Human Gene MINDY2 (ENST00000450403.3) Description and Page Index
  Description: Homo sapiens MINDY lysine 48 deubiquitinase 2 (MINDY2), transcript variant 2, mRNA. (from RefSeq NM_001040453)
Gencode Transcript: ENST00000450403.3
Gencode Gene: ENSG00000128923.11
Transcript (Including UTRs)
   Position: hg38 chr15:58,771,362-58,857,533 Size: 86,172 Total Exon Count: 9 Strand: +
Coding Region
   Position: hg38 chr15:58,771,396-58,854,610 Size: 83,215 Coding Exon Count: 9 

Page IndexSequence and LinksUniProtKB CommentsRNA-Seq ExpressionMicroarray ExpressionRNA Structure
Protein StructureOther SpeciesGO AnnotationsmRNA DescriptionsOther NamesMethods
Data last updated: 2019-09-04

-  Sequence and Links to Tools and Databases
 
Genomic Sequence (chr15:58,771,362-58,857,533)mRNA (may differ from genome)Protein (620 aa)
Gene SorterGenome BrowserOther Species FASTATable SchemaBioGPSEnsembl
Entrez GeneExonPrimerGeneCardsHPRDLynxMGI
neXtProtOMIMPubMedStanford SOURCEUniProtKB

-  Comments and Description Text from UniProtKB
  ID: FA63B_HUMAN
DESCRIPTION: RecName: Full=Protein FAM63B;
SIMILARITY: Belongs to the FAM63 family.
SEQUENCE CAUTION: Sequence=EAW77545.1; Type=Erroneous gene model prediction;

-  RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
  Highest median expression: 15.67 RPKM in Brain - Cerebellar Hemisphere
Total median expression: 241.13 RPKM



View in GTEx track of Genome Browser    View at GTEx portal     View GTEx Body Map

+  Microarray Expression Data
  Press "+" in the title bar above to open this section.

-  mRNA Secondary Structure of 3' and 5' UTRs
 
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -12.6034-0.371 Picture PostScript Text
3' UTR -734.302923-0.251 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  InterPro Domains: Graphical view of domain structure
IPR007518 - DUF544

Pfam Domains:
PF04424 - MINDY deubiquitinase

ModBase Predicted Comparative 3D Structure on Q8NBR6
FrontTopSide
The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
Genome BrowserGenome BrowserNo orthologNo orthologNo orthologGenome Browser
Gene Details    Gene Details
Gene Sorter    Gene Sorter
MGIRGDEnsembl  SGD
Protein SequenceProtein Sequence   Protein Sequence
AlignmentAlignment   Alignment

-  Gene Ontology (GO) Annotations with Structured Vocabulary
  Molecular Function:
GO:0004843 thiol-dependent ubiquitin-specific protease activity
GO:0008233 peptidase activity
GO:0008234 cysteine-type peptidase activity
GO:0016787 hydrolase activity
GO:0016807 cysteine-type carboxypeptidase activity
GO:0036435 K48-linked polyubiquitin binding
GO:0036459 thiol-dependent ubiquitinyl hydrolase activity
GO:0070530 K63-linked polyubiquitin binding
GO:0071795 K11-linked polyubiquitin binding
GO:0071796 K6-linked polyubiquitin binding
GO:1990380 Lys48-specific deubiquitinase activity

Biological Process:
GO:0006508 proteolysis
GO:0008150 biological_process
GO:0071108 protein K48-linked deubiquitination

