660 - Homo sapiens RUN and FYVE domain containing 2, mRNA (cDNA clone IMAGE:6716008). LF322660 - JP 2014500723-A/130163: Polycomb-Associated Non-Coding RNAs. MA558237 - JP 2018138019-A/130163: Polycomb-Associated Non-Coding RNAs. LF322659 - JP 2014500723-A/130162: Polycomb-Associated Non-Coding RNAs. MA558236 - JP 2018138019-A/130162: Polycomb-Associated Non-Coding RNAs. LF322657 - JP 2014500723-A/130160: Polycomb-Associated Non-Coding RNAs. MA558234 - JP 2018138019-A/130160: Polycomb-Associated Non-Coding RNAs. LF322656 - JP 2014500723-A/130159: Polycomb-Associated Non-Coding RNAs. MA558233 - JP 2018138019-A/130159: Polycomb-Associated Non-Coding RNAs.
Other Names for This Gene
Alternate Gene Symbols: B3KXB2, KIAA1537, NM_001278225, Q5TC48, Q8IW33, Q8WXA3, Q96P51, Q9P1Z1, RABIP4R, RUFY2_HUMAN, uc010qiw.1, uc010qiw.2, uc010qiw.3 UCSC ID: uc010qiw.3 RefSeq Accession: NM_001278225
(aka RUFY2_HUMAN) Q8WXA3
Methods, Credits, and Use Restrictions
for details on how this gene model was made and data restrictions if any.