Human Gene OSBPL9 (ENST00000453295.5) Description and Page Index
  Description: Homo sapiens oxysterol binding protein like 9 (OSBPL9), transcript variant 3, mRNA. (from RefSeq NM_148906)
RefSeq Summary (NM_148906): This gene encodes a member of the oxysterol-binding protein (OSBP) family, a group of intracellular lipid receptors. Most members contain an N-terminal pleckstrin homology domain and a highly conserved C-terminal OSBP-like sterol-binding domain, although some members contain only the sterol-binding domain. This family member functions as a cholesterol transfer protein that regulates Golgi structure and function. Multiple transcript variants, most of which encode distinct isoforms, have been identified. Related pseudogenes have been identified on chromosomes 3, 11 and 12. [provided by RefSeq, Jul 2010].
Gencode Transcript: ENST00000453295.5
Gencode Gene: ENSG00000117859.19
Transcript (Including UTRs)
   Position: hg38 chr1:51,617,109-51,788,469 Size: 171,361 Total Exon Count: 23 Strand: +
Coding Region
   Position: hg38 chr1:51,617,111-51,787,789 Size: 170,679 Coding Exon Count: 23 

Page IndexSequence and LinksUniProtKB CommentsCTDRNA-Seq ExpressionMicroarray Expression
RNA StructureProtein StructureOther SpeciesGO AnnotationsmRNA DescriptionsPathways
Other NamesMethods
Data last updated: 2019-09-04

-  Sequence and Links to Tools and Databases
 
Genomic Sequence (chr1:51,617,109-51,788,469)mRNA (may differ from genome)Protein (719 aa)
Gene SorterGenome BrowserOther Species FASTAGene interactionsTable SchemaBioGPS
CGAPEnsemblEntrez GeneExonPrimerGeneCardsHGNC
LynxMGIneXtProtOMIMPubMedReactome
Stanford SOURCEUniProtKBWikipedia

-  Comments and Description Text from UniProtKB
  ID: OSBL9_HUMAN
DESCRIPTION: RecName: Full=Oxysterol-binding protein-related protein 9; Short=ORP-9; Short=OSBP-related protein 9;
TISSUE SPECIFICITY: Widely expressed.
SIMILARITY: Belongs to the OSBP family.
SIMILARITY: Contains 1 PH domain.
SEQUENCE CAUTION: Sequence=CAH71119.1; Type=Erroneous initiation;

-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene           more ... click here to view the complete list

-  RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
  Highest median expression: 33.07 RPKM in Cells - EBV-transformed lymphocytes
Total median expression: 717.23 RPKM



View in GTEx track of Genome Browser    View at GTEx portal     View GTEx Body Map

+  Microarray Expression Data
  Press "+" in the title bar above to open this section.

-  mRNA Secondary Structure of 3' and 5' UTRs
 
RegionFold EnergyBasesEnergy/Base
Display As
3' UTR -134.60680-0.198 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  InterPro Domains: Graphical view of domain structure
IPR000648 - Oxysterol-bd
IPR018494 - Oxysterol-bd_CS
IPR011993 - PH_like_dom
IPR001849 - Pleckstrin_homology

Pfam Domains:
PF01237 - Oxysterol-binding protein
PF00169 - PH domain

ModBase Predicted Comparative 3D Structure on Q96SU4
FrontTopSide
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-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
Genome BrowserGenome BrowserNo orthologNo orthologGenome BrowserNo ortholog
Gene Details     
Gene Sorter     
MGIRGD  WormBase 
Protein SequenceProtein Sequence  Protein Sequence 
AlignmentAlignment  Alignment 

-  Gene Ontology (GO) Annotations with Structured Vocabulary
  Molecular Function:
GO:0008289 lipid binding
GO:0015248 sterol transporter activity

Biological Process:
GO:0006699 bile acid biosynthetic process
GO:0006869 lipid transport
GO:0015918 sterol transport

Cellular Component:
GO:0005768 endosome
GO:0005794 Golgi apparatus
GO:0005829 cytosol
GO:0016020 membrane
GO:0031902 late endosome membrane
GO:0043231 intracellular membrane-bounded organelle