Cellular Component:
GO:0005654 nucleoplasm


-  Descriptions from all associated GenBank mRNAs
  AL833610 - Homo sapiens mRNA; cDNA DKFZp686O1367 (from clone DKFZp686O1367).
BC060514 - Homo sapiens cDNA clone IMAGE:6107637, containing frame-shift errors.
AK297291 - Homo sapiens cDNA FLJ52099 complete cds.
AK075319 - Homo sapiens cDNA FLJ90838 fis, clone Y79AA1002129.
BC140811 - Homo sapiens family with sequence similarity 63, member B, mRNA (cDNA clone MGC:176488 IMAGE:9021679), complete cds.
BC144616 - Homo sapiens family with sequence similarity 63, member B, mRNA (cDNA clone MGC:178164 IMAGE:9053147), complete cds.
AB032990 - Homo sapiens mRNA for KIAA1164 protein, partial cds.
AB075509 - Homo sapiens neuroblastoma cDNA, clone:Nbla00402, full insert sequence.
JD276388 - Sequence 257412 from Patent EP1572962.
KJ902674 - Synthetic construct Homo sapiens clone ccsbBroadEn_12068 FAM63B gene, encodes complete protein.
JD538335 - Sequence 519359 from Patent EP1572962.
JD327891 - Sequence 308915 from Patent EP1572962.
JD301333 - Sequence 282357 from Patent EP1572962.
JD510687 - Sequence 491711 from Patent EP1572962.
AK022891 - Homo sapiens cDNA FLJ12829 fis, clone NT2RP2003034.
JD447742 - Sequence 428766 from Patent EP1572962.
JD281079 - Sequence 262103 from Patent EP1572962.
JD304669 - Sequence 285693 from Patent EP1572962.
JD402909 - Sequence 383933 from Patent EP1572962.
JD212677 - Sequence 193701 from Patent EP1572962.
JD198056 - Sequence 179080 from Patent EP1572962.
JD173985 - Sequence 155009 from Patent EP1572962.
JD324245 - Sequence 305269 from Patent EP1572962.
JD413346 - Sequence 394370 from Patent EP1572962.
JD246857 - Sequence 227881 from Patent EP1572962.
JD537264 - Sequence 518288 from Patent EP1572962.
JD381229 - Sequence 362253 from Patent EP1572962.
JD211150 - Sequence 192174 from Patent EP1572962.
JD462369 - Sequence 443393 from Patent EP1572962.
AL049226 - Homo sapiens mRNA; cDNA DKFZp564M0916 (from clone DKFZp564M0916).
JD092526 - Sequence 73550 from Patent EP1572962.
JD430275 - Sequence 411299 from Patent EP1572962.
JD529344 - Sequence 510368 from Patent EP1572962.
JD169556 - Sequence 150580 from Patent EP1572962.
JD169557 - Sequence 150581 from Patent EP1572962.
JD041676 - Sequence 22700 from Patent EP1572962.
JD055106 - Sequence 36130 from Patent EP1572962.
JD138272 - Sequence 119296 from Patent EP1572962.
JD175862 - Sequence 156886 from Patent EP1572962.
JD096421 - Sequence 77445 from Patent EP1572962.
JD308893 - Sequence 289917 from Patent EP1572962.
JD332277 - Sequence 313301 from Patent EP1572962.
JD332278 - Sequence 313302 from Patent EP1572962.
JD448255 - Sequence 429279 from Patent EP1572962.
JD192735 - Sequence 173759 from Patent EP1572962.
JD392959 - Sequence 373983 from Patent EP1572962.
JD517944 - Sequence 498968 from Patent EP1572962.
JD517945 - Sequence 498969 from Patent EP1572962.
JD219994 - Sequence 201018 from Patent EP1572962.
JD509997 - Sequence 491021 from Patent EP1572962.
BC035563 - Homo sapiens family with sequence similarity 63, member B, mRNA (cDNA clone IMAGE:4517892), with apparent retained intron.
JD047306 - Sequence 28330 from Patent EP1572962.
DL491751 - Novel nucleic acids.
DL490331 - Novel nucleic acids.
JD354910 - Sequence 335934 from Patent EP1572962.
JD359154 - Sequence 340178 from Patent EP1572962.
JD549719 - Sequence 530743 from Patent EP1572962.
JD315948 - Sequence 296972 from Patent EP1572962.
JD324262 - Sequence 305286 from Patent EP1572962.
JD101394 - Sequence 82418 from Patent EP1572962.
JD064347 - Sequence 45371 from Patent EP1572962.
JD430634 - Sequence 411658 from Patent EP1572962.
JD172396 - Sequence 153420 from Patent EP1572962.
JD127930 - Sequence 108954 from Patent EP1572962.
JD453641 - Sequence 434665 from Patent EP1572962.
JD545024 - Sequence 526048 from Patent EP1572962.
JD548130 - Sequence 529154 from Patent EP1572962.
JD258464 - Sequence 239488 from Patent EP1572962.
JD411983 - Sequence 393007 from Patent EP1572962.
JD083391 - Sequence 64415 from Patent EP1572962.
JD483023 - Sequence 464047 from Patent EP1572962.
JD473880 - Sequence 454904 from Patent EP1572962.
JD452149 - Sequence 433173 from Patent EP1572962.
JD099966 - Sequence 80990 from Patent EP1572962.
JD351825 - Sequence 332849 from Patent EP1572962.
JD523749 - Sequence 504773 from Patent EP1572962.
JD201278 - Sequence 182302 from Patent EP1572962.
JD430175 - Sequence 411199 from Patent EP1572962.
JD557351 - Sequence 538375 from Patent EP1572962.
JD529180 - Sequence 510204 from Patent EP1572962.
JD169287 - Sequence 150311 from Patent EP1572962.
JD169288 - Sequence 150312 from Patent EP1572962.
JD041305 - Sequence 22329 from Patent EP1572962.
JD321061 - Sequence 302085 from Patent EP1572962.
JD388208 - Sequence 369232 from Patent EP1572962.
JD118351 - Sequence 99375 from Patent EP1572962.
JD229231 - Sequence 210255 from Patent EP1572962.
JD268440 - Sequence 249464 from Patent EP1572962.
JD531386 - Sequence 512410 from Patent EP1572962.
JD175511 - Sequence 156535 from Patent EP1572962.
JD331582 - Sequence 312606 from Patent EP1572962.
JD182091 - Sequence 163115 from Patent EP1572962.
JD349022 - Sequence 330046 from Patent EP1572962.
JD507968 - Sequence 488992 from Patent EP1572962.
JD067641 - Sequence 48665 from Patent EP1572962.
JD364656 - Sequence 345680 from Patent EP1572962.
JD364657 - Sequence 345681 from Patent EP1572962.
JD377817 - Sequence 358841 from Patent EP1572962.

-  Other Names for This Gene
  Alternate Gene Symbols: B2RTT8, FA63B_HUMAN, FAM63B, KIAA1164, NM_001040453, Q8NBR6, Q9ULQ6, uc002afi.1, uc002afi.2, uc002afi.3, uc002afi.4
UCSC ID: uc002afi.4
RefSeq Accession: NM_001040453
Protein: Q8NBR6 (aka FA63B_HUMAN)
CCDS: CCDS42046.1, CCDS45268.1

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.