-  Descriptions from all associated GenBank mRNAs
  AK128043 - Homo sapiens cDNA FLJ46163 fis, clone TESTI4002774, highly similar to Oxysterol-binding protein-related protein 9.
LF383889 - JP 2014500723-A/191392: Polycomb-Associated Non-Coding RNAs.
MA619466 - JP 2018138019-A/191392: Polycomb-Associated Non-Coding RNAs.
AK056617 - Homo sapiens cDNA FLJ32055 fis, clone NTONG2001612, highly similar to Oxysterol-binding protein-related protein 9.
AK091703 - Homo sapiens cDNA FLJ34384 fis, clone HCHON1000131, weakly similar to KES1 PROTEIN.
AK027535 - Homo sapiens cDNA FLJ14629 fis, clone NT2RP2000448, weakly similar to KES1 PROTEIN.
AF392445 - Homo sapiens oxysterol-binding protein-like protein OSBPL9 (OSBPL9) mRNA, complete cds.
AY178997 - Homo sapiens oxysterol-binding protein-like protein 9 mRNA, complete cds.
AK297656 - Homo sapiens cDNA FLJ55808 complete cds, highly similar to Oxysterol-binding protein-related protein 9.
AK315167 - Homo sapiens cDNA, FLJ96142.
AK027707 - Homo sapiens cDNA FLJ14801 fis, clone NT2RP4001389, weakly similar to KES1 PROTEIN.
BC025978 - Homo sapiens oxysterol binding protein-like 9, mRNA (cDNA clone MGC:15035 IMAGE:3621193), complete cds.
AK022554 - Homo sapiens cDNA FLJ12492 fis, clone NT2RM2001632, weakly similar to KES1 PROTEIN.
CR457288 - Homo sapiens full open reading frame cDNA clone RZPDo834E0321D for gene OSBPL9, oxysterol binding protein-like 9; complete cds, incl. stopcodon.
AK124037 - Homo sapiens cDNA FLJ42043 fis, clone SPLEN2040824, highly similar to Oxysterol-binding protein-related protein 9.
AB208851 - Homo sapiens mRNA for oxysterol-binding protein-like protein 9 isoform f variant protein.
JD250052 - Sequence 231076 from Patent EP1572962.
AK074392 - Homo sapiens cDNA FLJ23812 fis, clone HRC09941.
LF206549 - JP 2014500723-A/14052: Polycomb-Associated Non-Coding RNAs.
MA442126 - JP 2018138019-A/14052: Polycomb-Associated Non-Coding RNAs.
LF356119 - JP 2014500723-A/163622: Polycomb-Associated Non-Coding RNAs.
MA591696 - JP 2018138019-A/163622: Polycomb-Associated Non-Coding RNAs.
BC006160 - Homo sapiens oxysterol binding protein-like 9, mRNA (cDNA clone IMAGE:3638030), partial cds.
LF356118 - JP 2014500723-A/163621: Polycomb-Associated Non-Coding RNAs.
MA591695 - JP 2018138019-A/163621: Polycomb-Associated Non-Coding RNAs.
JD088944 - Sequence 69968 from Patent EP1572962.
JD206596 - Sequence 187620 from Patent EP1572962.
JD509287 - Sequence 490311 from Patent EP1572962.
JD429207 - Sequence 410231 from Patent EP1572962.

-  Biochemical and Signaling Pathways
  Reactome (by CSHL, EBI, and GO)

Protein Q96SU4 (Reactome details) participates in the following event(s):

R-HSA-8867667 OSBPs transport 25OH-CHOL from ER membrane to plasma membrane
R-HSA-192105 Synthesis of bile acids and bile salts
R-HSA-194068 Bile acid and bile salt metabolism
R-HSA-8957322 Metabolism of steroids
R-HSA-556833 Metabolism of lipids
R-HSA-1430728 Metabolism

-  Other Names for This Gene
  Alternate Gene Symbols: B1AKJ8, B3KPQ4, D3DQ31, NM_148906, ORP9, OSBL9_HUMAN, OSBP4, Q5TFC0, Q6IA67, Q86YQ3, Q8NB17, Q8TAS8, Q96SK4, Q96SU4, Q9H9X2, uc009vza.1, uc009vza.2, uc009vza.3, uc009vza.4
UCSC ID: uc009vza.4
RefSeq Accession: NM_148906
Protein: Q96SU4 (aka OSBL9_HUMAN)
CCDS: CCDS41332.3, CCDS41333.2, CCDS55598.1

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.